北京大学生命科学学院新任院长：吴虹 - 干细胞行业新闻干细胞之家



免疫细胞治疗专区	欢迎关注干细胞微信公众号

返回列表

查看: 37456\|回复: 7	go 北京大学生命科学学院新任院长：吴虹 [复制链接]

yinfuhua

版主

Rank: 7 Rank: 7 Rank: 7

积分: 24651
威望: 24651
包包: 140622

优秀版主博览群书美女研究员优秀会员

楼主

发表于 2013-9-3 20:10 |只看该作者 |正序浏览 |打印

北京大学生命科学学院新任院长：吴虹% @" W* `6 {0 |
2013-09-03 来源：生物360 作者：koo
) \" ~% y1 ~) a) Q  U, K
吴虹，博士。美国加州大学洛杉矶分校分子和医学药理学系教授。美国加州大学洛杉矶分校分子遗传技术中心主任。JCCC癌症干细胞研究项目联合副主任。JCCC泌尿生殖系统肿瘤项目成员，信号转导研究及治疗项目成员，加州大学洛杉矶分校脑研究所成员。2 P$ D% B: f: m) [3 t- R
主要研究方向为肿瘤细胞信号转导及分子机制研究，曾以第一作者和通讯作者在Nature、Cell、Blood和PNAS等顶级学术期刊发表多篇有重要影响力的论文。 2011年被选为美国科学促进协会院士。
在北大医学院取得学士学位后，留学美国。在哈佛大学取得生物化学博士学位，麻省理工学院白头研究所博士后。其在UCLA的实验室主要进行肿瘤细胞信号转导及分子机制研究。
2013年9月3日，正式接替饶毅，担任新一任北京大学生命科学学院院长。
了解更多：% z/ [% Y( x( G/ U  N! C1 m! x
Welcome to the Hong Wu's Lab! - UCLA
代表论文：
Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.; U- J0 ]1 ?  g' q* q) q+ X
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.
Xu, X. Kobayashi, S. Qiao, W. Li, C. Xiao, C. Radaeva, S. Stiles, B. Wang, R. H. Ohara, N. Yoshino, T. LeRoith, D. Torbenson, M. S. Gores, G. J. Wu, H. Gao, B. Deng, C. X. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006; 116(7): 1843-52.
Wu, H. Khodavirdi, A Roy-Burman, P. Capturing signal anomalies of human prostate cancer into mouse models. Prostate cancer: basic mechanisms and therapeutic approaches 2005; in press.9 ?7 Y2 K$ R# S. [
Kurlawalla-Martinez, C. Stiles, B. Wang, Y. Devaskar, S. U. Kahn, B. B. Wu, H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.7 R9 [7 y( r" l4 K( T
Lasky, J. and Wu, H. Notch signaling pathways, brain development and human disease. Pediatric Research 2005; in press.2 {  i* Q+ S1 ]/ l9 x7 S
Yue, Q. Groszer, M. Gil, J. S. Berk, A. J. Messing, A. Wu, H. Liu, X. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development. 2005; 132(14): 3281-91.# X* {+ O" f8 j4 h
Stanger, B. Z. Stiles, B. Lauwers, G. Y. Bardeesy, N. Mendoza, M. Wang, Y. Greenwood, A. Cheng, K. H. McLaughlin, M. Brown, D. Depinho, R. A. Wu, H. Melton, D. A. Dor, Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95.
Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.
Lasky J, and Wu H Notch signaling pathways, brain development and human disease.Pediatric Research 2005; in press.3 |: j: F' y2 B, n: D. Q
Liu B, Yang R, Wong KA, Getman C, Stein N, Cheng G, Wu H, and Shuai K PIAS1 Participates in the Negative Regulation of NF-kB Signaling. Mol. Cell Biol. 2005; 25: 1113-23." @5 R+ q) Z/ f, _, }
Mulholland DJ, Dedhar S, Wu H and Nelson CC PTEN & GSK3?O: Key Regulators of Progression to Androgen Independent Prostate Cancer. . Oncogene 2005; in press.3 y# K/ N0 ^' \0 L( S1 v$ f
Sanchez T, Thangada S, Wu MT, Kontos C, Wu D, Wu H And Hla T PTEN as an effector in the signaling of anti-migratory G protein-coupled receptor. Proc. Natl. Acad. Sci. USA 2005; 102: 4312-7., j! u# f) n* A, G- {0 v! E5 y4 V3 d
Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization.Development. 2005; 132(14): 3281-91." p1 }6 {2 L8 s: e, }& M+ Y+ k
Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95.
Roy-Burman, P. Wu, H. Powell, W. C. Hagenkord, J. Cohen, M. B. Genetically defined mouse models that mimic natural aspects of human prostate cancer development.Endocr Relat Cancer. 2004; 11(2): 225-54.# Q8 `+ u$ @8 W$ E. f4 s
