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北京大学生命科学学院新任院长：吴虹" ?0 ^9 I8 k* [$ r4 y1 n$ T/ B% n
2013-09-03 来源：生物360 作者：koo
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- j, [3 I6 I4 Q: Y吴虹，博士。美国加州大学洛杉矶分校分子和医学药理学系教授。美国加州大学洛杉矶分校分子遗传技术中心主任。JCCC癌症干细胞研究项目联合副主任。JCCC泌尿生殖系统肿瘤项目成员，信号转导研究及治疗项目成员，加州大学洛杉矶分校脑研究所成员。/ w4 f9 _0 `% ~0 h7 C
主要研究方向为肿瘤细胞信号转导及分子机制研究，曾以第一作者和通讯作者在Nature、Cell、Blood和PNAS等顶级学术期刊发表多篇有重要影响力的论文。 2011年被选为美国科学促进协会院士。
+ e1 g- n" I8 }6 N0 w6 b在北大医学院取得学士学位后，留学美国。在哈佛大学取得生物化学博士学位，麻省理工学院白头研究所博士后。其在UCLA的实验室主要进行肿瘤细胞信号转导及分子机制研究。
* P3 m5 m% i0 i% x& z2 W2013年9月3日，正式接替饶毅，担任新一任北京大学生命科学学院院长。) f/ q: k. M- N; G+ q# R
了解更多：
* k+ F: b2 I$ p: s# dWelcome to the Hong Wu's Lab! - UCLA2 [6 b: } l, n9 Z
代表论文：& Z) x. ^4 D6 L" U/ d2 Q. K! m g
Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.2 O5 t# O9 {, i3 I
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
8 R, }! E8 W/ a+ h, VWang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.6 B( ?% h( S' S" G, q- T+ [; M1 K
Xu, X. Kobayashi, S. Qiao, W. Li, C. Xiao, C. Radaeva, S. Stiles, B. Wang, R. H. Ohara, N. Yoshino, T. LeRoith, D. Torbenson, M. S. Gores, G. J. Wu, H. Gao, B. Deng, C. X. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006; 116(7): 1843-52.; i2 A7 Q! J, l+ Q2 D" a( L( }
Wu, H. Khodavirdi, A Roy-Burman, P. Capturing signal anomalies of human prostate cancer into mouse models. Prostate cancer: basic mechanisms and therapeutic approaches 2005; in press.+ }- |0 D V+ x3 ~% g0 o
Kurlawalla-Martinez, C. Stiles, B. Wang, Y. Devaskar, S. U. Kahn, B. B. Wu, H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.
# i6 H( t& c/ u2 q9 k1 h0 cLasky, J. and Wu, H. Notch signaling pathways, brain development and human disease. Pediatric Research 2005; in press.
! A7 k+ ]8 _8 Y7 F6 N( B6 V, _; f) qYue, Q. Groszer, M. Gil, J. S. Berk, A. J. Messing, A. Wu, H. Liu, X. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development. 2005; 132(14): 3281-91.
& V7 x' z- g, k @4 WStanger, B. Z. Stiles, B. Lauwers, G. Y. Bardeesy, N. Mendoza, M. Wang, Y. Greenwood, A. Cheng, K. H. McLaughlin, M. Brown, D. Depinho, R. A. Wu, H. Melton, D. A. Dor, Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95.
/ Y% t/ }( s# HKurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.( S/ n# O5 D" J+ E b/ }9 p, N; O
Lasky J, and Wu H Notch signaling pathways, brain development and human disease.Pediatric Research 2005; in press.; [5 h5 p- c* n8 n
Liu B, Yang R, Wong KA, Getman C, Stein N, Cheng G, Wu H, and Shuai K PIAS1 Participates in the Negative Regulation of NF-kB Signaling. Mol. Cell Biol. 2005; 25: 1113-23.
6 ] y" a( H$ V: g* |; ]. x0 [' mMulholland DJ, Dedhar S, Wu H and Nelson CC PTEN & GSK3?O: Key Regulators of Progression to Androgen Independent Prostate Cancer. . Oncogene 2005; in press.
# @; U" J/ R: G( v: [Sanchez T, Thangada S, Wu MT, Kontos C, Wu D, Wu H And Hla T PTEN as an effector in the signaling of anti-migratory G protein-coupled receptor. Proc. Natl. Acad. Sci. USA 2005; 102: 4312-7.
g0 v. r6 X* p& M" H- W4 O; u. F! ]Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization.Development. 2005; 132(14): 3281-91.
