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北京大学生命科学学院新任院长：吴虹0 z5 E# s2 I0 o/ R* p+ L$ a/ d
2013-09-03 来源：生物360 作者：koo
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, S2 m6 v4 r$ P( ^7 \( U3 c7 X. m吴虹，博士。美国加州大学洛杉矶分校分子和医学药理学系教授。美国加州大学洛杉矶分校分子遗传技术中心主任。JCCC癌症干细胞研究项目联合副主任。JCCC泌尿生殖系统肿瘤项目成员，信号转导研究及治疗项目成员，加州大学洛杉矶分校脑研究所成员。# m" s' i4 F$ m$ k# i$ f
主要研究方向为肿瘤细胞信号转导及分子机制研究，曾以第一作者和通讯作者在Nature、Cell、Blood和PNAS等顶级学术期刊发表多篇有重要影响力的论文。 2011年被选为美国科学促进协会院士。
% p( l+ P' D9 i' R4 I/ L在北大医学院取得学士学位后，留学美国。在哈佛大学取得生物化学博士学位，麻省理工学院白头研究所博士后。其在UCLA的实验室主要进行肿瘤细胞信号转导及分子机制研究。
/ ^0 b7 R G% F2013年9月3日，正式接替饶毅，担任新一任北京大学生命科学学院院长。
6 h I$ F( {) P. z& U* i! s了解更多：; x N N1 K [* G' R- F
Welcome to the Hong Wu's Lab! - UCLA9 i3 Y3 L% g5 r! l: a0 F
代表论文：
9 K1 ~3 N# k. v7 Y" \Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74./ R1 j! s% ~1 T7 l7 e; g! j2 E+ v
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
0 N. g: T# T9 E0 A' _Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.0 Z! x/ P. N% M/ }. \& m
Xu, X. Kobayashi, S. Qiao, W. Li, C. Xiao, C. Radaeva, S. Stiles, B. Wang, R. H. Ohara, N. Yoshino, T. LeRoith, D. Torbenson, M. S. Gores, G. J. Wu, H. Gao, B. Deng, C. X. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006; 116(7): 1843-52.
1 M2 f/ u$ }% b/ \3 M- o: K( N% gWu, H. Khodavirdi, A Roy-Burman, P. Capturing signal anomalies of human prostate cancer into mouse models. Prostate cancer: basic mechanisms and therapeutic approaches 2005; in press.- v( K% b+ d1 {6 |3 n% [" P; c
Kurlawalla-Martinez, C. Stiles, B. Wang, Y. Devaskar, S. U. Kahn, B. B. Wu, H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.
/ s; i/ ]2 S$ ]Lasky, J. and Wu, H. Notch signaling pathways, brain development and human disease. Pediatric Research 2005; in press.; n+ Q5 }( p5 b4 i( f% i
Yue, Q. Groszer, M. Gil, J. S. Berk, A. J. Messing, A. Wu, H. Liu, X. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development. 2005; 132(14): 3281-91.
3 k6 w& r' L1 jStanger, B. Z. Stiles, B. Lauwers, G. Y. Bardeesy, N. Mendoza, M. Wang, Y. Greenwood, A. Cheng, K. H. McLaughlin, M. Brown, D. Depinho, R. A. Wu, H. Melton, D. A. Dor, Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95.( W7 ^! e2 X9 \% m$ [
Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.- y$ j) _; f+ L) H! | u+ v( x
Lasky J, and Wu H Notch signaling pathways, brain development and human disease.Pediatric Research 2005; in press./ e2 O+ l3 |0 E* C* c8 \ q
Liu B, Yang R, Wong KA, Getman C, Stein N, Cheng G, Wu H, and Shuai K PIAS1 Participates in the Negative Regulation of NF-kB Signaling. Mol. Cell Biol. 2005; 25: 1113-23.- R# `) o: @6 n. o
Mulholland DJ, Dedhar S, Wu H and Nelson CC PTEN & GSK3?O: Key Regulators of Progression to Androgen Independent Prostate Cancer. . Oncogene 2005; in press.. \# _; _4 Z5 K% E8 w Y
Sanchez T, Thangada S, Wu MT, Kontos C, Wu D, Wu H And Hla T PTEN as an effector in the signaling of anti-migratory G protein-coupled receptor. Proc. Natl. Acad. Sci. USA 2005; 102: 4312-7.
. U* c3 `8 I6 k$ `# \Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization.Development. 2005; 132(14): 3281-91.