Sundaresan, G. Paulmurugan, R. Berger, F. Stiles, B. Nagayama, Y. Wu, H. Gambhir, S. S. MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18./ ~0 ~1 s, f) t1 X" P
Liu, B. Mink, S. Wong, K. A. Stein, N. Getman, C. Dempsey, P. W. Wu, H. Shuai, K. PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.
Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004; 24(12): 5577-86.
Roy-Burman P, Wu H, Powell WC, Hagenkord J, Cohen MB Genetically defined mouse models that mimic natural aspects of human prostate cancer development. Endocr Relat Cancer. 2004; 11(2): 225-54.5 k; e) r3 Q3 f0 @9 y  u0 k" U
Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18.4 ?- M( {4 _5 L/ u" y, B
Liu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.- C. p4 |& ?1 n. I/ c9 {! z. U3 i
Wong, K. A. Tsai, P. T. Jegalian, A. Kertesz, N. Lee, R. Wu, H. Erythropoietin, biochemistry of.. Encyclopedia of hormones 2003; 561-569.
Freeman, D. J. Li, A. G. Wei, G. Li, H. H. Kertesz, N. Lesche, R. Whale, A. D. Martinez-Diaz, H. Rozengurt, N. Cardiff, R. D. Liu, X. Wu, H. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003; 3(2): 117-30.- z: ^; N2 g' k* w  q% O2 d5 [3 @
Wang, S. Gao, J. Lei, Q. Rozengurt, N. Pritchard, C. Jiao, J. Thomas, G. V. Li, G. Roy-Burman, P. Nelson, P. S. Liu, X. Wu, H. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.
Anzelon, A. N. Wu, H. Rickert, R. C. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol. 2003; 4(3): 287-94.
Wong K, Tsai P, Jegalian A, Kertesz N, Lee R and Wu H Erythropoietin, Biochemistry of.. In Encyclopedia of Hormones. 2003; 561-569..
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.Cancer Cell. 2003; 3(2): 117-30.9 r$ \, ?- Q4 C  G; T" o% O+ D" s
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.
Li, G. Robinson, G. W. Lesche, R. Martinez-Diaz, H. Jiang, Z. Rozengurt, N. Wagner, K. U. Wu, D. C. Lane, T. F. Liu, X. Hennighausen, L. Wu, H. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.Development. 2002; 129(17): 4159-70.
Lesche, R. Groszer, M. Gao, J. Wang, Y. Messing, A. Sun, H. Liu, X. Wu, H.Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis.2002; 32(2): 148-9.
Jegalian, A. G. Wu, H. Differential roles of SOCS family members in EpoR signal transduction. J Interferon Cytokine Res. 2002; 22(8): 853-60.8 D. X$ w, D% y% e& [( T5 f* N( S/ D
Stiles, B. Gilman, V. Khanzenzon, N. Lesche, R. Li, A. Qiao, R. Liu, X. Wu, H. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.Mol Cell Biol. 2002; 22(11): 3842-51.
Jegalian A and Wu H Differential Regulation of SOCS Gene Expression and Distinct Roles of SOCS family Members in Erythropoietin Receptor Signal Transduction.. J. Cyto.Research . 2002; 22: 3842-3851.
Jegalian, A., Acurio, A., Dranoff, G., Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukine 3.. Blood . 2002; 99: 2603-2605.3 V' _/ g/ k3 @+ a/ X* \
Makita T, Hernandez-Hoyos G, Chen T, Wu H, Rothenberg E and Sucov H A Developmental Transition in Definitive Erythropoiesis Controlled by Competitive Regulation of Erythropoietin Expression by Retinoid Acid Receptor and HNF4.. Gene & Devel.. 2001; 15: 889-901., r' b% T& L7 I) x* ~; g2 @
Neshat M, Mellinghoff I, Tran C, Stiles B, Thomas G, Wu H, and Sawyers C Enhanced sensitively of PTEN-Deficient Tumors to Inhibition of FRAP/mTOR.. Proc. Natl. Acad. Sci. USA. . 2001; 98: 10314-1031.