: Y; d* w& m v- z& D9 MStanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95. f- }3 b9 ^% u, Z
Roy-Burman, P. Wu, H. Powell, W. C. Hagenkord, J. Cohen, M. B. Genetically defined mouse models that mimic natural aspects of human prostate cancer development.Endocr Relat Cancer. 2004; 11(2): 225-54.
2 Y) m% ^% ~6 D& tSundaresan, G. Paulmurugan, R. Berger, F. Stiles, B. Nagayama, Y. Wu, H. Gambhir, S. S. MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18.
4 O/ e' ?; }! o d# X8 \Liu, B. Mink, S. Wong, K. A. Stein, N. Getman, C. Dempsey, P. W. Wu, H. Shuai, K. PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.5 M2 E& @& G, L0 Y7 k% T6 M' n/ x
Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004; 24(12): 5577-86. r, p, [9 @; _+ e* G
Roy-Burman P, Wu H, Powell WC, Hagenkord J, Cohen MB Genetically defined mouse models that mimic natural aspects of human prostate cancer development. Endocr Relat Cancer. 2004; 11(2): 225-54.3 |: i( L# L% H' d/ |( ?
Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18.9 U# K3 |+ ^! `. ~ x; I
Liu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.3 X4 h6 i6 M P, X
Wong, K. A. Tsai, P. T. Jegalian, A. Kertesz, N. Lee, R. Wu, H. Erythropoietin, biochemistry of.. Encyclopedia of hormones 2003; 561-569.& a! e0 e* B1 P0 C+ B
Freeman, D. J. Li, A. G. Wei, G. Li, H. H. Kertesz, N. Lesche, R. Whale, A. D. Martinez-Diaz, H. Rozengurt, N. Cardiff, R. D. Liu, X. Wu, H. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003; 3(2): 117-30.! g" b2 L- }0 m* a
Wang, S. Gao, J. Lei, Q. Rozengurt, N. Pritchard, C. Jiao, J. Thomas, G. V. Li, G. Roy-Burman, P. Nelson, P. S. Liu, X. Wu, H. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.( T! O+ e$ n6 ?
Anzelon, A. N. Wu, H. Rickert, R. C. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol. 2003; 4(3): 287-94.
, G" H: V6 w1 l C0 B* I$ d7 m! [Wong K, Tsai P, Jegalian A, Kertesz N, Lee R and Wu H Erythropoietin, Biochemistry of.. In Encyclopedia of Hormones. 2003; 561-569../ U7 P3 j1 |! ?1 H
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.Cancer Cell. 2003; 3(2): 117-30.
. l* W8 Y# Q9 u! j, j* h; {& X4 u6 oWang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.
7 b) }# a; S, C5 G: Z. ~" fLi, G. Robinson, G. W. Lesche, R. Martinez-Diaz, H. Jiang, Z. Rozengurt, N. Wagner, K. U. Wu, D. C. Lane, T. F. Liu, X. Hennighausen, L. Wu, H. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.Development. 2002; 129(17): 4159-70.! h$ g/ F4 h- c) K, c3 P2 z
Lesche, R. Groszer, M. Gao, J. Wang, Y. Messing, A. Sun, H. Liu, X. Wu, H.Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis.2002; 32(2): 148-9.6 y9 F: k l5 ~* o
Jegalian, A. G. Wu, H. Differential roles of SOCS family members in EpoR signal transduction. J Interferon Cytokine Res. 2002; 22(8): 853-60.5 E) m4 B1 I6 L; T* P5 ?' M
Stiles, B. Gilman, V. Khanzenzon, N. Lesche, R. Li, A. Qiao, R. Liu, X. Wu, H. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.Mol Cell Biol. 2002; 22(11): 3842-51.
* W* Y) m. m! ~. B) n7 pJegalian A and Wu H Differential Regulation of SOCS Gene Expression and Distinct Roles of SOCS family Members in Erythropoietin Receptor Signal Transduction.. J. Cyto.Research . 2002; 22: 3842-3851.! @5 u5 ~8 ]2 ~
Jegalian, A., Acurio, A., Dranoff, G., Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukine 3.. Blood . 2002; 99: 2603-2605.