9 @+ R" E8 I& p; `' \' @Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95.
9 n0 }* N( C1 S. ~) Y# s; rRoy-Burman, P. Wu, H. Powell, W. C. Hagenkord, J. Cohen, M. B. Genetically defined mouse models that mimic natural aspects of human prostate cancer development.Endocr Relat Cancer. 2004; 11(2): 225-54.6 y# P" D( \) Q
Sundaresan, G. Paulmurugan, R. Berger, F. Stiles, B. Nagayama, Y. Wu, H. Gambhir, S. S. MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18.( Z1 q8 L( O5 u7 D4 {6 H
Liu, B. Mink, S. Wong, K. A. Stein, N. Getman, C. Dempsey, P. W. Wu, H. Shuai, K. PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8./ Q. s, ?, c1 _/ s4 G
Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004; 24(12): 5577-86.
& P6 q, _/ i& }9 |& }2 V5 TRoy-Burman P, Wu H, Powell WC, Hagenkord J, Cohen MB Genetically defined mouse models that mimic natural aspects of human prostate cancer development. Endocr Relat Cancer. 2004; 11(2): 225-54.7 n" q9 R# X# e) g
Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18.
) p' X) Q0 r; n& l) BLiu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.6 m6 J5 N w5 q; f% k; W! e
Wong, K. A. Tsai, P. T. Jegalian, A. Kertesz, N. Lee, R. Wu, H. Erythropoietin, biochemistry of.. Encyclopedia of hormones 2003; 561-569.6 U1 H U* R5 a, x( Z# r
Freeman, D. J. Li, A. G. Wei, G. Li, H. H. Kertesz, N. Lesche, R. Whale, A. D. Martinez-Diaz, H. Rozengurt, N. Cardiff, R. D. Liu, X. Wu, H. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003; 3(2): 117-30.( z& T! I/ O8 y6 v4 V2 c
Wang, S. Gao, J. Lei, Q. Rozengurt, N. Pritchard, C. Jiao, J. Thomas, G. V. Li, G. Roy-Burman, P. Nelson, P. S. Liu, X. Wu, H. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.
2 q# S. L3 w$ k. x1 wAnzelon, A. N. Wu, H. Rickert, R. C. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol. 2003; 4(3): 287-94.# x' N7 u! Y" w) L4 b" L9 ^# E
Wong K, Tsai P, Jegalian A, Kertesz N, Lee R and Wu H Erythropoietin, Biochemistry of.. In Encyclopedia of Hormones. 2003; 561-569..* j% q1 ?/ Q) F$ D
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.Cancer Cell. 2003; 3(2): 117-30.
9 O* {& ^. p6 i R" m) |2 sWang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.
' _. i- g8 }" |Li, G. Robinson, G. W. Lesche, R. Martinez-Diaz, H. Jiang, Z. Rozengurt, N. Wagner, K. U. Wu, D. C. Lane, T. F. Liu, X. Hennighausen, L. Wu, H. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.Development. 2002; 129(17): 4159-70.) F5 N" |5 S5 q4 X* j; q `" A- W
Lesche, R. Groszer, M. Gao, J. Wang, Y. Messing, A. Sun, H. Liu, X. Wu, H.Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis.2002; 32(2): 148-9.( R1 ?; s/ h/ A5 z7 B& X0 o
Jegalian, A. G. Wu, H. Differential roles of SOCS family members in EpoR signal transduction. J Interferon Cytokine Res. 2002; 22(8): 853-60.
1 O1 y: o$ T( k: `Stiles, B. Gilman, V. Khanzenzon, N. Lesche, R. Li, A. Qiao, R. Liu, X. Wu, H. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.Mol Cell Biol. 2002; 22(11): 3842-51.
2 `! c- d) V# K3 gJegalian A and Wu H Differential Regulation of SOCS Gene Expression and Distinct Roles of SOCS family Members in Erythropoietin Receptor Signal Transduction.. J. Cyto.Research . 2002; 22: 3842-3851.
5 K+ H6 L' q' ~$ Z- s+ h( O8 yJegalian, A., Acurio, A., Dranoff, G., Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukine 3.. Blood . 2002; 99: 2603-2605.
0 R; Y# n% s# L- aMakita T, Hernandez-Hoyos G, Chen T, Wu H, Rothenberg E and Sucov H A Developmental Transition in Definitive Erythropoiesis Controlled by Competitive Regulation of Erythropoietin Expression by Retinoid Acid Receptor and HNF4.. Gene & Devel.. 2001; 15: 889-901.
