2013-6-27 Immunity

nero1981

- a4 }9 w" u  s  E
Volume 38, Issue 6' m- {) @  R* l# ~
On the cover: Satoh et al. (1105–1115) demonstrate that a genome organizer, ( v( j" W# P6 |' l+ |: o2 t
special AT-rich sequence binding protein 1 (Satb1), is important in 0 W* L0 I$ F7 l, M4 X# \) {8 x. D; ]
lymphoid-lineage specification of hematopoietic stem cells (HSCs). The cover & x/ d* r& t! J0 N& M+ ?1 s
image shows that the attenuation of Satb1 expression in aged HSCs results in / |; I4 `$ c! B, v' A, o
reduced lymphopoietic potential, which is one of the manifestations of 0 \) \% ]0 m- p' z
“immunosenescence.” Their findings suggest that Satb1 expression is a useful
) g& V" Q8 l9 }2 f& M" Fbiomarker of aging and could be manipulated to reverse immunosenescence. “M,” 2 C8 r( k$ h1 P9 x* k. c! M7 u' O
“E,” and “L” indicate “myeloid-,” “erythroid-,” and “lymphoid-fate decisions,” . I' ~% c6 f+ J4 s" D7 ]! i
respectively. Image by Yusuke Satoh and Yusuke Koshima.# v, g) w: ]& o

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