Hisakawa H, Sugiyama D, Nishijima I, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K Human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF) Stimulates Primitive and Definitive Erythropoiesis in Mouse Embryo Expressing hGM-CSF Receptors but not Erythropoietin Receptors.. Blood . 2001; 98: 3618-3625.
Mamillapalli R, Gavrilova N, Mihaylova V, Tsvetkov L, Wu H, Zhang H and Sun H PTEN Regulates The Ubiquitin-Dependent Degradation Of The Cdk Inhibitor P27kip1 Through The Ubiquitin E3 Ligase Scfskp2.. Current Biology . 2001; 11: 263-267.
Wu, H. Lee, S. H. Gao, J. Liu, X. Iruela-Arispe, M. L. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development. 1999; 126(16): 3597-605.  u% r8 C4 L  M
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Garvarina N, Mueller B, Liu X and Wu H PTEN Modulates Cell Cycle Prograssion and Cell Survival by Regulating PIP3 and AKT/PKB Signaling Pathway.. Proc. Natl. Acad. Sci.. 1999; 96: 6199-6204.0 R7 e8 D2 m7 n( [+ b! ^# N
Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U and Pfeffer K Jak2 Deficiency Defines an Essential Developmental Checkpoint in Definitive Hematopoiesis.. Cell. 1998; 93: 397-409.. N+ z% T: s. K+ m/ w( u/ v
Liu, X. Wu, H. Loring, J. Hormuzdi, S. Disteche, C. M. Bornstein, P. Jaenisch, R. Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.
Wu H, Klingmuller U, Acurio A, Hsiao JG and Lodish HF Functional Interaction of Erythropoietin and Stem Cell Factor Receptors is Essential for Erythroid Colony Formation.. Proc. Natl. Acad. Sci. USA. . 1997; 94: 1806-1810.
Klingmuller K, Wu H, Hsiao J, Duckworth B, Toker A, Cantley LC and Lodish HF Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.. Proc. Natl. Acad. Sci. USA . 1997; 94: 3016-3021.4 J' G) O  s; H9 ?0 _0 l" s
Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.
Watowich, S. S. Wu, H. Socolovsky, M. Klingmuller, U. Constantinescu, S. N. Lodish, H. F. Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 1996; 12: 91-128.. @  h# E* a8 J: G2 l: z3 }
Wu, H. and Lodish, H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.
Iruela-Arispe, M. L. Vernon, R. B. Wu, H. Jaenisch, R. Sage, E. H. Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Dev Dyn. 1996; 207(2): 171-83.
Wu H and Lodish H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.
Iruela ML, Vernon RB, Wu H, Jeanisch R and Sage H Type I collagen is required for the association of SPARC with the extracellular matrix in Mov-13 mice: implications for fibroblast function.. Developmental Dynamics . 1996; 207: 171-183.
Liu, X. Wu, H. Byrne, M. Jeffrey, J. Krane, S. Jaenisch, R. A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol. 1995; 130(1): 227-37.! {1 p& I( f  n
Lodish, H. F. Hilton, D. J. Klingmuller, U. Watowich, S. S. Wu, H. The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harb Symp Quant Biol. 1995; 60: 93-104.  k- H; T; K  h8 w
Dzamba, B. J. Wu, H. Jaenisch, R. Peters, D. M. Fibronectin binding site in type I collagen regulates fibronectin fibril formation. J Cell Biol. 1993; 121(5): 1165-72.5 O5 U: B% [& k& _4 ]- t
Hasty, K. A. Wu, H. Byrne, M. Goldring, M. B. Seyer, J. M. Jaenisch, R. Krane, S. M. Mainardi, C. L. Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase. Matrix. 1993; 13(3): 181-6.
