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/ a' o; _ M' {% hVolume 38, Issue 6
* ]7 o7 d! d5 o% O7 \On the cover: Satoh et al. (1105–1115) demonstrate that a genome organizer, 6 _7 H6 U# Q2 {3 @
special AT-rich sequence binding protein 1 (Satb1), is important in % ~! u; v" Z3 H! `5 i
lymphoid-lineage specification of hematopoietic stem cells (HSCs). The cover ; U8 u% O4 D& [5 \
image shows that the attenuation of Satb1 expression in aged HSCs results in 6 C6 V3 _& s: a9 w* A) R5 q
reduced lymphopoietic potential, which is one of the manifestations of ( h5 ^4 e7 l9 X' S0 c2 S8 F6 }
“immunosenescence.” Their findings suggest that Satb1 expression is a useful
$ E; P, ?( Z. m5 ~3 g1 ], Ubiomarker of aging and could be manipulated to reverse immunosenescence. “M,”
5 i- \8 G- L/ V7 H, j“E,” and “L” indicate “myeloid-,” “erythroid-,” and “lymphoid-fate decisions,” 2 \9 e' f @: x7 g4 d3 b' j
respectively. Image by Yusuke Satoh and Yusuke Koshima.; Z l- p" O7 _1 |# B
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发表于 2013-6-28 22:55
发表于 2013-6-29 07:47
