PDF电子书：Nanotechnology for Nucleic Acid Delivery (Springer MMB-Vol948, 2013)

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& `; X) V; a! ]8 M5 CNanotechnology for Nucleic9 a! a( J$ i9 \2 F5 b
Acid Delivery) x1 X7 L& @7 m) x; }) A7 G
Methods and Protocols/ m: }  H, H# e5 w
Edited by" e' a7 U) q9 p8 p
6 v" b% ]8 H2 e9 x' l( y
Manfred Ogris4 c( D0 t8 d+ U2 K0 u2 r" k
Department of Pharmacy,
' N! t! J5 }+ U, Y5 a- I7 A4 cLudwig-Maximilians-University Munich, Munich, Germany( S) |! V* j! t7 O
David Oupicky
$ I# d8 U4 V; P7 ]" CDepartment of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA
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Contents0 ]) Z/ y2 x7 r' i. Y
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v, x1 G" y$ M' b3 r
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
) `& `, t. X' y' \' e4 b% m1 Toxicological Aspects for Nanomaterial in Humans . . . . . . . . . . . . . . . . . . . . . 1# D5 F( a, v# ?7 V0 T9 c
Maria Dusinska, Zuzana Magdolenova, and Lise Marie Fjellsbø
3 D' i+ e# Z7 I2 G5 I7 |2 ^" q1 `8 S2 Lactate Dehydrogenase Assay for Assessment of Polycation Cytotoxicity . . . . . 13
* w, ], F6 R& f$ D) h3 zLadan Parhamifar, Helene Andersen, and S. Moein Moghimi/ _6 B) E1 n4 e9 P$ d# [) Y
3 Combined Fluorimetric Caspase 3/7 Assay and Bradford Protein& M* i- w, v$ K/ q) R
Determination for Assessment of Polycation-Mediated Cytotoxicity . . . . . . . . 23
& Q7 w5 L  C7 \Anna K. Larsen, Arnaldur Hall, Henrik Lundsgart, and S. Moein Moghimi/ C0 o4 r5 G2 F5 ]! D: Z
4 Anti-PEG IgM Production via a PEGylated Nano-Carrier System2 L/ [- Y5 F, v9 I: S9 z' w
for Nucleic Acid Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
$ s  o" K4 v# hMasako Ichihara, Naoto Moriyoshi, Amr S. Abu Lila, Tatsuhiro Ishida,- Q! J0 Z3 P9 r8 c7 N2 Q4 D
and Hiroshi Kiwada
# ]# w" y+ W! z( l4 }8 R1 ?5 Near-Infrared Optical Imaging of Nucleic Acid Nanocarriers In Vivo . . . . . . . 49
, ~5 A# D& H, a& d: F" j( k1 c6 JClaire Rome, Julien Gravier, Marie Morille, Gilles Divita,: g+ m5 X( O- |) w; i
Anne-Laure Bolcato-Bellemin, Véronique Josserand, and Jean-Luc Coll
; p5 ~) I2 k& [  l5 l6 Lipids for Nucleic Acid Delivery: Synthesis and Particle Formation . . . . . . . . . 67/ m4 o2 ]) u3 g. g5 Q# _- s
Michel Bessodes and Nathalie Mignet  v. T& S' R# S5 k0 S" D- X0 J
7 Histidine-Rich Cationic Amphipathic Peptides for Plasmid DNA
- k& U) s  [( X1 u6 L% Band siRNA Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
" M" @. L* c: BAntoine Kichler, A. James Mason, Arnaud Marquette,: N3 ]. f# g0 Y- h8 R* X# E
and Burkhard Bechinger
7 F: w+ K/ Z% l3 G/ Z8 Synthesis of Polyethylenimine-Based Nanocarriers for Systemic Tumor: G+ t6 C; S/ ?8 h
Targeting of Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1052 ^* b5 h. ^+ i/ N# c8 K% v. f, V+ A
Wolfgang Rödl, David Schaffert, Ernst Wagner, and Manfred Ogris6 k6 @5 ^* a% y) c
9 Synthesis of Bioreducible Polycations with Controlled Topologies . . . . . . . . . . 1218 l6 @7 y" D8 I8 j1 L
Ye-Zi You, Jun-Jie Yan, Zhi-Qiang Yu, and David Oupicky
5 b, p5 a  k; S, D9 R+ v10 Lyophilization of Synthetic Gene Carriers . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133( h" C) e2 s/ V
Julia Christina Kasper, Sarah Küchler, and Wolfgang Friess
( }( i' z9 t' M1 u. H3 v/ i11 Surface-and Hydrogel-Mediated Delivery of Nucleic Acid Nanoparticles . . . . . 149
  T/ x3 Y0 _( B/ vAngela K. Pannier and Tatiana Segura- G" [; d* |8 F) S
12 Layer-by-Layer Assembled Gold Nanoparticles for the Delivery
) [* U1 I$ ?; h* {; c* ~8 eof Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1719 c. B8 ~8 W% a! b9 @
Eva-Christina Wurster, Asmaa Elbakry, Achim Göpferich,
: S9 v2 U; i; I+ Nand Miriam Breunig
' O: ~1 ?4 x, O2 N( x& p7 Nviii Contents
$ d  |; s8 k2 k* q13 In Situ AFM Analysis Investigating Disassembly of DNA Nanoparticles
! b) _5 P! Z, k! m; O8 c/ f# }and Nano-Films . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1833 u0 R1 T4 d9 F. r; _/ K+ Z
Yi Zou, Lei Wan, Jenifer Blacklock, David Oupicky, and Guangzhao Mao
0 i9 n: `: P% L! ~4 C( p14 Enhancing Nucleic Acid Delivery with Ultrasound and Microbubbles . . . . . . . 195
6 Z" w( g& K# L* w- {+ `Steven K. Cool, Bart Geers, Ine Lentacker, Stefaan C. De Smedt,$ |$ J1 ?7 q. U; P
and Niek N. Sanders0 E& G% H7 \4 f% x
15 Magnetic and Acoustically Active Microbubbles Loaded with Nucleic Acids0 b; x3 L6 V' ~5 j+ N5 X
for Gene Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205$ l7 t7 h: J4 f& L8 q/ [; C
Dialechti Vlaskou, Christian Plank, and Olga Mykhaylyk: g" N# `" e! L6 u" v
16 Synthesis of Lipidic Magnetic Nanoparticles for Nucleic Acid Delivery . . . . . . 243' w# E  l4 u$ I! S* `* Y
Yoshihisa Namiki
8 y7 j/ O3 [, ^. U1 ~17 Lipopeptide Delivery of siRNA to the Central Nervous System . . . . . . . . . . . . 251
& {  K3 G) I# ]8 O5 J9 R, r+ RMark D. Zabel5 R; w* L9 Y" z, S, J: w. C- |! F
18 Flow Cytometry-Based Cell Type-Speci fi c Assessment of Target Regulation
) m: H$ x3 S+ O3 p& w& |7 d- u9 U' b# Eby Pulmonary siRNA Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263- W9 Q/ j# p; L3 b* ^6 \0 L4 O
Olivia M. Merkel, Leigh M. Marsh, Holger Garn, and Thomas Kissel. k' S' m. `. `" r9 _0 u
19 Liver-Targeted Gene Delivery Through Retrograde Intrabiliary Infusion. . . . . 275
4 H3 b; `4 m, qXuan Jiang, Yong Ren, John-Michael Williford, Zhiping Li,
7 t. j  e7 B% R+ w% ?" a8 I! u' ^and Hai-Quan Mao& O+ Z: h* m) V% l" b
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285
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