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本帖最后由 细胞海洋 于 2010-6-19 13:37 编辑 - j6 n% p+ m0 d) F
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FOREWORD, n# j$ z9 e, u. o, Z
Stem cell biology is emerging as a field in biology with tremendous therapeutic potential.- |. \$ v. k& T0 v- V
Making this potential a reality requires an international effort. The recognition
; R$ ^4 Y, R) [8 h3 n4 pthat such a promising yet multifaceted discipline needs fostering led to the establishment; r, k" T$ I! D: Q5 M) h9 G9 r# N
of the International Society for Stem Cell Research (ISSCR). Central to the efforts of the
& q& W: E$ A G$ z% _) |, _; kISSCR is the development of tools to ensure the success of stem cell researchers. What, z3 ~$ v- G) u5 u2 h# s- l
better way to do this than to collaborate with Current Protocols to develop this valuable: Y# e2 r8 D, k! o; [
compendium of protocols in stem cell biology?
|. {7 ^, P+ m$ QStem cell researchers have developed a number of breakthrough techniques, from the
- [. G* d# K3 x( U c+ Mderivation and manipulation of pluripotent embryonic stem cells to purification and
- ]6 N2 d" F X" b7 Q% B# L) [transplantation of tissue-restricted stem cells from adult organs. A number of laboratories
" |: U/ N7 T6 p+ Xhave become leaders in the field as a result of developing such techniques. The more/ t# l% Q2 P$ @8 g% Y$ C D% m& R4 }' Q
efficient scientists are at implementing new and powerful methodologies in their own5 F2 z# q4 p' }2 U9 ]1 \
laboratories, the faster stem cell biology will advance our understanding of normal
# e# ?* G( u/ y8 i/ udevelopment and lead to the development of therapies. Thus, the availability of quality$ n5 |% B+ r' t
protocols will have amajor impact on the success of the entire field. Current Protocols has1 X; D) o! H \) X: T: d ?
long been the premier volume for proven in-depth protocols regarding many aspects of& ^6 A; ~% o* q
biology, and this volume on stem cell biology will prove a valuable addition to researchers" _5 @ `, c8 I5 D; B X- X7 m
worldwide.
3 {2 I9 j' y9 B; R! lExperiments in stem cell biology must be interpreted with great caution as well as
+ A; l0 u- x" R- N; {; K) s( Lopenness to alternative explanations. For example, the recently discovered phenomenon! S& }0 h7 |, K$ W2 r" j
of cell fusion in vivo or the existence of tissue-restricted blood stem cells in peripheral
, ?" z$ J% K2 M- Itissues were initially misinterpreted as evidence for stem cell trans-differentiation.$ y/ u' y3 I2 T
It is very important that this compendium of protocols highlight potential pitfalls as well7 e5 l+ J& t' ^6 o' g E
as maintain the opportunity for clarification and correction when the need arises. The
8 z7 K6 n( G7 }$ C( h) Tfact that these protocols will be provided online will help ensure that researchers always
" R% z4 z+ W9 x! p: Ehave the latest, most up-to-date protocols available to them.
5 \6 {! [# G& G& X" {The stem cell field is burgeoning, and, as I have seen within the ISSCR, there is a genuine
- U0 p8 `6 d1 v c% n+ J9 o3 Dpush to share information and interact so that the field can move forward quickly. There
8 }1 E/ V7 v8 |7 F: y5 yis a drive to develop not only excellent basic research skills but to bring the findings0 M, C. i# X0 y( \' F
to clinical use so that patients can benefit. As a Hematology Attending Physician at
$ A% Y3 m. T3 z3 B7 `Children’s HospitalBoston, I treat children who have pediatric blood diseases or leukemia
+ H" L: c2 F' x5 e8 qand am drawn by the need to translate our research findings into therapies to help treat a
7 j8 ?% }. x/ }% Rnumber of diseases. The promise is great, but we need to deliver, and I believe Current' h( ]8 ]% g, p# o1 e( ]
Protocols in Stem Cell Biology will help tremendously.
2 P7 l, y' Q5 B$ d2 qLeonard I. Zon
# d% d) t# J6 n. _6 NCurrent Protocols in Stem Cell Biology% c# p8 @7 ~ ^9 m; K* x0 n
Published online June 2007 in Wiley Interscience (www.interscience.wiley.com).- ^! S1 v+ [: t! ^
DOI: 10.1002/9780470151808.scfores1+ O! _: _9 F/ l$ F. S; H
Copyright C 2007 John
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$ v7 h, I. f7 Z' z: P2 R附件为pdf全文,感谢原创提供者 ,大家回复之后就可以下载了
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