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本帖最后由 细胞海洋 于 2011-2-9 08:15 编辑 # r" H; J V6 ^/ u8 U, J
7 J5 r1 _$ u& j, D; {2 N1 |. ?最近浏览期刊，发现2008年Cell杂志有一期干细胞研究的综述，内容非常全面，感觉对大家非常有用，可以作为教材来研究学习。下载时把文章的补充材料也下下来，供大家学习。
4 Y3 y% ^& `+ Z+ D* |Stem cells have two remarkable abilities: they can self-renew to keep the stem cell pool replenished, and' @$ e: W7 ~* R& q8 K" ~" i
they can differentiate into a wide variety of cell types. This stunning biological duality intrigues not only
# }6 m+ x) I- {& W: ^, Pthose interested in the basic mechanisms of development, differentiation, and reprogramming, but; I3 R) ?- l+ X, Z: A" w
also those who seek to use stem cells therapeutically to replace lost or damaged tissue. But when did ?; A" s5 I1 M3 @1 q) r0 f U0 E# q
the stem cell revolution start? It was back in the 1960s that two Canadian researchers, Ernest A. McCulloch
, m+ c' R# r: y3 Land James E. Till, launched the field of stem cell research with their groundbreaking work on the hematopoietic9 {% z* E+ V; ^
stem cells of mouse bone marrow. By designing clonogenic assays to measure stem cell differentiation
( ?+ p% m7 `& j* p7 g0 Tin vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and+ p5 I' g5 G# v( K, O, B! a+ J# x9 V
McCulloch defined the hallmark characteristics of stem cells.
( z% @$ ^( I( ?The field of stem cell research has come a long way in 50 years, as we hope will be apparent from this" w% p' t% {+ Y" L1 K! a
year’s Special Review Issue. Our goal in this issue is to highlight the remarkable biological features of
. S' b) ?" t3 H- G- m4 N+ l7 Estem cells, the molecular pathways that control these characteristics, and the ways in which these enigmatic
- Z1 H% W" E% L5 p+ C. L: wcells can be exploited for cell replacement therapy. We would like to thank the many distinguished
& ^2 r% H4 g- k) u% A2 fexperts who contributed their time and efforts as authors and reviewers to make this special issue on; |2 \1 _& Y) a8 w6 _4 ?+ l
stem cells informative, thought-provoking, and timely. We hope that this collection of articles conveys
7 o0 f5 k6 D! O5 W5 j" V. w* Athe excitement and promise of stem cell research, as we enter a new era of possibility. |
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发表于 2011-2-8 23:40
发表于 2011-2-9 09:33
