EMT是幻象？？？

mckf111

The Fallacy of Epithelial Mesenchymal Transition in Neoplasia$ P6 z( C, N: f" X
David Tarin
" G" G; n$ B: P' H- k  JRebecca and John Moores Cancer Center and Department of Pathology, University of California, San Diego, San Diego, California  @0 t* w: W1 C7 X' |3 G8 p

4 j4 |9 z6 {  N  b6 CAbstract$ T2 q- I+ b! H# f3 l1 E
Epithelial mesenchymal transition has been postulated as a versatile mechanism which facilitates cellular repositioning and redeployment during embryonic development, tissue reconstruction after injury, carcinogenesis, and tumor metas- tasis. The hypothesis originates from parallels drawn between the morphology and behavior of locomotory and sedentary cells in vitro and in various normal and pathologic processes in vivo. This review analyzes data from several studies on embryonic development, wound healing, and the pathology of human tumors, including work from our own laboratory, to assess the validity of the proposal. It is concluded that there is no convincing evidence for conversion of epithelial cells into mesenchymal cell lineages in vivo and that the biological repertoire of normal and malignant cells is sufficient to account for the events and processes observed, without needing to invoke radical changes in cell identity. (Cancer Res 2005; 65(14): 5996-6001)7 ?. w; ~7 c5 U8 B' n# u7 a) x
难怪EMT在肿瘤中作用的原始文献这么难找 原来是想象出来的
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marrowstem

个人表示同意。在美国，病理医生一直对EMT嗤之以鼻，认为是一种假象。
' v& D$ I& k# J. G: oEMT有可能是Robert Weinberg杜撰出来的baby，开个玩笑。

flydayzhu

对研究就是要抱着一种怀疑的态度~

lixiaodong

学习。

mckf111

回复 2# marrowstem
0 B( c3 c" A( ~貌似不是他第一个提出来的 96年的那篇文章应该是第一次~~~
5 d" J6 u4 L) x! _* {( gBirchmeier CBW. Brand-Saberi B Epithelial-mesenchymal transitions in cancer progression. Acta Anat (Basel) 1996;156:217–26.

上海过客

EMT 是 杜撰 的 ，那么 MET  也就没有了 ？

wzx6660

just study

daviddow

任何新生的事物开始的时候都被认为是洪水猛兽，怪诞奇谈。哥白尼的日心说，达尔文的进化理论，都遇到这样的事情。EMT在验证的过程遭遇一些挫折也是正常的。大家还是抱着接受的态度多看些论文，多学些发育的知识，相信对这一个问题有更深的认识。不要开始就抱着不信任的度，科学只相信确凿重复的证据。

mckf111

回复 8# daviddow
( O2 J7 A& _- x7 B% }您用这话安慰自己吧 别蛊惑他人

daviddow

回复 9# mckf111
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    我没有蛊惑别人，也不用安慰自己。我想做研究的除了实验证据外不该相信别的。EMT是否是幻象也不会因为我们2个讨论一下就解决的，也不会因为1篇文献就解决的。