& R$ u i3 N2 h7 \Makita T, Hernandez-Hoyos G, Chen T, Wu H, Rothenberg E and Sucov H A Developmental Transition in Definitive Erythropoiesis Controlled by Competitive Regulation of Erythropoietin Expression by Retinoid Acid Receptor and HNF4.. Gene & Devel.. 2001; 15: 889-901.% u8 s7 _! p `* y
Neshat M, Mellinghoff I, Tran C, Stiles B, Thomas G, Wu H, and Sawyers C Enhanced sensitively of PTEN-Deficient Tumors to Inhibition of FRAP/mTOR.. Proc. Natl. Acad. Sci. USA. . 2001; 98: 10314-1031.; M' ]; B6 f: G# y! |
Hisakawa H, Sugiyama D, Nishijima I, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K Human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF) Stimulates Primitive and Definitive Erythropoiesis in Mouse Embryo Expressing hGM-CSF Receptors but not Erythropoietin Receptors.. Blood . 2001; 98: 3618-3625.
$ L |5 Z% I& AMamillapalli R, Gavrilova N, Mihaylova V, Tsvetkov L, Wu H, Zhang H and Sun H PTEN Regulates The Ubiquitin-Dependent Degradation Of The Cdk Inhibitor P27kip1 Through The Ubiquitin E3 Ligase Scfskp2.. Current Biology . 2001; 11: 263-267.
+ K% j' G0 s6 `* f4 U: H) }; O5 E2 pWu, H. Lee, S. H. Gao, J. Liu, X. Iruela-Arispe, M. L. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development. 1999; 126(16): 3597-605.
. Z( ~0 z$ T# bSun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Garvarina N, Mueller B, Liu X and Wu H PTEN Modulates Cell Cycle Prograssion and Cell Survival by Regulating PIP3 and AKT/PKB Signaling Pathway.. Proc. Natl. Acad. Sci.. 1999; 96: 6199-6204. a) N& Y: N; M, b+ ~; c5 K
Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U and Pfeffer K Jak2 Deficiency Defines an Essential Developmental Checkpoint in Definitive Hematopoiesis.. Cell. 1998; 93: 397-409.
P: v/ I$ J) n: S1 N; uLiu, X. Wu, H. Loring, J. Hormuzdi, S. Disteche, C. M. Bornstein, P. Jaenisch, R. Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.
! [6 S- A8 R8 i4 u5 r, E- E* AWu H, Klingmuller U, Acurio A, Hsiao JG and Lodish HF Functional Interaction of Erythropoietin and Stem Cell Factor Receptors is Essential for Erythroid Colony Formation.. Proc. Natl. Acad. Sci. USA. . 1997; 94: 1806-1810.; X8 d3 \, ?& C
Klingmuller K, Wu H, Hsiao J, Duckworth B, Toker A, Cantley LC and Lodish HF Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.. Proc. Natl. Acad. Sci. USA . 1997; 94: 3016-3021.# d% w1 @) O. _6 r; D" E- O; z; P
Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.7 k) Y' V; v( G- \$ C
Watowich, S. S. Wu, H. Socolovsky, M. Klingmuller, U. Constantinescu, S. N. Lodish, H. F. Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 1996; 12: 91-128.
( L( |3 @1 M5 }5 ~Wu, H. and Lodish, H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.
& q# a7 [- n5 A6 L7 S3 {Iruela-Arispe, M. L. Vernon, R. B. Wu, H. Jaenisch, R. Sage, E. H. Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Dev Dyn. 1996; 207(2): 171-83.8 F" @3 T6 X2 h
Wu H and Lodish H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.$ C4 ^7 P% A7 u0 I
Iruela ML, Vernon RB, Wu H, Jeanisch R and Sage H Type I collagen is required for the association of SPARC with the extracellular matrix in Mov-13 mice: implications for fibroblast function.. Developmental Dynamics . 1996; 207: 171-183.5 \) a( l& v8 ]" n# \
Liu, X. Wu, H. Byrne, M. Jeffrey, J. Krane, S. Jaenisch, R. A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol. 1995; 130(1): 227-37.
+ O( s% h1 `9 B; I, A7 v6 Y, TLodish, H. F. Hilton, D. J. Klingmuller, U. Watowich, S. S. Wu, H. The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harb Symp Quant Biol. 1995; 60: 93-104.
