PDF电子书：Current_Protocols_in_Stem_Cell_Biology

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FOREWORD
2 v9 z: G% t3 [0 l/ a. YStem cell biology is emerging as a field in biology with tremendous therapeutic potential.
6 v( q9 Y6 ]" ?. n) E' DMaking this potential a reality requires an international effort. The recognition2 [9 E* e/ t5 p5 f; ~9 c
that such a promising yet multifaceted discipline needs fostering led to the establishment
5 c9 S( l" q* X* E# i# ?. S' e9 dof the International Society for Stem Cell Research (ISSCR). Central to the efforts of the
( A) F. w$ O8 ~( s/ lISSCR is the development of tools to ensure the success of stem cell researchers. What7 @/ J# \. }& c* k" s
better way to do this than to collaborate with Current Protocols to develop this valuable
  d  y2 j1 ?4 ^compendium of protocols in stem cell biology?
7 P0 ~8 h7 w8 r5 l: VStem cell researchers have developed a number of breakthrough techniques, from the% w: {% i* ~2 D7 T
derivation and manipulation of pluripotent embryonic stem cells to purification and5 a. V+ \/ |4 a8 |
transplantation of tissue-restricted stem cells from adult organs. A number of laboratories& p/ t# ?" P& m# E
have become leaders in the field as a result of developing such techniques. The more0 w' v+ [3 ?+ ?% i" B2 c! p
efficient scientists are at implementing new and powerful methodologies in their own
7 ~2 B7 ^- m- e' Zlaboratories, the faster stem cell biology will advance our understanding of normal% S( B/ {+ u9 p; f
development and lead to the development of therapies. Thus, the availability of quality
! Z( ]8 @3 j8 L6 v3 K+ Bprotocols will have amajor impact on the success of the entire field. Current Protocols has0 c9 Y% [; Z* F8 @  C) h, `
long been the premier volume for proven in-depth protocols regarding many aspects of
6 d- p; G  i- t' v" Obiology, and this volume on stem cell biology will prove a valuable addition to researchers* _7 F" S/ n0 C4 I$ t* s( `5 T. E! n* b
worldwide.
6 ?- w& |( b7 n0 f* {Experiments in stem cell biology must be interpreted with great caution as well as0 t  d0 ~( A3 G2 Z% J! w
openness to alternative explanations. For example, the recently discovered phenomenon
% _0 N9 P, l! O7 Q9 t1 mof cell fusion in vivo or the existence of tissue-restricted blood stem cells in peripheral
& }& h- u9 t7 n1 p, Ztissues were initially misinterpreted as evidence for stem cell trans-differentiation.. j( `# H. g: N# F* v; A' ~4 n  N
It is very important that this compendium of protocols highlight potential pitfalls as well
, k4 W: ~% L- ?% X" Kas maintain the opportunity for clarification and correction when the need arises. The
1 u, x% k9 P/ |# Sfact that these protocols will be provided online will help ensure that researchers always
! [0 Y8 X% A1 ~1 z$ K) n# [8 Lhave the latest, most up-to-date protocols available to them.
; r3 O8 Y" A/ ?! M7 L2 s* ]The stem cell field is burgeoning, and, as I have seen within the ISSCR, there is a genuine
5 w2 j3 \# z1 x( |& o  `push to share information and interact so that the field can move forward quickly. There/ o* i5 c+ t. h  {" a
is a drive to develop not only excellent basic research skills but to bring the findings5 N4 U2 r, ?+ @. g2 w7 \) X1 c
to clinical use so that patients can benefit. As a Hematology Attending Physician at
* M: G! w+ h! m4 LChildren’s HospitalBoston, I treat children who have pediatric blood diseases or leukemia, f! ?) H4 r0 @/ t" v) o# f
and am drawn by the need to translate our research findings into therapies to help treat a
8 R; Y% h' |8 o% s1 I8 n$ `, Dnumber of diseases. The promise is great, but we need to deliver, and I believe Current. ^7 y- ?4 V3 \8 Q
Protocols in Stem Cell Biology will help tremendously.' b3 x! ^; q/ @) d/ S2 K8 a; G0 B
Leonard I. Zon
) y/ W! L) c6 B: ^* r+ NCurrent Protocols in Stem Cell Biology- I4 T" m8 @; @: x* d; H# n7 J
Published online June 2007 in Wiley Interscience (www.interscience.wiley.com).
+ h4 t* [' }  U* _DOI: 10.1002/9780470151808.scfores17 d6 r) [% k+ o0 c# k, S
Copyright C
2007 John
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