EMT是幻象？？？

mckf111

The Fallacy of Epithelial Mesenchymal Transition in Neoplasia
, g, L- a4 e1 N. b- [David Tarin
8 w( d& H9 o: n+ }0 RRebecca and John Moores Cancer Center and Department of Pathology, University of California, San Diego, San Diego, California2 p7 p7 [( m' h- v# q, l4 p8 Y
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Abstract
6 z+ ^: P: V4 j% p( bEpithelial mesenchymal transition has been postulated as a versatile mechanism which facilitates cellular repositioning and redeployment during embryonic development, tissue reconstruction after injury, carcinogenesis, and tumor metas- tasis. The hypothesis originates from parallels drawn between the morphology and behavior of locomotory and sedentary cells in vitro and in various normal and pathologic processes in vivo. This review analyzes data from several studies on embryonic development, wound healing, and the pathology of human tumors, including work from our own laboratory, to assess the validity of the proposal. It is concluded that there is no convincing evidence for conversion of epithelial cells into mesenchymal cell lineages in vivo and that the biological repertoire of normal and malignant cells is sufficient to account for the events and processes observed, without needing to invoke radical changes in cell identity. (Cancer Res 2005; 65(14): 5996-6001)
- `3 L" r. I) @难怪EMT在肿瘤中作用的原始文献这么难找 原来是想象出来的  [& o$ G' C4 }6 g+ z

mckf111

回复 2# marrowstem
7 L3 L# u4 g/ ^0 W貌似不是他第一个提出来的 96年的那篇文章应该是第一次~~~
& s2 J0 p3 `/ ]; S8 p6 EBirchmeier CBW. Brand-Saberi B Epithelial-mesenchymal transitions in cancer progression. Acta Anat (Basel) 1996;156:217–26.

mckf111

回复 8# daviddow
" D7 J, f: A5 j5 T您用这话安慰自己吧 别蛊惑他人