4 S6 M5 s) y B. N/ b4 lDzamba, B. J. Wu, H. Jaenisch, R. Peters, D. M. Fibronectin binding site in type I collagen regulates fibronectin fibril formation. J Cell Biol. 1993; 121(5): 1165-72., A/ L% i2 }# }0 F
Hasty, K. A. Wu, H. Byrne, M. Goldring, M. B. Seyer, J. M. Jaenisch, R. Krane, S. M. Mainardi, C. L. Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase. Matrix. 1993; 13(3): 181-6.+ M- M( ?7 C2 T$ U4 [; T0 b
Wu, H. Fassler, R. Schnieke, A. Barker, D. Lee, K. H. Chapman, V. Francke, U. Jaenisch, R. An X-linked human collagen transgene escapes X inactivation in a subset of cells. Development. 1992; 116(3): 687-95.5 z8 y+ P$ \ x. b, q
Barker, D. D. Wu, H. Hartung, S. Breindl, M. Jaenisch, R. Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice. Mol Cell Biol. 1991; 11(10): 5154-63.
' g1 }0 ]4 S4 ~7 G) C- W. C7 EWu, H. Byrne, M. H. Stacey, A. Goldring, M. B. Birkhead, J. R. Jaenisch, R. Krane, S. M. Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc Natl Acad Sci U S A. 1990; 87(15): 5888-92.
# E- k/ {% O& r$ \Horvath, S. Zhang, B. Carlson, M. Lu, K. V. Zhu, S. Felciano, R. M. Laurance, M. F. Zhao, W. Qi, S. Chen, Z. Lee, Y. Scheck, A. C. Liau, L. M. Wu, H. Geschwind, D. H. Febbo, P. G. Kornblum, H. I. Cloughesy, T. F. Nelson, S. F. Mischel, P. S. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A. 2006; 103(46): 17402-7.5 l. |8 J( w5 [7 ?' s
Huang, W. Chang, H. Y. Fei, T. Wu, H. Chen, Y. G. GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene. 2006; .7 E/ F9 ^6 d' ]6 P# U8 ^4 `( s: Z
Freeman, D. Lesche, R. Kertesz, N. Wang, S. Li, G. Gao, J. Groszer, M. Martinez-Diaz, H. Rozengurt, N. Thomas, G. Liu, X. Wu, H. Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006; 66(13): 6492-6.
" \. w3 s3 H# {- S4 zZhang, J. Grindley, J. C. Yin, T. Jayasinghe, S. He, X. C. Ross, J. T. Haug, J. S. Rupp, D. Porter-Westpfahl, K. S. Wiedemann, L. M. Wu, H. Li, L. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.Nature. 2006; 441(7092): 518-22.. T# e$ ?. L% a% A" g2 O: U
Yilmaz, O. H. Valdez, R. Theisen, B. K. Guo, W. Ferguson, D. O. Wu, H. Morrison, S. J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006; 441(7092): 475-82.
( b" u- b+ P# r! r" v/ P- |Li, G. Hu, Y. Huo, Y. Liu, M. Freeman, D. Gao, J. Liu, X. Wu, D. Wu, H. PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. J Biol Chem. 2006; ./ J* o% t% t1 A8 @8 i. g& U
Yoo, L. I. Liu, D. W. Le Vu, S. Bronson, R. T. Wu, H. Yuan, J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner.Cancer Res. 2006; 66(4): 1929-39.
! h( F, m6 v/ t$ ZYao, D. Alexander, C. L. Quinn, J. A. Porter, M. J. Wu, H. Greenhalgh, D. A. PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways. Cancer Res. 2006; 66(3): 1302-12.
: Y d1 ] A* f! I, m6 SWang, S. Garcia, A. J. Wu, M. Lawson, D. A. Witte, O. N. Wu, H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.
' _- g5 M5 W# g) j2 H$ XTsai, P. T. Ohab, J. J. Kertesz, N. Groszer, M. Matter, C. Gao, J. Liu, X. Wu, H. Carmichael, S. T. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.3 s* x8 v# B) k
Mulholland, D. J. Dedhar, S. Wu, H. Nelson, C. C. PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene. 2006; 25(3): 329-37.
