Nature Reprogramming review

刘志红

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The emerging conceptual framework of evolutionary developmental biology
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Jonathan

回复 刘志红 的帖子
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拜托，以后看看再发上来。那个是2002年了。里面很多东西估计已经被别人所证实或者反驳了。以后这些review的文章，最好找新一点的啊。你找个十几年前的来，是想来赚点包包么？

Jonathan

回复 刘志红 的帖子9 r. A3 g0 y7 E, I" `& Q

# \1 O: v( R% k! m. s拜托，以后看看再发上来。那个是2002年了。里面很多东西估计已经被别人所证实或者反驳了。以后这些review的文章，最好找新一点的啊。你找个十几年前的来，是想来赚点包包么？

Jonathan

回复 刘志红 的帖子
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拜托，以后看看再发上来。那个是2002年了。里面很多东西估计已经被别人所证实或者反驳了。以后这些review的文章，最好找新一点的啊。你找个十几年前的来，是想来赚点包包么？

flywithiyiy

学习

gact

http://www.ncbi.nlm.nih.gov/pubmed/23498940?dopt=Abstract
7 \# q! A! x* o) nEpigenetics of Reprogramming to Induced Pluripotency." ^# f$ \3 L2 q8 L7 [
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Source
- b, b% J; b9 f6 j+ ~Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Bioinformatics Interdepartmental Degree Program, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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  j% C" ^; k- lAbstract
! n6 t4 [' h& S  G8 aReprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner with reprogramming factor binding, transcription, and chromatin states changing during transitions. Evidence is emerging that epigenetic priming events early in the process may be critical for pluripotency induction later. Chromatin and its regulators are important controllers of reprogramming, and reprogramming factor levels, stoichiometry, and extracellular conditions influence the outcome. The rapid progress in characterizing reprogramming is benefiting applications of iPSCs and is already enabling the rational design of novel reprogramming factor cocktails. However, recent studies have also uncovered an epigenetic instability of the X chromosome in human iPSCs that warrants careful consideration.7 z' B6 p+ ]7 R0 g
Copyright © 2013 Elsevier Inc. All rights reserved.
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刘志红

回复 Jonathan 的帖子
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你这话很是让人不爽，啥叫 为了赚点包包啊？做研究就是不断地提出新的看法，推翻不对的观点的过程，没有什么是永远对的，我们只是为了学习做研究的思路而已。一味的追求新，难怪永远都赶不上人家外国人呢。

Jonathan

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好吧。大哥。我浪费了我的包包而已。您继续

pingzongyunlan

感谢LZ~

pingzongyunlan

下面的原文~