8 P/ V7 b/ X- U, ZNeshat M, Mellinghoff I, Tran C, Stiles B, Thomas G, Wu H, and Sawyers C Enhanced sensitively of PTEN-Deficient Tumors to Inhibition of FRAP/mTOR.. Proc. Natl. Acad. Sci. USA. . 2001; 98: 10314-1031.# {; z' Y8 p) [
Hisakawa H, Sugiyama D, Nishijima I, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K Human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF) Stimulates Primitive and Definitive Erythropoiesis in Mouse Embryo Expressing hGM-CSF Receptors but not Erythropoietin Receptors.. Blood . 2001; 98: 3618-3625.
6 @. l* p- e- }+ A2 R5 fMamillapalli R, Gavrilova N, Mihaylova V, Tsvetkov L, Wu H, Zhang H and Sun H PTEN Regulates The Ubiquitin-Dependent Degradation Of The Cdk Inhibitor P27kip1 Through The Ubiquitin E3 Ligase Scfskp2.. Current Biology . 2001; 11: 263-267.% o5 j! N7 Z4 Q- |: I+ w }% J
Wu, H. Lee, S. H. Gao, J. Liu, X. Iruela-Arispe, M. L. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development. 1999; 126(16): 3597-605.7 i" [4 \8 f% p+ ^" ?3 l& v. n
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Garvarina N, Mueller B, Liu X and Wu H PTEN Modulates Cell Cycle Prograssion and Cell Survival by Regulating PIP3 and AKT/PKB Signaling Pathway.. Proc. Natl. Acad. Sci.. 1999; 96: 6199-6204.
0 n, F, B5 C9 ^Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U and Pfeffer K Jak2 Deficiency Defines an Essential Developmental Checkpoint in Definitive Hematopoiesis.. Cell. 1998; 93: 397-409.
$ D0 P0 r3 Y# J7 zLiu, X. Wu, H. Loring, J. Hormuzdi, S. Disteche, C. M. Bornstein, P. Jaenisch, R. Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.' K- u6 N/ E9 u; W- y& a9 `
Wu H, Klingmuller U, Acurio A, Hsiao JG and Lodish HF Functional Interaction of Erythropoietin and Stem Cell Factor Receptors is Essential for Erythroid Colony Formation.. Proc. Natl. Acad. Sci. USA. . 1997; 94: 1806-1810.
4 t3 n7 _/ e4 xKlingmuller K, Wu H, Hsiao J, Duckworth B, Toker A, Cantley LC and Lodish HF Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.. Proc. Natl. Acad. Sci. USA . 1997; 94: 3016-3021.2 S: e8 W' R7 Z# F2 C
Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.
3 x% \$ \1 ]$ U, s$ ]5 ^4 |$ R& CWatowich, S. S. Wu, H. Socolovsky, M. Klingmuller, U. Constantinescu, S. N. Lodish, H. F. Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 1996; 12: 91-128.6 U4 Z; s! U$ F* m! F
Wu, H. and Lodish, H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.0 @/ A8 s1 o' M* k3 ~( E9 u
Iruela-Arispe, M. L. Vernon, R. B. Wu, H. Jaenisch, R. Sage, E. H. Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Dev Dyn. 1996; 207(2): 171-83.
% j7 x, s& t0 _( }5 q1 XWu H and Lodish H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.
% {+ z V1 H* B, X* @! _Iruela ML, Vernon RB, Wu H, Jeanisch R and Sage H Type I collagen is required for the association of SPARC with the extracellular matrix in Mov-13 mice: implications for fibroblast function.. Developmental Dynamics . 1996; 207: 171-183.4 g% i4 Y% h6 V$ E3 s
Liu, X. Wu, H. Byrne, M. Jeffrey, J. Krane, S. Jaenisch, R. A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol. 1995; 130(1): 227-37.
' W7 \+ ^3 p, ELodish, H. F. Hilton, D. J. Klingmuller, U. Watowich, S. S. Wu, H. The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harb Symp Quant Biol. 1995; 60: 93-104.
; o1 G2 N! Z) d. [+ |Dzamba, B. J. Wu, H. Jaenisch, R. Peters, D. M. Fibronectin binding site in type I collagen regulates fibronectin fibril formation. J Cell Biol. 1993; 121(5): 1165-72.
