PDF电子书：Non-Viral Gene Therapy

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Non-Viral Gene Therapy/ @3 T2 L5 H: S6 S4 C% y* t
Edited by: Xu-bo Yuan
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$ l8 x$ C9 l" S& Z0 }/ VISBN 978-953-307-538-9, Hard cover, 696 pages- J/ c2 w: j  L; X8 n' M* s9 z
Publisher: InTech+ r6 T+ C" |9 }" n
Publication date: November 2011
1 Q/ v4 x- m" l2 v/ GSubject: Gene Therapy
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3 `1 x5 i$ T9 p; T# jThis book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation.
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Table of Contents0 q- }  `9 V+ m) u+ @4 x9 M3 n
Non-Viral Gene Therapy Vectors Carrying Genomic Constructs
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2 t3 B0 r* y1 h, UNon-Viral Delivery Systems in Gene Therapy and Vaccine Development
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Gene Delivery Systems: Tailoring Vectors to Reach Specific Tissues: }+ T7 T1 ~0 [* n) b
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Investigation of Transfection Barriers Involved in Non-Viral Nanoparticulate Gene Delivery in Different Cell Lines+ J" j/ U% r3 e; D

9 F" }, s$ f, _* x) \5 TThe Mechanical Agitation Method of Gene Transfer for Ex-Vivo Gene Therapy
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Gene Therapy of Some Genetic Diseases by Transferring Normal Human Genomic DNA into Somatic Cells and Stem Cells from Patients- b. p' K3 }  `$ C2 O$ u, u
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Non Viral Gene Transfer Approaches for Lysosomal Storage Disorders
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& P: I" B* \) D  _; Q* @- p' QDNA Vaccination by Electrogene Transfer
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4 ?8 k, e8 H9 w" ~& AGene Delivery with Ultrasound and Microbubbles" t, Q+ x0 {# @  N/ p

" b% Y3 a0 K; n# a7 j! |% U; CUltrasound-Mediated Gene Delivery; h# I: B: q0 ^6 R, E) g* D

1 p* N( L/ N: Y) M% J" b# I4 qPolyamine – Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity
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Technological Aspects of Scalable Processes for the Production of Functional Liposomes for Gene Therapy, A# `; d' w: ?7 R/ u* C

5 ?. K9 |$ W; B: uCationic Liposomes in Different Structural Levels for Gene Delivery
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( \* a$ J: T' z1 MNeutral Liposomes and DNA Transfection& `2 a$ p0 Y( Q) L$ r( ^6 Z7 _
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Non-Viral Gene Delivery Systems Based on Cholesterol Cationic Lipids: Structure-Activity Relationships
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Polycation-Mediated Gene Delivery: The Physicochemical Aspects Governing the Process
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" L$ g9 e' y, r& YMedical Polymer-Based Gene Therapy+ T& _3 R0 i; N( M. ?. B- s
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Chitosan and Its Modifications: Are They Possible Vehicles for Gene Therapy?- q+ r1 q+ G, Z1 U* \6 k' x4 t0 u
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Chitosan-DNA/siRNA Nanoparticles for Gene Therapy, r' X4 ^* j; f5 [7 r* @
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Toxicity of Polymeric-Based Non-Viral Vector Systems for Pulmonary siRNA Application; E9 L  ]8 P& S8 t8 U2 m

, u& ]  W' z. N# ?' U: z. O, [( MPAMAM Dendrimer as Potential Delivery System for Combined Chemotherapeutic and MicroRNA-21 Gene Therapy
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1 @3 J' U4 o" k) @; Y/ vNanomedicine Based Approaches to Cancer Diagonsis and Therapy1 C( L' F' u; c/ J, g- B8 w

# ^; u& g0 m6 R7 s* J3 xToxicogenomics of Nonviral Cationic Gene Delivery Nanosystems
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Nano-Particulate Calcium Phosphate as a Gene Delivery System
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" ?, s) S6 P0 o5 a* i- vModular Multifunctional Protein Vectors for Gene Therapy9 M; j3 r8 e5 e6 ?5 ]

4 h' [7 r/ |1 cPeptides as Promising Non-Viral Vectors for Gene Therapy3 G' ~% [  U) o/ |4 _0 X* V. K+ q
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Binding of Protein-Functionalized Entities onto Synthetic Vesicles' D; D7 \& g5 m* H5 s! {

6 m! @. I7 O7 q. w( \Targeting TRAIL Receptors with Genetically- Engineered CD34+ Hematopoietic Stem Cells  A7 h$ s5 F. e7 {( l& A
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Pyrrole-Imidazole Polyamides for Gene Therapy: Bioanalytical Methods and Pharmacokinetics
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