间充质干细胞治疗annl rev 2010 “Mesenchymal Stem Cells as Therapeutics”

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间充质干细胞治疗较为详尽的综述，必备学习资料！7 Z8 {' C) ~& U+ X  F
Mesenchymal Stem Cells as TherapeuticsMesenchymal stem cells (MSCs) are multipotent cells that are being clini-cally explored as a newtherapeutic for treating a variety of immune-mediated
8 i8 |* f5 o! e$ y7 Bdiseases. First heralded as a regenerative therapy for skeletal tissue repair,MSCs have recently been shown tomodulate endogenous tissue and immune. q) G* B3 @3 v& j# M
cells. Preclinical studies of the mechanism of action suggest that the ther-apeutic effects afforded by MSC transplantation are short-lived and related
# `+ ^0 Y8 a$ q! \1 L8 Xto dynamic, paracrine interactions betweenMSCs and host cells. Therefore,representations of MSCs as drug-loaded particles may allow for pharma-- l/ v" E. @- i7 A+ y
cokinetic models to predict the therapeutic activity of MSC transplants as a function of drug delivery mode. By integrating principles of MSC biology,0 r# V  P( k( b0 o
therapy, and engineering, the field is armed to usher in the next generation of stem cell therapeutics