PDF电子书：Nanotechnology for Nucleic Acid Delivery (Springer MMB-Vol948, 2013)

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9 \; p! r, H. @0 j' o* r7 d  E4 r% [Nanotechnology for Nucleic: ~/ x: [" {( \0 h
Acid Delivery5 M, [, e- r3 p5 P# A
Methods and Protocols
* ^4 x2 F8 m' v6 O9 eEdited by7 {) s, _3 W9 V4 V  M: S. r

) F, C- [; w1 Z6 W. wManfred Ogris
1 b: X5 N0 @5 z4 V. N# {) `Department of Pharmacy,; w1 G0 {* B, E8 b& u
Ludwig-Maximilians-University Munich, Munich, Germany
- N7 z- u+ t- u8 l# M& dDavid Oupicky# W0 ?/ O7 ^- a; o- r& K4 B
Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA' O& b, _* R. c9 w0 W/ ^: F. B
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Contents
& b2 ?. n6 c3 ^# Z  ^' UPreface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v( o+ h+ r- M6 x1 w+ s3 l+ e6 s) B
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
4 R, `, T, |+ J2 T: q# @3 `1 Toxicological Aspects for Nanomaterial in Humans . . . . . . . . . . . . . . . . . . . . . 1
2 q' S, V% J. h  u- Z+ j# V. V2 aMaria Dusinska, Zuzana Magdolenova, and Lise Marie Fjellsbø
/ ~2 v7 z+ N& v. U- R2 Lactate Dehydrogenase Assay for Assessment of Polycation Cytotoxicity . . . . . 132 |. U- ?0 z( X/ O- Q8 }- z  g
Ladan Parhamifar, Helene Andersen, and S. Moein Moghimi
% a3 l  s( y4 w' j, y" t# f3 Combined Fluorimetric Caspase 3/7 Assay and Bradford Protein- `* U6 Q. T4 J, c7 v0 a6 B/ y  y
Determination for Assessment of Polycation-Mediated Cytotoxicity . . . . . . . . 238 s& y- i4 D8 u# o6 I2 P5 N
Anna K. Larsen, Arnaldur Hall, Henrik Lundsgart, and S. Moein Moghimi' ~. V% u6 E; e8 ]; ^# ^# B
4 Anti-PEG IgM Production via a PEGylated Nano-Carrier System( W3 f: q9 [; Q3 |6 ]9 ?
for Nucleic Acid Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
8 G& V3 X. K; l% F" dMasako Ichihara, Naoto Moriyoshi, Amr S. Abu Lila, Tatsuhiro Ishida,) Q8 w4 C& z5 C& \. N7 z3 m2 Y. F1 {/ R8 j
and Hiroshi Kiwada
& `4 a' m9 V5 G% S1 G# J! O; Y5 Near-Infrared Optical Imaging of Nucleic Acid Nanocarriers In Vivo . . . . . . . 49! I' {; p% f7 W# A3 E! u! i
Claire Rome, Julien Gravier, Marie Morille, Gilles Divita,# v5 F/ w$ h7 D" c, k
Anne-Laure Bolcato-Bellemin, Véronique Josserand, and Jean-Luc Coll* g% [$ P5 s% x7 v% E* C; k
6 Lipids for Nucleic Acid Delivery: Synthesis and Particle Formation . . . . . . . . . 67
, d3 J2 K% p% K) tMichel Bessodes and Nathalie Mignet, v0 V2 K6 x! c2 q
7 Histidine-Rich Cationic Amphipathic Peptides for Plasmid DNA! v4 {( L; y' W) @$ Q" W$ L! i
and siRNA Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
0 `8 x' u  m/ H6 [6 OAntoine Kichler, A. James Mason, Arnaud Marquette,; V9 m- H& q. U' T8 c% M
and Burkhard Bechinger
$ l/ o' N4 f7 w& v9 Q7 v% P7 I( y8 `8 Synthesis of Polyethylenimine-Based Nanocarriers for Systemic Tumor
