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Non-Viral Gene Therapy
' S( X2 q) O4 A+ I# I; b& W- KEdited by: Xu-bo Yuan
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3 N8 [5 G" ]' E/ H+ r+ O$ ]6 hISBN 978-953-307-538-9, Hard cover, 696 pages
- E, n8 P* q3 KPublisher: InTech" t8 y* e- \4 O# F
Publication date: November 2011; f# L b1 E4 r! |& B
Subject: Gene Therapy3 {" Q, n- \6 z* G7 q- F
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This book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation.1 W6 N. m( n( M9 L5 P
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Table of Contents3 V' N2 u( _9 W
Non-Viral Gene Therapy Vectors Carrying Genomic Constructs
u4 v, ?9 g7 c0 K9 ]$ o5 i1 n B% }2 n5 ?8 S0 g! E
Non-Viral Delivery Systems in Gene Therapy and Vaccine Development
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" R; t+ I. l5 i# `+ }) {Gene Delivery Systems: Tailoring Vectors to Reach Specific Tissues
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Investigation of Transfection Barriers Involved in Non-Viral Nanoparticulate Gene Delivery in Different Cell Lines' `; t. F/ E- p* g
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The Mechanical Agitation Method of Gene Transfer for Ex-Vivo Gene Therapy% B) ^8 `1 l* b1 |" m4 [
6 q5 c s. k3 W0 `4 H" x% {Gene Therapy of Some Genetic Diseases by Transferring Normal Human Genomic DNA into Somatic Cells and Stem Cells from Patients3 h E, _! W- b4 k# b9 R. L
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Non Viral Gene Transfer Approaches for Lysosomal Storage Disorders" P4 w% O+ Y* E' Q6 X8 Q. n
0 N" {9 w; m& S! s3 ^9 ZDNA Vaccination by Electrogene Transfer
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Gene Delivery with Ultrasound and Microbubbles
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Ultrasound-Mediated Gene Delivery
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' y' X' X! d- k; s) M7 i) \" nPolyamine – Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity
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Technological Aspects of Scalable Processes for the Production of Functional Liposomes for Gene Therapy
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Cationic Liposomes in Different Structural Levels for Gene Delivery
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9 Z0 k9 r8 [8 s1 |1 G. K( \Neutral Liposomes and DNA Transfection9 j2 S7 b. b( m+ F' G
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Non-Viral Gene Delivery Systems Based on Cholesterol Cationic Lipids: Structure-Activity Relationships
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Polycation-Mediated Gene Delivery: The Physicochemical Aspects Governing the Process' q& e$ I4 b( ?# g6 M9 B" B( H
( }" }- Y0 ]0 \, Y2 f8 e; vMedical Polymer-Based Gene Therapy: u5 D0 h" l9 f& E. d( J. a3 ^* N
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Chitosan and Its Modifications: Are They Possible Vehicles for Gene Therapy?+ d5 {# {: ]( p, m$ x0 d% U9 s* Y
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Chitosan-DNA/siRNA Nanoparticles for Gene Therapy
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$ Y! |4 p d3 P' s: f( I. eToxicity of Polymeric-Based Non-Viral Vector Systems for Pulmonary siRNA Application
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PAMAM Dendrimer as Potential Delivery System for Combined Chemotherapeutic and MicroRNA-21 Gene Therapy* C' v, v, c* x% o) U; B
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Nanomedicine Based Approaches to Cancer Diagonsis and Therapy$ i3 B* g* H4 K: ^7 L
( v) A+ g/ R6 v2 z9 q( T" O3 s* NToxicogenomics of Nonviral Cationic Gene Delivery Nanosystems9 l) F) E( S' E" p1 F+ y
w+ B, M5 U# SNano-Particulate Calcium Phosphate as a Gene Delivery System
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Modular Multifunctional Protein Vectors for Gene Therapy! v8 K1 A" `7 [7 F) L. `
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Peptides as Promising Non-Viral Vectors for Gene Therapy
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, H( n7 v/ P v) g2 RBinding of Protein-Functionalized Entities onto Synthetic Vesicles
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Targeting TRAIL Receptors with Genetically- Engineered CD34+ Hematopoietic Stem Cells
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/ S' W |/ u5 }Pyrrole-Imidazole Polyamides for Gene Therapy: Bioanalytical Methods and Pharmacokinetics
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