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Non-Viral Gene Therapy
* e" b2 H) n8 y" }" J" tEdited by: Xu-bo Yuan9 J6 h2 d2 q9 n$ h2 L5 G% ]8 ^
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ISBN 978-953-307-538-9, Hard cover, 696 pages, b4 L {) c6 ?/ m4 I
Publisher: InTech
5 s1 Q3 j: e2 K0 UPublication date: November 2011
7 }$ O ]% i. VSubject: Gene Therapy2 O& h9 j- [/ t3 C
1 J! H/ |' x8 B9 wThis book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation.
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Table of Contents
' o) a/ j) K. H7 `' l% X1 F5 wNon-Viral Gene Therapy Vectors Carrying Genomic Constructs
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Non-Viral Delivery Systems in Gene Therapy and Vaccine Development4 B0 e2 I. f( ~( ?+ {
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Gene Delivery Systems: Tailoring Vectors to Reach Specific Tissues
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3 p% a/ Z& o1 k8 H. d# }0 WInvestigation of Transfection Barriers Involved in Non-Viral Nanoparticulate Gene Delivery in Different Cell Lines
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7 D' y# J. r+ F0 d8 f& eThe Mechanical Agitation Method of Gene Transfer for Ex-Vivo Gene Therapy
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( i1 H/ s. F. c2 IGene Therapy of Some Genetic Diseases by Transferring Normal Human Genomic DNA into Somatic Cells and Stem Cells from Patients
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% u6 U R, c, Y, mNon Viral Gene Transfer Approaches for Lysosomal Storage Disorders
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DNA Vaccination by Electrogene Transfer
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' r! @4 I. c# ^# CGene Delivery with Ultrasound and Microbubbles
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8 U/ L3 l. ? \5 A; p9 ?& xUltrasound-Mediated Gene Delivery9 w0 M0 W& @$ [$ K5 {/ ^4 t4 K
5 b0 ^$ E- b4 t4 C2 o PPolyamine – Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity2 \0 \ T- J, l5 Z9 D
- X5 ~+ C: p6 u" H, J1 m. HTechnological Aspects of Scalable Processes for the Production of Functional Liposomes for Gene Therapy$ w( g" d" Y; u
, H+ C4 \4 D! _8 JCationic Liposomes in Different Structural Levels for Gene Delivery7 D8 k. \! ]* p+ x% z4 T
/ f; Y; H: o& [& U7 B6 BNeutral Liposomes and DNA Transfection
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Non-Viral Gene Delivery Systems Based on Cholesterol Cationic Lipids: Structure-Activity Relationships7 q& H5 N P3 m
9 V' U; F9 p; ~$ i# ]# J7 J$ ~Polycation-Mediated Gene Delivery: The Physicochemical Aspects Governing the Process
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Medical Polymer-Based Gene Therapy
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Chitosan and Its Modifications: Are They Possible Vehicles for Gene Therapy?% b3 g4 c3 ?5 n4 {
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Chitosan-DNA/siRNA Nanoparticles for Gene Therapy
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4 d/ m6 X0 |. ~) p2 s0 ^" CToxicity of Polymeric-Based Non-Viral Vector Systems for Pulmonary siRNA Application4 }3 R! X! w4 Q1 D/ o' d
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PAMAM Dendrimer as Potential Delivery System for Combined Chemotherapeutic and MicroRNA-21 Gene Therapy
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Nanomedicine Based Approaches to Cancer Diagonsis and Therapy
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; S8 S9 Z' k; V) l% V2 Q nToxicogenomics of Nonviral Cationic Gene Delivery Nanosystems
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0 `( j& \$ c% ?5 D; t$ E1 y% DNano-Particulate Calcium Phosphate as a Gene Delivery System1 i0 Q6 C$ p W9 p# L* @$ h, q
8 \) o& g* F: r# _0 @Modular Multifunctional Protein Vectors for Gene Therapy
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Peptides as Promising Non-Viral Vectors for Gene Therapy5 U6 m0 w- T8 f0 v/ F
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Binding of Protein-Functionalized Entities onto Synthetic Vesicles
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" Z. N1 x2 g1 U ^Targeting TRAIL Receptors with Genetically- Engineered CD34+ Hematopoietic Stem Cells
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; ]- V( w3 z0 ~; _Pyrrole-Imidazole Polyamides for Gene Therapy: Bioanalytical Methods and Pharmacokinetics# @6 x5 I. u: ~
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