4 G6 S( ^/ j. x, G! Q& qHasty, K. A. Wu, H. Byrne, M. Goldring, M. B. Seyer, J. M. Jaenisch, R. Krane, S. M. Mainardi, C. L. Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase. Matrix. 1993; 13(3): 181-6.0 M, c7 c4 M( O B& J: _
Wu, H. Fassler, R. Schnieke, A. Barker, D. Lee, K. H. Chapman, V. Francke, U. Jaenisch, R. An X-linked human collagen transgene escapes X inactivation in a subset of cells. Development. 1992; 116(3): 687-95.
4 _6 i) c% P: a) ~6 ]9 N, v; zBarker, D. D. Wu, H. Hartung, S. Breindl, M. Jaenisch, R. Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice. Mol Cell Biol. 1991; 11(10): 5154-63.% X( N3 W9 W0 g! E9 n" Y0 z
Wu, H. Byrne, M. H. Stacey, A. Goldring, M. B. Birkhead, J. R. Jaenisch, R. Krane, S. M. Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc Natl Acad Sci U S A. 1990; 87(15): 5888-92.- [% w6 r8 Z$ C! t) R7 F1 }
Horvath, S. Zhang, B. Carlson, M. Lu, K. V. Zhu, S. Felciano, R. M. Laurance, M. F. Zhao, W. Qi, S. Chen, Z. Lee, Y. Scheck, A. C. Liau, L. M. Wu, H. Geschwind, D. H. Febbo, P. G. Kornblum, H. I. Cloughesy, T. F. Nelson, S. F. Mischel, P. S. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A. 2006; 103(46): 17402-7.
3 ^7 v4 Z: `% ]$ Y7 H9 D( I; i2 [Huang, W. Chang, H. Y. Fei, T. Wu, H. Chen, Y. G. GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene. 2006; .
+ I, @" P& u. z" L% nFreeman, D. Lesche, R. Kertesz, N. Wang, S. Li, G. Gao, J. Groszer, M. Martinez-Diaz, H. Rozengurt, N. Thomas, G. Liu, X. Wu, H. Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006; 66(13): 6492-6. z" Q- R2 q4 U' w" c: g
Zhang, J. Grindley, J. C. Yin, T. Jayasinghe, S. He, X. C. Ross, J. T. Haug, J. S. Rupp, D. Porter-Westpfahl, K. S. Wiedemann, L. M. Wu, H. Li, L. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.Nature. 2006; 441(7092): 518-22.2 w& @% v4 B; c
Yilmaz, O. H. Valdez, R. Theisen, B. K. Guo, W. Ferguson, D. O. Wu, H. Morrison, S. J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006; 441(7092): 475-82.
5 r- k+ H+ s& F! b) S, ]% ]% }Li, G. Hu, Y. Huo, Y. Liu, M. Freeman, D. Gao, J. Liu, X. Wu, D. Wu, H. PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. J Biol Chem. 2006; .. n! r5 I6 l7 m+ e, G0 d
Yoo, L. I. Liu, D. W. Le Vu, S. Bronson, R. T. Wu, H. Yuan, J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner.Cancer Res. 2006; 66(4): 1929-39.0 p( _* o3 A1 N/ J7 k8 w
Yao, D. Alexander, C. L. Quinn, J. A. Porter, M. J. Wu, H. Greenhalgh, D. A. PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways. Cancer Res. 2006; 66(3): 1302-12.5 t3 ^7 M1 r+ b. T
Wang, S. Garcia, A. J. Wu, M. Lawson, D. A. Witte, O. N. Wu, H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.
( d0 P* q0 W% X+ c4 fTsai, P. T. Ohab, J. J. Kertesz, N. Groszer, M. Matter, C. Gao, J. Liu, X. Wu, H. Carmichael, S. T. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.
" W" q. C2 }$ Q% h4 bMulholland, D. J. Dedhar, S. Wu, H. Nelson, C. C. PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene. 2006; 25(3): 329-37.
d; K+ X8 X5 ?3 r i, H7 lKhodavirdi, A. C. Song, Z. Yang, S. Zhong, C. Wang, S. Wu, H. Pritchard, C. Nelson, P. S. Roy-Burman, P. Increased expression of osteopontin contributes to the progression of prostate cancer. Cancer Res. 2006; 66(2): 883-8.