Wu, H. Fassler, R. Schnieke, A. Barker, D. Lee, K. H. Chapman, V. Francke, U. Jaenisch, R. An X-linked human collagen transgene escapes X inactivation in a subset of cells. Development. 1992; 116(3): 687-95.$ S7 l5 z; R( \8 B  m3 M$ B
Barker, D. D. Wu, H. Hartung, S. Breindl, M. Jaenisch, R. Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice. Mol Cell Biol. 1991; 11(10): 5154-63.
Wu, H. Byrne, M. H. Stacey, A. Goldring, M. B. Birkhead, J. R. Jaenisch, R. Krane, S. M. Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc Natl Acad Sci U S A. 1990; 87(15): 5888-92.( ~1 D4 ?# Y/ s
Horvath, S. Zhang, B. Carlson, M. Lu, K. V. Zhu, S. Felciano, R. M. Laurance, M. F. Zhao, W. Qi, S. Chen, Z. Lee, Y. Scheck, A. C. Liau, L. M. Wu, H. Geschwind, D. H. Febbo, P. G. Kornblum, H. I. Cloughesy, T. F. Nelson, S. F. Mischel, P. S. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A. 2006; 103(46): 17402-7.) }& n9 d4 j2 [- F
Huang, W. Chang, H. Y. Fei, T. Wu, H. Chen, Y. G. GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene. 2006; .6 B3 d! ?) N- u# ~7 q
Freeman, D. Lesche, R. Kertesz, N. Wang, S. Li, G. Gao, J. Groszer, M. Martinez-Diaz, H. Rozengurt, N. Thomas, G. Liu, X. Wu, H. Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006; 66(13): 6492-6.
Zhang, J. Grindley, J. C. Yin, T. Jayasinghe, S. He, X. C. Ross, J. T. Haug, J. S. Rupp, D. Porter-Westpfahl, K. S. Wiedemann, L. M. Wu, H. Li, L. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.Nature. 2006; 441(7092): 518-22." P! Y6 M& D( g) f# ]1 y2 `
Yilmaz, O. H. Valdez, R. Theisen, B. K. Guo, W. Ferguson, D. O. Wu, H. Morrison, S. J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006; 441(7092): 475-82.
Li, G. Hu, Y. Huo, Y. Liu, M. Freeman, D. Gao, J. Liu, X. Wu, D. Wu, H. PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. J Biol Chem. 2006; .$ q8 }  Y4 K; y# `. H. |2 I
Yoo, L. I. Liu, D. W. Le Vu, S. Bronson, R. T. Wu, H. Yuan, J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner.Cancer Res. 2006; 66(4): 1929-39.
Yao, D. Alexander, C. L. Quinn, J. A. Porter, M. J. Wu, H. Greenhalgh, D. A. PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways. Cancer Res. 2006; 66(3): 1302-12.' [2 I9 O- Y  b) Q6 A  v( z8 c
Wang, S. Garcia, A. J. Wu, M. Lawson, D. A. Witte, O. N. Wu, H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.4 c& H6 K) G1 G! V( w- L' j
Tsai, P. T. Ohab, J. J. Kertesz, N. Groszer, M. Matter, C. Gao, J. Liu, X. Wu, H. Carmichael, S. T. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.5 Y* n8 s( d" Z5 _" g
Mulholland, D. J. Dedhar, S. Wu, H. Nelson, C. C. PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene. 2006; 25(3): 329-37.; @+ s) v# W( c: ~4 A
Khodavirdi, A. C. Song, Z. Yang, S. Zhong, C. Wang, S. Wu, H. Pritchard, C. Nelson, P. S. Roy-Burman, P. Increased expression of osteopontin contributes to the progression of prostate cancer. Cancer Res. 2006; 66(2): 883-8.
Groszer, M. Erickson, R. Scripture-Adams, D. D. Dougherty, J. D. Le Belle, J. Zack, J. A. Geschwind, D. H. Liu, X. Kornblum, H. I. Wu, H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
Berquin, I. M. Min, Y. Wu, R. Wu, H. Chen, Y. Q. Expression signature of the mouse prostate. J Biol Chem. 2005; 280(43): 36442-51.% r5 E% v9 m0 l$ t6 Z& {
