SOX2阳性成体干细胞和前体细胞对于小鼠组织再生及存活至关重要

goodboy

SOX2转录因子可维持胚胎细胞的多潜能性并调控胎儿发育过程中表皮的形成。但SOX2对成体组织的作用却仍未可知，在此作者证实SOX在多种之前未报道过的上皮细胞中有所表达，其中包括胃、子宫颈、肛门、睾丸、晶状体及多种腺体。遗传谱系示踪技术及移植实验证实：这些组织中表达SOX2的细胞会持续产生成熟细胞并保持其自我更新及分化潜能。与这些实验相一致，小鼠中表达SOX2细胞的缺失会导致上皮组织稳态的改变并有致死作用。发育命运图谱显示成体中表达SOX2的细胞来源于胎儿中表达SOX2的细胞。因此其结果在多种外胚层及内胚层组织中鉴定到表达SOX2的细胞，而且其对于正常组织的再生及存活是至关重要的。" H3 T, B- |1 @% s  Z
Article
5 N& f4 Z$ Q6 [# _/ T4 XSox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice
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- ]- z7 N. C/ f  J- f( l& g9 }The transcription factor Sox2 maintains the pluripotency of early embryonic cells and regulates the formation of several epithelia during fetal development. Whether Sox2 continues to play a role in adult tissues remains largely unknown. We show here that Sox2 marks adult cells in several epithelial tissues where its expression has not previously been characterized, including the stomach, cervix, anus, testes, lens, and multiple glands. Genetic lineage tracing and transplantation experiments demonstrate that Sox2-expressing cells continuously give rise to mature cell types within these tissues, documenting their self-renewal and differentiation potentials. Consistent with these findings, ablation of Sox2+ cells in mice results in a disruption of epithelial tissue homeostasis and lethality. Developmental fate mapping reveals that Sox2+ adult stem cells originate from fetal Sox2+ tissue progenitors. Thus, our results identify Sox2 expression in numerous adult endodermal and ectodermal stem cell compartments, which are critical for normal tissue regeneration and survival.: r: u( r$ [+ ^

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http://www.sciencedirect.com/sci ... i/S1934590911004322

naturalkillerce

回复 goodboy 的帖子
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美国科学家发现Sox2是很多成体干细胞类型的分子标记物：http://www.stemcell8.cn/thread-47577-1-1.html
+ Y# H3 v5 G/ d! {该贴子上面有原文。

haijing12585

这是文章

amberma

  原文

Yedan

说句题外话，Sox2在体细胞表达之前有发现，而且Sox2跟Klf4和Myc一样也是onco的，是在lung and esophageal squamous cell carcinomas发现的。
5 d4 h& Z, w* o$ z$ QP.S.原文我也附在后面了。