! l& P7 @% @/ TKhodavirdi, A. C. Song, Z. Yang, S. Zhong, C. Wang, S. Wu, H. Pritchard, C. Nelson, P. S. Roy-Burman, P. Increased expression of osteopontin contributes to the progression of prostate cancer. Cancer Res. 2006; 66(2): 883-8./ t: X: `1 E5 N5 G
Groszer, M. Erickson, R. Scripture-Adams, D. D. Dougherty, J. D. Le Belle, J. Zack, J. A. Geschwind, D. H. Liu, X. Kornblum, H. I. Wu, H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
" w; u+ h8 U6 ^ B3 zBerquin, I. M. Min, Y. Wu, R. Wu, H. Chen, Y. Q. Expression signature of the mouse prostate. J Biol Chem. 2005; 280(43): 36442-51.4 S5 Y7 N# Q4 `+ v K( o
Nakano, I. Paucar, A. A. Bajpai, R. Dougherty, J. D. Zewail, A. Kelly, T. K. Kim, K. J. Ou, J. Groszer, M. Imura, T. Freije, W. A. Nelson, S. F. Sofroniew, M. V. Wu, H. Liu, X. Terskikh, A. V. Geschwind, D. H. Kornblum, H. I. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.J Cell Biol. 2005; 170(3): 413-27.
3 H+ Y0 J( g( T6 g- QShi, Y. Sharma, A. Wu, H. Lichtenstein, A. Gera, J. Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. J Biol Chem. 2005; 280(12): 10964-73.
1 w) e' Y& d! J9 l! eSanchez, T. Thangada, S. Wu, M. T. Kontos, C. D. Wu, D. Wu, H. Hla, T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005; 102(12): 4312-7.1 e* {) P7 m$ {8 M2 w
Lim, M. A. Yang, L. Zheng, Y. Wu, H. Dong, L. Q. Liu, F. Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells.Oncogene. 2004; 23(58): 9348-58.
9 H3 U, G5 L1 l2 OKertesz, N. Wu, J. Chen, T. H. Sucov, H. M. Wu, H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004; 276(1): 101-10.
0 n3 g% ^% j; C& {% N9 p# r& a7 |Stiles, B. Groszer, M. Wang, S. Jiao, J. Wu, H. PTENless means more. Dev Biol. 2004; 273(2): 175-84." n- P: l& ~3 @) X1 _
Chang, C. J. Freeman, D. J. Wu, H. PTEN regulates Mdm2 expression through the P1 promoter. J Biol Chem. 2004; 279(28): 29841-8.
+ g; S( `. ]' d& x* F8 s DJohnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.. The Journal of biological chemistry. . 2004; 279(23): 24794-802.( e/ }0 }' \2 k5 O" ]' U s
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004; 101(7): 2082-7.8 i5 q' x$ K' X6 o
Tsai, P. T. Lee, R. A. Wu, H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Blood. 2003; 102(12): 3947-53.
: q& p2 `0 U! T3 f# MAnzelon AN, Wu H, Rickert RC Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.. Nature immunology. . 2003; 4(3): 287-94.
" t: X/ X, p1 {, o/ G' AOsawa, M. Yamaguchi, T. Nakamura, Y. Kaneko, S. Onodera, M. Sawada, K. Jegalian, A.Wu, H. Nakauchi, H. Iwama, A. Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood. 2002; 100(8): 2769-77." \& P- G$ L7 B, n1 ^
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.. Development (Cambridge, England) . 2002; 129(17): 4159-70.
/ X! ]' E I/ PKertesz, N. Samson, J. Debacker, C. Wu, H. Labastie, M. C. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene. 2002; 294(1-2): 13-24.7 L) }% v( D( I( s7 P
Jegalian, A. G. Acurio, A. Dranoff, G. Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3. Blood. 2002; 99(7): 2603-5.$ L* a) s: W% i1 z
Jegalian, AG Wu, H Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.. The Journal of biological chemistry. . 2002; 277(3): 2345-52.
& V8 O0 V2 _5 [, T/ j+ c. s! }Hisakawa, H. Sugiyama, D. Nishijima, I. Xu, M. J. Wu, H. Nakao, K. Watanabe, S. Katsuki, M. Asano, S. Arai, K. Nakahata, T. Tsuji, K. Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. Blood. 2001; 98(13): 3618-25.
5 Z) w+ Q* J5 W" @, I# ?! F( fGroszer, M. Erickson, R. Scripture-Adams, D. D. Lesche, R. Trumpp, A. Zack, J. A. Kornblum, H. I. Liu, X. Wu, H. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. 2001; 294(5549): 2186-9.4 G" L* H4 [7 L- I7 U5 P" K2 A" j+ c
Lee, R. Kertesz, N. Joseph, S. B. Jegalian, A. Wu, H. Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001; 98(5): 1408-15.