Nakano, I. Paucar, A. A. Bajpai, R. Dougherty, J. D. Zewail, A. Kelly, T. K. Kim, K. J. Ou, J. Groszer, M. Imura, T. Freije, W. A. Nelson, S. F. Sofroniew, M. V. Wu, H. Liu, X. Terskikh, A. V. Geschwind, D. H. Kornblum, H. I. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.J Cell Biol. 2005; 170(3): 413-27.4 w, H1 ^3 Q. C; w8 v
Shi, Y. Sharma, A. Wu, H. Lichtenstein, A. Gera, J. Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. J Biol Chem. 2005; 280(12): 10964-73.5 b- Y5 S! I' C! Q5 S
Sanchez, T. Thangada, S. Wu, M. T. Kontos, C. D. Wu, D. Wu, H. Hla, T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005; 102(12): 4312-7.
Lim, M. A. Yang, L. Zheng, Y. Wu, H. Dong, L. Q. Liu, F. Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells.Oncogene. 2004; 23(58): 9348-58.
Kertesz, N. Wu, J. Chen, T. H. Sucov, H. M. Wu, H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004; 276(1): 101-10.
Stiles, B. Groszer, M. Wang, S. Jiao, J. Wu, H. PTENless means more. Dev Biol. 2004; 273(2): 175-84.; \4 e, ~" Y( D6 @: j4 @( W. K& B
Chang, C. J. Freeman, D. J. Wu, H. PTEN regulates Mdm2 expression through the P1 promoter. J Biol Chem. 2004; 279(28): 29841-8.9 M3 e' Z( g* H& M
Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.. The Journal of biological chemistry. . 2004; 279(23): 24794-802.
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004; 101(7): 2082-7.
Tsai, P. T. Lee, R. A. Wu, H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Blood. 2003; 102(12): 3947-53.
Anzelon AN, Wu H, Rickert RC Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.. Nature immunology. . 2003; 4(3): 287-94.
Osawa, M. Yamaguchi, T. Nakamura, Y. Kaneko, S. Onodera, M. Sawada, K. Jegalian, A.Wu, H. Nakauchi, H. Iwama, A. Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood. 2002; 100(8): 2769-77.
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.. Development (Cambridge, England) . 2002; 129(17): 4159-70.3 V" D- ]6 N& y. x/ z# |
Kertesz, N. Samson, J. Debacker, C. Wu, H. Labastie, M. C. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene. 2002; 294(1-2): 13-24.! S1 D! I0 R* D
Jegalian, A. G. Acurio, A. Dranoff, G. Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3. Blood. 2002; 99(7): 2603-5.; t# T0 U5 F0 @6 \! q* O( z
Jegalian, AG Wu, H Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.. The Journal of biological chemistry. . 2002; 277(3): 2345-52.
Hisakawa, H. Sugiyama, D. Nishijima, I. Xu, M. J. Wu, H. Nakao, K. Watanabe, S. Katsuki, M. Asano, S. Arai, K. Nakahata, T. Tsuji, K. Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. Blood. 2001; 98(13): 3618-25.
Groszer, M. Erickson, R. Scripture-Adams, D. D. Lesche, R. Trumpp, A. Zack, J. A. Kornblum, H. I. Liu, X. Wu, H. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. 2001; 294(5549): 2186-9.
Lee, R. Kertesz, N. Joseph, S. B. Jegalian, A. Wu, H. Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001; 98(5): 1408-15.8 D* U+ I. q  }# ?; V
Neshat, M. S. Mellinghoff, I. K. Tran, C. Stiles, B. Thomas, G. Petersen, R. Frost, P. Gibbons, J. J. Wu, H. Sawyers, C. L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001; 98(18): 10314-9.
Dubey, P. Wu, H. Reiter, R. E. Witte, O. N. Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. Cancer Res. 2001; 61(8): 3256-61.! K" A9 P' D3 N+ X
