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本帖最后由 细胞海洋 于 2010-6-19 13:37 编辑
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FOREWORD
+ R( y5 b/ u2 C. o- q8 @8 TStem cell biology is emerging as a field in biology with tremendous therapeutic potential.* G9 @/ ~' e: Z8 \& b/ G
Making this potential a reality requires an international effort. The recognition5 O4 }/ o! P, C- V, x1 |
that such a promising yet multifaceted discipline needs fostering led to the establishment( o2 `0 L3 \6 H
of the International Society for Stem Cell Research (ISSCR). Central to the efforts of the
& }6 z8 ~" x$ N4 VISSCR is the development of tools to ensure the success of stem cell researchers. What0 {; P- X8 I9 x2 Y4 S( \* [
better way to do this than to collaborate with Current Protocols to develop this valuable
4 K& Z9 b+ x0 p7 Ycompendium of protocols in stem cell biology?$ M; X- g( E8 X. d7 O
Stem cell researchers have developed a number of breakthrough techniques, from the8 |! H# b1 R/ A& y) l. t5 Y
derivation and manipulation of pluripotent embryonic stem cells to purification and. V" m4 g6 y, Y2 G* N) B
transplantation of tissue-restricted stem cells from adult organs. A number of laboratories
# O$ ~+ N; v/ S2 M; s9 A! \8 Chave become leaders in the field as a result of developing such techniques. The more/ r1 O8 N4 L" @
efficient scientists are at implementing new and powerful methodologies in their own& }6 X7 ]- G# X& S6 R
laboratories, the faster stem cell biology will advance our understanding of normal% V9 J* k) k4 `. \9 k6 z" e
development and lead to the development of therapies. Thus, the availability of quality6 Q( Q$ }& x- I/ [
protocols will have amajor impact on the success of the entire field. Current Protocols has6 c0 O, G# X) L
long been the premier volume for proven in-depth protocols regarding many aspects of5 h+ q S. [ V X9 k
biology, and this volume on stem cell biology will prove a valuable addition to researchers4 x M/ z# E) v! O% G
worldwide.
# B4 b& o# k: L3 o. l9 m* v/ sExperiments in stem cell biology must be interpreted with great caution as well as
7 o2 k7 M6 \4 m5 X4 t# i! ~openness to alternative explanations. For example, the recently discovered phenomenon/ Y) t! |6 ~# e; M. C8 e5 i
of cell fusion in vivo or the existence of tissue-restricted blood stem cells in peripheral1 T. D2 H; j, M4 ?1 D7 D$ N9 E% l
tissues were initially misinterpreted as evidence for stem cell trans-differentiation.
7 {4 D6 @& ~& h; D' t: g: }It is very important that this compendium of protocols highlight potential pitfalls as well2 q5 [1 F ]2 I5 k3 ]
as maintain the opportunity for clarification and correction when the need arises. The# a* [; s" E# Y: C! _& m
fact that these protocols will be provided online will help ensure that researchers always
0 l- O& M, {" k# ?7 ^* Qhave the latest, most up-to-date protocols available to them.
# B$ S8 ]5 N( P8 z9 |- ~* WThe stem cell field is burgeoning, and, as I have seen within the ISSCR, there is a genuine# A) V( |/ e5 D6 V
push to share information and interact so that the field can move forward quickly. There
) W" \% h) S4 s* ~1 {is a drive to develop not only excellent basic research skills but to bring the findings
5 ]- x# f) q" r+ d3 i+ Bto clinical use so that patients can benefit. As a Hematology Attending Physician at# C) z: w8 k9 V7 P4 R2 t: r
Children’s HospitalBoston, I treat children who have pediatric blood diseases or leukemia/ F. u7 O6 B9 V* p. z
and am drawn by the need to translate our research findings into therapies to help treat a
# P1 F$ t9 r! W7 G! M# i% P, Qnumber of diseases. The promise is great, but we need to deliver, and I believe Current! o& d& r4 d2 v. P
Protocols in Stem Cell Biology will help tremendously.
, P. H0 k# d+ sLeonard I. Zon: ?( f. D( _3 w8 C
Current Protocols in Stem Cell Biology
( j! S- p4 ~9 t0 E2 i6 rPublished online June 2007 in Wiley Interscience (www.interscience.wiley.com).9 Z- ~+ D0 F! l0 G
DOI: 10.1002/9780470151808.scfores1/ W6 m- x' r" L5 l# `
Copyright C 2007 John8 E) }7 r+ J& o* `: S
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发表于 2009-3-1 21:59
