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RESEARCH HIGHLIGHTS
& H( b7 {. e# g5 vGlia: Astrocytes know their place/ G" ^$ R) @# Y2 `) _ k; i' w
Neural development: A fruitless sexual switch
: Q3 |1 A. V- n% X% C; x3 _6 kAxon degeneration: A new pathway emerges3 h+ J# I! g/ a/ t4 p" C( `
Techniques: Propriospinal neurons — old but not forgotten. n) @( g" `9 N8 V" E' T v+ N
Cognitive neuroscience: Adapting to cognitive load
" l/ c; d3 A7 Y l, B: ENeuroanatomy: Out with the old (model)
% n0 ]1 q3 n1 F' P2 o2 gNeurodevelopmental disorders: TSCerebellar autism in mice, X8 |/ x# r- g# M. K7 T) f
IN BRIEF2 A. M3 Q# ]* R& |$ ?; \
Neuroimmunology: Harnessing adaptive immunity for AD; T/ D: c+ A) n+ M3 O
Neurological disorders: Focus on miR-134 for seizures
4 r% t+ y. h& HSynaptic physiology: No return for spiking axons
* }; s- }, w' X9 h2 I& Y& w9 C3 [Neurological disorders: SHANK2 misbehaves in autism9 n# Z# L9 |/ a0 n( ]& j
Glia: Glial AMPA receptors finely tune motor behaviour
" e9 g( \# X0 e; ?; p2 r+ s1 mLearning and memory: Listen while you sleep
' z/ R3 ]; T: Y; c# B1 EAddiction: Targeting nicotine
/ [) R) b2 s8 q0 VSensory systems: The UV regulator
# e% U2 D3 E9 T0 h! y4 q. H% hPROGRESS
1 ?1 x4 s y) R$ A6 h0 b( L0 |& zControl of central auditory processing by a brain-generated oestrogen
5 \7 ^3 n6 ]* L% ^1 ]1 FRaphael Pinaud & Liisa A. Tremere' G" e3 d7 {" M' [: u3 @
Recent studies show that oestradiol, the classic female oestrogen, can be locally synthesized by central auditory neurons to rapidly modulate neuronal physiology and auditory-based behaviours in both sexes. Pinaud and Tremere review these findings, which indicate that oestradiol is an important, novel modulator of hearing function.' p4 ?! m. W- E* `8 L
REVIEWS
8 c5 O( s4 T. h3 R6 I+ {Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease8 o3 n2 _/ h, {: @. r: e" v" Y
Irfan A. Qureshi & Mark F. Mehler4 U5 { B# m" Q+ s# m+ R* G
The recent characterization of non-coding RNAs and their astonishingly diverse functions has led to a radical shift in our understanding of how the genome influences neuronal function. In this Review, Qureshi and Mehler describe the numerous classes of non-coding RNAs and how they might contribute to neuronal physiology and disease.0 B& D/ U. @" y, A- X
Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond2 v! N: j+ e0 R' ] X" w
Annette C. Dolphin4 U0 S. l5 P, X! S4 l
The α2δ and β subunits of voltage-gated calcium channels (VGCCs) modulate the biophysical properties and trafficking of such channels. In this Review, Annette Dolphin examines the traditional roles of these auxillary subunits and their involvement in neuronal processes that are not linked to VGCC function.2 }7 O4 f# j5 V Q
Multisensory brain mechanisms of bodily self-consciousness; W! L9 @: J4 P% H9 |" ]6 a/ X
Olaf Blanke$ p' {" P4 ^1 D) A
Bodily self-consciousness includes the conscious experience of identifying with the body, of where 'I' am in space, and of the perspective from where 'I' perceive the world. Olaf Blanke discusses the cortical mechanisms that underlie these experiences, highlighting data from neuroimaging, neurology and virtual reality.
) F( c+ G9 V J$ ]% n& E/ \; ^* T4 LKnowing how much you don't know: a neural organization of uncertainty estimates& e4 w: N) f G/ p
Dominik R. Bach & Raymond J. Dolan% S& {. k0 P- q' J3 F0 L
Decision making is influenced by uncertainty, which arises from internal and external noise. A fundamental question is how uncertainty is encoded in the brain and how it influences behaviour. In this Review, Bach and Dolan integrate several theoretical concepts about uncertainty into a hierarchical decision-making framework.
2 N) I4 b# X, c2 L, g: U/ ^% O8 ]; NPERSPECTIVES$ H. f2 D9 I# e# j( Y
OPINION7 H- _5 f9 W4 T, |; I! U- _, M# P
Concept cells: the building blocks of declarative memory functions9 Q- j2 n% ]( i; x* f# i% L% }
Rodrigo Quian Quiroga
1 N7 p% ?1 y2 q& @9 {Neurons in the human medial temporal lobe respond in a selective and abstract manner to particular persons or objects. Rodrigo Quian Quiroga argues that these 'concept cells' are crucial for memory functions and the transition between related concepts that leads to the flow of consciousness.# R S: p) s. Y( F+ r/ I) @) q
Corrigendum: Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair" N' S ~4 T- M& a
Hosung Jung, Byung C. Yoon & Christine E. Holt+ O& E( S9 A7 C" m+ Q. @2 p u
+ a4 F* p% b3 J/ ~: \$ r2 Y0 sErratum: Will the real multiple sclerosis please stand up?
/ K! j! B$ Y) P$ Q$ \: GPeter K. Stys, Gerald W. Zamponi, Jan van Minnen & Jeroen J. G. Geurts V6 Q) A) e& @) d$ D0 k' ?
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发表于 2012-8-10 23:23
发表于 2012-8-14 08:48