9 ~8 s" J* H% ^/ Q0 {Targeting of Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1052 d8 I; N+ `# p  ^1 _6 R& j
Wolfgang Rödl, David Schaffert, Ernst Wagner, and Manfred Ogris+ B3 ?7 I6 S4 ]0 q
9 Synthesis of Bioreducible Polycations with Controlled Topologies . . . . . . . . . . 1216 J  f6 V! ]$ [: g- g; Q8 W9 J- U: o
Ye-Zi You, Jun-Jie Yan, Zhi-Qiang Yu, and David Oupicky
0 E7 S- \5 u+ B1 A/ B10 Lyophilization of Synthetic Gene Carriers . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133# a6 F, @! [; y: t* ^8 K
Julia Christina Kasper, Sarah Küchler, and Wolfgang Friess1 Y7 o9 ?, j" I9 w) |+ G) x
11 Surface-and Hydrogel-Mediated Delivery of Nucleic Acid Nanoparticles . . . . . 149
: I* H2 d+ M5 @+ h1 F5 D( V  yAngela K. Pannier and Tatiana Segura
! g1 F6 m8 L2 g) C) _1 {1 [+ W12 Layer-by-Layer Assembled Gold Nanoparticles for the Delivery
& U, j$ R1 g. hof Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171  G( W0 `' o# l7 h8 S( ]( e
Eva-Christina Wurster, Asmaa Elbakry, Achim Göpferich,* Y6 m7 m/ ?9 ~8 x( W5 r
and Miriam Breunig
: Z$ o) u: H+ L6 W8 ?5 |8 gviii Contents, Y" t# H& w& j/ @. ]
13 In Situ AFM Analysis Investigating Disassembly of DNA Nanoparticles4 o2 W6 F& e( P+ i* U8 B, N" `
and Nano-Films . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183
# h$ ~4 M  a8 y  C" lYi Zou, Lei Wan, Jenifer Blacklock, David Oupicky, and Guangzhao Mao
6 q5 M- S2 W9 d: A9 j14 Enhancing Nucleic Acid Delivery with Ultrasound and Microbubbles . . . . . . . 195
# ^. Y; I4 _1 eSteven K. Cool, Bart Geers, Ine Lentacker, Stefaan C. De Smedt,0 Z7 k# d8 l: c* D3 Q9 Y2 T/ j
and Niek N. Sanders  ?* R4 z% y5 f" p  R
15 Magnetic and Acoustically Active Microbubbles Loaded with Nucleic Acids9 I# d  M. y+ f
for Gene Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
  r8 X( l4 O) T# o" cDialechti Vlaskou, Christian Plank, and Olga Mykhaylyk
# s# ~8 {1 T1 q# c/ g9 c16 Synthesis of Lipidic Magnetic Nanoparticles for Nucleic Acid Delivery . . . . . . 243
+ x$ ~  a7 ~# F' z7 K, ~" N. [Yoshihisa Namiki/ L$ z: S8 x# W! o
17 Lipopeptide Delivery of siRNA to the Central Nervous System . . . . . . . . . . . . 251' n- o3 ]3 C' I8 B% [2 ~$ E  D! ~
Mark D. Zabel
5 e9 a3 G* O) ^% ~( I: y. a18 Flow Cytometry-Based Cell Type-Speci fi c Assessment of Target Regulation/ K/ H4 }7 m9 z- H! P/ \' C7 [
by Pulmonary siRNA Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263
9 z7 i$ E) x! ?- S" COlivia M. Merkel, Leigh M. Marsh, Holger Garn, and Thomas Kissel& r1 M) N  g8 X0 Y9 W' _: ?
19 Liver-Targeted Gene Delivery Through Retrograde Intrabiliary Infusion. . . . . 275
/ O- z* v* e: Q0 eXuan Jiang, Yong Ren, John-Michael Williford, Zhiping Li,- r0 w' W8 s) x! ^) T
and Hai-Quan Mao2 U# g' D6 ?- W( K' z
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2852 j$ ]5 e) t8 X- f  d' v" Q" l

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