Makita, T. Hernandez-Hoyos, G. Chen, T. H. Wu, H. Rothenberg, E. V. Sucov, H. M. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev. 2001; 15(7): 889-901.
Mamillapalli, R. Gavrilova, N. Mihaylova, V. T. Tsvetkov, L. M. Wu, H. Zhang, H. Sun, H. PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol. 2001; 11(4): 263-7.. N: R0 d+ |0 q$ m9 {) h6 k
Satterthwaite, A. B. Willis, F. Kanchanastit, P. Fruman, D. Cantley, L. C. Helgason, C. D. Humphries, R. K. Lowell, C. A. Simon, M. Leitges, M. Tarakhovsky, A. Tedder, T. F. Lesche, R. Wu, H. Witte, O. N. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000; 97(12): 6687-92.$ w% u7 o- i: M
Liliental, J. Moon, S. Y. Lesche, R. Mamillapalli, R. Li, D. Zheng, Y. Sun, H. Wu, H. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000; 10(7): 401-4.7 m$ u9 S4 j4 \. R2 w! B1 p' w
Ghaffari, S. Wu, H. Gerlach, M. Han, Y. Lodish, H. F. Daley, G. Q. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc Natl Acad Sci U S A. 1999; 96(23): 13186-90.8 R7 k. U  \4 ~' B- z
Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML Inactivation of erythropoietin leads to defects in cardiac morphogenesis.. Development (Cambridge, England) . 1999; 126(16): 3597-605., }3 c/ _# R7 O6 s- {, L" a
Sun, H. Lesche, R. Li, D. M. Liliental, J. Zhang, H. Gao, J. Gavrilova, N. Mueller, B. Liu, X. Wu, H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A. 1999; 96(11): 6199-204.  B2 q  {2 \( s" X
Neubauer, H. Cumano, A. Muller, M. Wu, H. Huffstadt, U. Pfeffer, K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998; 93(3): 397-409.
Constantinescu, S. N. Wu, H. Liu, X. Beyer, W. Fallon, A. Lodish, H. F. The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid. Blood. 1998; 91(4): 1163-72.2 u1 @' x  A7 r( W0 ?# [  r
Klingmuller, U. Wu, H. Hsiao, J. G. Toker, A. Duckworth, B. C. Cantley, L. C. Lodish, H. F. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A. 1997; 94(7): 3016-21.! W1 }% q4 _' T- B. o/ z0 C
Wu, H. Klingmuller, U. Acurio, A. Hsiao, J. G. Lodish, H. F. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci U S A. 1997; 94(5): 1806-10.
Liu, X. Wu, H. Byrne, M. Krane, S. Jaenisch, R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997; 94(5): 1852-6.
Krane, S. M. Byrne, M. H. Lemaitre, V. Henriet, P. Jeffrey, J. J. Witter, J. P. Liu, X. Wu, H. Jaenisch, R. Eeckhout, Y. Different collagenase gene products have different roles in degradation of type I collagen. J Biol Chem. 1996; 271(45): 28509-15.
Wu, H. Liu, X. Jaenisch, R. Lodish, H. F. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995; 83(1): 59-67.
Wu, H. Klingmuller, U. Besmer, P. Lodish, H. F. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 1995; 377(6546): 242-6.
Wu, H. Liu, X. Jaenisch, R. Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A. 1994; 91(7): 2819-23.+ V% H2 F6 D) t5 o: N$ W
Barker DD, Wu H, Hartung S, Breindl M, Jaenisch R Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.. Molecular and cellular biology. . 1991; 11(10): 5154-63.9 ~0 L9 K1 z7 |6 Q
Silverman, D. H. Wu, H. Karnovsky, M. L. Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide release. Biochem Biophys Res Commun. 1985; 131(3): 1160-7.

附件: 你需要登录才可以下载或查看附件。没有帐号？注册