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本帖最后由 细胞海洋 于 2010-6-19 13:37 编辑
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% T' O" P! X6 l: A9 X4 c; }5 e+ nFOREWORD
1 G" h, n6 {" {, |Stem cell biology is emerging as a field in biology with tremendous therapeutic potential.
. s! N, o7 b$ G! gMaking this potential a reality requires an international effort. The recognition6 r6 ?! C! G" |3 n$ R8 x( D
that such a promising yet multifaceted discipline needs fostering led to the establishment" o: Z9 Z3 D6 ^1 x! k
of the International Society for Stem Cell Research (ISSCR). Central to the efforts of the
, y6 L& C1 }. n& l$ M7 sISSCR is the development of tools to ensure the success of stem cell researchers. What
4 @3 F4 c& |- `- c% t! d5 g* jbetter way to do this than to collaborate with Current Protocols to develop this valuable& v- ? V- d" v/ [2 c
compendium of protocols in stem cell biology?. P; j6 i% e: {. w
Stem cell researchers have developed a number of breakthrough techniques, from the5 E: k5 X! A- V/ \9 B
derivation and manipulation of pluripotent embryonic stem cells to purification and- S) `$ `6 g, H: s
transplantation of tissue-restricted stem cells from adult organs. A number of laboratories4 v7 B, J3 X' ?5 }9 S
have become leaders in the field as a result of developing such techniques. The more
! T8 m) Z, b+ y Sefficient scientists are at implementing new and powerful methodologies in their own( b' O' R* F! e
laboratories, the faster stem cell biology will advance our understanding of normal# L' k4 m3 M% u9 G( c
development and lead to the development of therapies. Thus, the availability of quality
. u4 ]1 f* Q4 ?- g' R4 k( d" tprotocols will have amajor impact on the success of the entire field. Current Protocols has# A, L, [9 W6 ^) u6 L8 ~# Z
long been the premier volume for proven in-depth protocols regarding many aspects of
- J# w! {: @$ t3 X0 I) u3 n) @# Rbiology, and this volume on stem cell biology will prove a valuable addition to researchers
/ K0 Q4 ?/ `, X$ i% yworldwide.9 ?+ _3 l2 x" X. o, d& V! {
Experiments in stem cell biology must be interpreted with great caution as well as
Z' O2 N, M. B. e) Yopenness to alternative explanations. For example, the recently discovered phenomenon
$ h& g u) M( D* h5 }of cell fusion in vivo or the existence of tissue-restricted blood stem cells in peripheral
' j6 g5 _0 g% {, t1 m: H6 }% w, |# itissues were initially misinterpreted as evidence for stem cell trans-differentiation.
: a2 I* D5 W, aIt is very important that this compendium of protocols highlight potential pitfalls as well
/ {) l" W- C1 ?) X* a2 k: Aas maintain the opportunity for clarification and correction when the need arises. The
5 I7 ] b& w( P1 W. ~fact that these protocols will be provided online will help ensure that researchers always
% h: n; b6 N; H5 {: @0 J8 ~# ahave the latest, most up-to-date protocols available to them.
% J( p6 I7 T/ j+ G6 G+ G3 ^+ _% z7 x' K! OThe stem cell field is burgeoning, and, as I have seen within the ISSCR, there is a genuine
- `" v, X# E H) p0 y+ Xpush to share information and interact so that the field can move forward quickly. There" L4 B* `# M1 l
is a drive to develop not only excellent basic research skills but to bring the findings
3 G$ T# o, o/ L2 a3 l: wto clinical use so that patients can benefit. As a Hematology Attending Physician at
1 A L F7 o& R6 ]6 ~& ?3 {: w3 _Children’s HospitalBoston, I treat children who have pediatric blood diseases or leukemia
8 {* P& [6 @" c: @* [ F9 rand am drawn by the need to translate our research findings into therapies to help treat a
' O4 a6 T7 u Q2 v, E# Nnumber of diseases. The promise is great, but we need to deliver, and I believe Current
" c7 i, C8 C& v4 C6 r DProtocols in Stem Cell Biology will help tremendously.
* S& b' w6 \* D! ]Leonard I. Zon! B( V. {0 T! ^$ Q5 ~% d
Current Protocols in Stem Cell Biology- r, M9 G; N7 ?& ~8 y& u4 F5 p( e
Published online June 2007 in Wiley Interscience (www.interscience.wiley.com).
& | k2 Y8 M; S7 b& s8 A/ i3 ~DOI: 10.1002/9780470151808.scfores1) s# @9 }# m* G' b; Y# v
Copyright C 2007 John
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