间充质干细胞治疗annl rev 2010 “Mesenchymal Stem Cells as Therapeutics”

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间充质干细胞治疗较为详尽的综述，必备学习资料！8 |/ |/ Z/ _3 T) V
Mesenchymal Stem Cells as TherapeuticsMesenchymal stem cells (MSCs) are multipotent cells that are being clini-cally explored as a newtherapeutic for treating a variety of immune-mediated, V0 v9 O7 h6 k, {8 S
diseases. First heralded as a regenerative therapy for skeletal tissue repair,MSCs have recently been shown tomodulate endogenous tissue and immune/ D8 p) t/ c& z) \. m
cells. Preclinical studies of the mechanism of action suggest that the ther-apeutic effects afforded by MSC transplantation are short-lived and related6 m" k7 v- k6 e8 m! t
to dynamic, paracrine interactions betweenMSCs and host cells. Therefore,representations of MSCs as drug-loaded particles may allow for pharma-* ?; b% y+ h+ d- u' _
cokinetic models to predict the therapeutic activity of MSC transplants as a function of drug delivery mode. By integrating principles of MSC biology,
' G, b" X  i) j& o4 Htherapy, and engineering, the field is armed to usher in the next generation of stem cell therapeutics