Nature Reprogramming review

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http://www.ncbi.nlm.nih.gov/pubmed/23498940?dopt=Abstract
0 g3 Z! K; J6 c9 V4 CEpigenetics of Reprogramming to Induced Pluripotency.
9 {* T' d' W8 d! ^Papp B, Plath K.
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Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Bioinformatics Interdepartmental Degree Program, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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Abstract/ y  J& V% ]9 G
Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner with reprogramming factor binding, transcription, and chromatin states changing during transitions. Evidence is emerging that epigenetic priming events early in the process may be critical for pluripotency induction later. Chromatin and its regulators are important controllers of reprogramming, and reprogramming factor levels, stoichiometry, and extracellular conditions influence the outcome. The rapid progress in characterizing reprogramming is benefiting applications of iPSCs and is already enabling the rational design of novel reprogramming factor cocktails. However, recent studies have also uncovered an epigenetic instability of the X chromosome in human iPSCs that warrants careful consideration.& v% ~( U% w; R. K8 p/ ]
Copyright © 2013 Elsevier Inc. All rights reserved.
: F- j) y. u: d: y8 i/ NPMID: 23498940 [PubMed - as supplied by publisher]