The transcriptional foundation of pluripotency

argonaute

A fundamental goal in biology is to understand the molecular
7 M7 R: ^2 W4 j2 U9 E. j- r: Qbasis of cell identity. Pluripotent embryonic stem (ES) cell
( i% h: w# c' r( Y- ~identity is governed by a set of transcription factors centred on
' C! z; [, j& t9 k+ I3 p4 i1 mthe triumvirate of Oct4, Sox2 and Nanog. These proteins often
4 Y  ?$ g( w- r* m0 X8 Rbind to closely localised genomic sites. Recent studies have
1 c2 j% A8 C* m+ i7 ]8 Tidentified additional transcriptional modulators that bind to
/ W% _9 g! A% T$ e" n  [chromatin near sites occupied by Oct4, Sox2 and Nanog. This
- _: m* O0 e" ~7 ]suggests that the combinatorial control of gene transcription
0 A% M- Y! a5 T* [. @% vmight be fundamental to the ES cell state. Here we discuss how. b$ P6 _/ j( p5 P5 [
these observations advance our understanding of the% P( r" x/ ?% k, {& @
transcription factor network that controls pluripotent identity5 j6 R1 h# W) J0 }1 x* k) s
and highlight unresolved issues that arise from these studies.

carolshen

下了 非常感谢