& C: h$ K, K9 V1 W* a) s; f3 zGroszer, M. Erickson, R. Scripture-Adams, D. D. Dougherty, J. D. Le Belle, J. Zack, J. A. Geschwind, D. H. Liu, X. Kornblum, H. I. Wu, H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
+ y ~1 W9 r0 P1 W) tBerquin, I. M. Min, Y. Wu, R. Wu, H. Chen, Y. Q. Expression signature of the mouse prostate. J Biol Chem. 2005; 280(43): 36442-51.8 O# T! |5 _+ e8 d4 l
Nakano, I. Paucar, A. A. Bajpai, R. Dougherty, J. D. Zewail, A. Kelly, T. K. Kim, K. J. Ou, J. Groszer, M. Imura, T. Freije, W. A. Nelson, S. F. Sofroniew, M. V. Wu, H. Liu, X. Terskikh, A. V. Geschwind, D. H. Kornblum, H. I. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.J Cell Biol. 2005; 170(3): 413-27.! e8 Z4 U" s( H5 U( U* M
Shi, Y. Sharma, A. Wu, H. Lichtenstein, A. Gera, J. Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. J Biol Chem. 2005; 280(12): 10964-73.
$ {% y6 k; h8 o$ `; d$ gSanchez, T. Thangada, S. Wu, M. T. Kontos, C. D. Wu, D. Wu, H. Hla, T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005; 102(12): 4312-7.7 d2 f7 `2 H$ Y: H& }, A
Lim, M. A. Yang, L. Zheng, Y. Wu, H. Dong, L. Q. Liu, F. Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells.Oncogene. 2004; 23(58): 9348-58.7 W; |( R# t' n9 h$ `
Kertesz, N. Wu, J. Chen, T. H. Sucov, H. M. Wu, H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004; 276(1): 101-10.! e8 B1 g1 m1 J. G3 b8 z
Stiles, B. Groszer, M. Wang, S. Jiao, J. Wu, H. PTENless means more. Dev Biol. 2004; 273(2): 175-84. i# A2 @3 R5 I; B! ?" _+ I
Chang, C. J. Freeman, D. J. Wu, H. PTEN regulates Mdm2 expression through the P1 promoter. J Biol Chem. 2004; 279(28): 29841-8.
2 o" S' O8 d% Z- V- F. H& U, _Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.. The Journal of biological chemistry. . 2004; 279(23): 24794-802.$ y" e1 R2 c- t c5 e/ I
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004; 101(7): 2082-7.
& ]. ` Z, W5 j2 R B) k( u/ P' {& bTsai, P. T. Lee, R. A. Wu, H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Blood. 2003; 102(12): 3947-53.5 c& e* U& V" F8 X4 D: ?; [# g
Anzelon AN, Wu H, Rickert RC Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.. Nature immunology. . 2003; 4(3): 287-94.
# r V( e7 n- Z" u+ ~& e2 A2 gOsawa, M. Yamaguchi, T. Nakamura, Y. Kaneko, S. Onodera, M. Sawada, K. Jegalian, A.Wu, H. Nakauchi, H. Iwama, A. Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood. 2002; 100(8): 2769-77.
" Z5 {, J7 ^' O( H& ZLi G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.. Development (Cambridge, England) . 2002; 129(17): 4159-70.8 r# d5 t7 ]* s2 H6 X
Kertesz, N. Samson, J. Debacker, C. Wu, H. Labastie, M. C. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene. 2002; 294(1-2): 13-24.6 w( [3 {/ _. u* F
Jegalian, A. G. Acurio, A. Dranoff, G. Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3. Blood. 2002; 99(7): 2603-5.
3 }+ O9 P& o. ]0 R, Y4 {* hJegalian, AG Wu, H Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.. The Journal of biological chemistry. . 2002; 277(3): 2345-52.9 {4 q2 `5 e% S$ z& ?; z1 f1 _
Hisakawa, H. Sugiyama, D. Nishijima, I. Xu, M. J. Wu, H. Nakao, K. Watanabe, S. Katsuki, M. Asano, S. Arai, K. Nakahata, T. Tsuji, K. Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. Blood. 2001; 98(13): 3618-25.
1 U' o* `- z! XGroszer, M. Erickson, R. Scripture-Adams, D. D. Lesche, R. Trumpp, A. Zack, J. A. Kornblum, H. I. Liu, X. Wu, H. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. 2001; 294(5549): 2186-9.' \! c: C0 ~. |5 ` s- I9 d
Lee, R. Kertesz, N. Joseph, S. B. Jegalian, A. Wu, H. Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001; 98(5): 1408-15.
