The transcriptional foundation of pluripotency

argonaute

A fundamental goal in biology is to understand the molecular9 b  P/ m) y0 I5 k; J# [' {
basis of cell identity. Pluripotent embryonic stem (ES) cell
, h# `# D+ i, [7 E3 W! d; yidentity is governed by a set of transcription factors centred on
) J$ v9 ]$ ]; a" p/ k; T+ w3 R) jthe triumvirate of Oct4, Sox2 and Nanog. These proteins often
( r1 g7 b# Q* k- b0 d) B# Xbind to closely localised genomic sites. Recent studies have, }1 W8 Y/ u0 w! u4 |$ a+ B
identified additional transcriptional modulators that bind to
  {# I) c( S. z2 e1 H- mchromatin near sites occupied by Oct4, Sox2 and Nanog. This
" x" D, n8 p" v- Jsuggests that the combinatorial control of gene transcription! u2 a( y, [- s
might be fundamental to the ES cell state. Here we discuss how
5 J, T5 T+ I7 }' @1 ~( o* R  i0 Pthese observations advance our understanding of the/ [: R% i* z9 }  A$ l4 J: D+ ^
transcription factor network that controls pluripotent identity
% O3 M0 [' c8 z* F1 b' Rand highlight unresolved issues that arise from these studies.

carolshen

下了 非常感谢