PDF电子书：Non-Viral Gene Therapy

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Non-Viral Gene Therapy/ I( ~  G) \- [$ h- f% W* L
Edited by: Xu-bo Yuan6 u% D4 f' ^) M$ ?* N- B
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ISBN 978-953-307-538-9, Hard cover, 696 pages# W3 T% A1 J; ]6 M$ Z5 J! ^% w
Publisher: InTech
2 g: T! F* ]' b% a+ v8 HPublication date: November 2011. l+ L( Y! s$ z$ b" P  V4 G  O5 h( D
Subject: Gene Therapy
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( k/ t- K+ O9 ]+ }. b1 b+ D! I. ]This book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation./ C  D9 Y6 X2 e$ {
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Table of Contents
# Q% @% b+ w9 @7 n1 b: qNon-Viral Gene Therapy Vectors Carrying Genomic Constructs
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2 g* }- t) f: ?Non-Viral Delivery Systems in Gene Therapy and Vaccine Development, ?8 h0 i( O* \1 N  d( D

1 N# m- D$ g1 t) I/ oGene Delivery Systems: Tailoring Vectors to Reach Specific Tissues
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Investigation of Transfection Barriers Involved in Non-Viral Nanoparticulate Gene Delivery in Different Cell Lines7 q: a& H; R% G) |% z
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The Mechanical Agitation Method of Gene Transfer for Ex-Vivo Gene Therapy
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Gene Therapy of Some Genetic Diseases by Transferring Normal Human Genomic DNA into Somatic Cells and Stem Cells from Patients, M6 S: _7 x* D' x
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Non Viral Gene Transfer Approaches for Lysosomal Storage Disorders3 b# U' H- V8 R: C  c/ ?' S& q1 _

$ A, O8 j+ Y- a+ w4 Z4 _DNA Vaccination by Electrogene Transfer
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Gene Delivery with Ultrasound and Microbubbles
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" I7 v- q$ t  n! l" CUltrasound-Mediated Gene Delivery
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, ~9 r, Y; ?# K; n4 ?# w5 ?! mPolyamine – Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity
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1 j( p) n0 j( J; v. f' K. F& m- STechnological Aspects of Scalable Processes for the Production of Functional Liposomes for Gene Therapy
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Cationic Liposomes in Different Structural Levels for Gene Delivery
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Neutral Liposomes and DNA Transfection
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# M4 P4 v& X) Q$ r) SNon-Viral Gene Delivery Systems Based on Cholesterol Cationic Lipids: Structure-Activity Relationships
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Polycation-Mediated Gene Delivery: The Physicochemical Aspects Governing the Process. k* D& E& k, K$ N2 @: [

" F/ n- q, v% Y" r8 Q: BMedical Polymer-Based Gene Therapy0 A8 B1 g+ l% X: V; T0 D

2 z: i% g! p; }8 X, }+ j/ w4 ]Chitosan and Its Modifications: Are They Possible Vehicles for Gene Therapy?
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Chitosan-DNA/siRNA Nanoparticles for Gene Therapy
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Toxicity of Polymeric-Based Non-Viral Vector Systems for Pulmonary siRNA Application
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PAMAM Dendrimer as Potential Delivery System for Combined Chemotherapeutic and MicroRNA-21 Gene Therapy
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, \& o* D/ R" e7 S. }. \9 W6 uNanomedicine Based Approaches to Cancer Diagonsis and Therapy
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  G8 Q2 n) [  x. b& N6 ?) t5 fToxicogenomics of Nonviral Cationic Gene Delivery Nanosystems, l' u( y/ Q& O9 _& ^) c/ h* Y

4 q; \/ G; s& d" f% YNano-Particulate Calcium Phosphate as a Gene Delivery System: N% q% q6 T) d# I6 u

  U7 q  G& w) a3 i6 F: w+ p# Z. u* JModular Multifunctional Protein Vectors for Gene Therapy1 ~+ o: E  E( K6 q7 G& s2 ~% s% W+ _

9 w" h7 h, u) U% W; i5 Y4 t2 aPeptides as Promising Non-Viral Vectors for Gene Therapy# y7 M' P& J) E6 e& i# i6 c

) m  U: r2 w( t) ]Binding of Protein-Functionalized Entities onto Synthetic Vesicles
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% r' F- Z* V8 vTargeting TRAIL Receptors with Genetically- Engineered CD34+ Hematopoietic Stem Cells
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Pyrrole-Imidazole Polyamides for Gene Therapy: Bioanalytical Methods and Pharmacokinetics3 e/ ]7 E, \. N  b3 b3 m& A

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