: p- U5 F4 r5 S/ o a# QNeshat, M. S. Mellinghoff, I. K. Tran, C. Stiles, B. Thomas, G. Petersen, R. Frost, P. Gibbons, J. J. Wu, H. Sawyers, C. L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001; 98(18): 10314-9.
* U$ ?+ b/ g& e7 ~4 E9 C: g' w; yDubey, P. Wu, H. Reiter, R. E. Witte, O. N. Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. Cancer Res. 2001; 61(8): 3256-61.
$ U2 l* t1 M& j4 ~/ hMakita, T. Hernandez-Hoyos, G. Chen, T. H. Wu, H. Rothenberg, E. V. Sucov, H. M. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev. 2001; 15(7): 889-901.
7 k# c0 E- f) Q j m8 rMamillapalli, R. Gavrilova, N. Mihaylova, V. T. Tsvetkov, L. M. Wu, H. Zhang, H. Sun, H. PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol. 2001; 11(4): 263-7. x6 f) b7 x) f8 j# c1 w
Satterthwaite, A. B. Willis, F. Kanchanastit, P. Fruman, D. Cantley, L. C. Helgason, C. D. Humphries, R. K. Lowell, C. A. Simon, M. Leitges, M. Tarakhovsky, A. Tedder, T. F. Lesche, R. Wu, H. Witte, O. N. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000; 97(12): 6687-92.
, ^& Z$ f, }! p5 c- wLiliental, J. Moon, S. Y. Lesche, R. Mamillapalli, R. Li, D. Zheng, Y. Sun, H. Wu, H. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000; 10(7): 401-4.
+ ~* C- P Q9 h5 t7 b- V3 J0 ZGhaffari, S. Wu, H. Gerlach, M. Han, Y. Lodish, H. F. Daley, G. Q. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc Natl Acad Sci U S A. 1999; 96(23): 13186-90.
; r. r* A% q6 `- PWu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML Inactivation of erythropoietin leads to defects in cardiac morphogenesis.. Development (Cambridge, England) . 1999; 126(16): 3597-605.7 J9 ^! H5 {. {8 j( x; F" o
Sun, H. Lesche, R. Li, D. M. Liliental, J. Zhang, H. Gao, J. Gavrilova, N. Mueller, B. Liu, X. Wu, H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A. 1999; 96(11): 6199-204.$ U( }8 s5 d& |9 W( S
Neubauer, H. Cumano, A. Muller, M. Wu, H. Huffstadt, U. Pfeffer, K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998; 93(3): 397-409.0 m, s/ L1 @! u9 ]+ V+ a+ u
Constantinescu, S. N. Wu, H. Liu, X. Beyer, W. Fallon, A. Lodish, H. F. The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid. Blood. 1998; 91(4): 1163-72.
0 L5 }. Z$ P) s& }2 [Klingmuller, U. Wu, H. Hsiao, J. G. Toker, A. Duckworth, B. C. Cantley, L. C. Lodish, H. F. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A. 1997; 94(7): 3016-21." Y) {2 z. b. l. F; d
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Liu, X. Wu, H. Byrne, M. Krane, S. Jaenisch, R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997; 94(5): 1852-6.
% @1 M4 u0 [3 E# ` P, B" _% x9 EKrane, S. M. Byrne, M. H. Lemaitre, V. Henriet, P. Jeffrey, J. J. Witter, J. P. Liu, X. Wu, H. Jaenisch, R. Eeckhout, Y. Different collagenase gene products have different roles in degradation of type I collagen. J Biol Chem. 1996; 271(45): 28509-15.1 u* {# k$ o5 E' K) ?) x8 _, s
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Wu, H. Klingmuller, U. Besmer, P. Lodish, H. F. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 1995; 377(6546): 242-6.
/ q" |2 C# E+ c& J8 r# n7 n% |- ZWu, H. Liu, X. Jaenisch, R. Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A. 1994; 91(7): 2819-23.
6 J% q; t3 x* m. BBarker DD, Wu H, Hartung S, Breindl M, Jaenisch R Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.. Molecular and cellular biology. . 1991; 11(10): 5154-63.
1 M7 O0 P5 X2 k$ jSilverman, D. H. Wu, H. Karnovsky, M. L. Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide release. Biochem Biophys Res Commun. 1985; 131(3): 1160-7.4 {* ~) S" |- Q6 [) N9 {
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发表于 2013-9-3 20:10
发表于 2013-9-3 21:09