0 k& ~! Z2 I! F4 V+ ONeshat, M. S. Mellinghoff, I. K. Tran, C. Stiles, B. Thomas, G. Petersen, R. Frost, P. Gibbons, J. J. Wu, H. Sawyers, C. L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001; 98(18): 10314-9.+ C" i! _4 z3 @1 k! \% p+ A
Dubey, P. Wu, H. Reiter, R. E. Witte, O. N. Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. Cancer Res. 2001; 61(8): 3256-61.
+ W+ N. s! n+ S4 | i9 j& ZMakita, T. Hernandez-Hoyos, G. Chen, T. H. Wu, H. Rothenberg, E. V. Sucov, H. M. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev. 2001; 15(7): 889-901.
6 Q% Q% s( u/ q! Z9 h tMamillapalli, R. Gavrilova, N. Mihaylova, V. T. Tsvetkov, L. M. Wu, H. Zhang, H. Sun, H. PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol. 2001; 11(4): 263-7.3 B! H l* ~) i# k5 e
Satterthwaite, A. B. Willis, F. Kanchanastit, P. Fruman, D. Cantley, L. C. Helgason, C. D. Humphries, R. K. Lowell, C. A. Simon, M. Leitges, M. Tarakhovsky, A. Tedder, T. F. Lesche, R. Wu, H. Witte, O. N. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000; 97(12): 6687-92.
* y. J$ w( N+ w" _: L# ALiliental, J. Moon, S. Y. Lesche, R. Mamillapalli, R. Li, D. Zheng, Y. Sun, H. Wu, H. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000; 10(7): 401-4.
; p9 {' ?& I B2 w4 {( c+ qGhaffari, S. Wu, H. Gerlach, M. Han, Y. Lodish, H. F. Daley, G. Q. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc Natl Acad Sci U S A. 1999; 96(23): 13186-90.$ V9 S/ C- e/ `) K
Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML Inactivation of erythropoietin leads to defects in cardiac morphogenesis.. Development (Cambridge, England) . 1999; 126(16): 3597-605.
% ~! O) X! g+ f2 K$ s7 uSun, H. Lesche, R. Li, D. M. Liliental, J. Zhang, H. Gao, J. Gavrilova, N. Mueller, B. Liu, X. Wu, H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A. 1999; 96(11): 6199-204.* [& H2 W* [/ Y
Neubauer, H. Cumano, A. Muller, M. Wu, H. Huffstadt, U. Pfeffer, K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998; 93(3): 397-409.4 T8 b0 N0 g. k) @0 z* ?0 }
Constantinescu, S. N. Wu, H. Liu, X. Beyer, W. Fallon, A. Lodish, H. F. The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid. Blood. 1998; 91(4): 1163-72.
. F' F2 d5 y% t( e5 yKlingmuller, U. Wu, H. Hsiao, J. G. Toker, A. Duckworth, B. C. Cantley, L. C. Lodish, H. F. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A. 1997; 94(7): 3016-21.
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( R, R! [+ f' i/ a+ E1 _Liu, X. Wu, H. Byrne, M. Krane, S. Jaenisch, R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997; 94(5): 1852-6.- v- N1 t! d7 K
Krane, S. M. Byrne, M. H. Lemaitre, V. Henriet, P. Jeffrey, J. J. Witter, J. P. Liu, X. Wu, H. Jaenisch, R. Eeckhout, Y. Different collagenase gene products have different roles in degradation of type I collagen. J Biol Chem. 1996; 271(45): 28509-15.9 M1 ~& c5 J S+ M7 @1 W
Wu, H. Liu, X. Jaenisch, R. Lodish, H. F. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995; 83(1): 59-67.$ H6 j" G' Y+ U
Wu, H. Klingmuller, U. Besmer, P. Lodish, H. F. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 1995; 377(6546): 242-6.8 K- O) f0 A+ d" \
Wu, H. Liu, X. Jaenisch, R. Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A. 1994; 91(7): 2819-23.
: z7 }6 B) [( m$ W" |Barker DD, Wu H, Hartung S, Breindl M, Jaenisch R Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.. Molecular and cellular biology. . 1991; 11(10): 5154-63.
\- U6 N: ^8 l$ kSilverman, D. H. Wu, H. Karnovsky, M. L. Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide release. Biochem Biophys Res Commun. 1985; 131(3): 1160-7.8 ^, E4 Z3 g% C* Q
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发表于 2013-9-3 20:10
发表于 2013-9-3 21:09
