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可是这个版本(如果是,我就给你下):
: r- X4 i. b8 oTable of Contents
8 A1 w! W' n# Y$ m
. }" l( C! G' S% e/ d) uI. Principles of Developmental Biology/ c/ k+ ?9 ?+ P) k; ^
7 `+ ]6 _: j8 R1. Developmental biology: The anatomical tradition' @! O4 `( M8 F( i
New techniques of mathematical modeling of development: l& C8 S, h( G& h2 N2 K
2. Life cycles and the evolution of developmental patterns; X1 f% f {# M& Z' R
Recent advances in planarian regeneration
, @- @: m3 o; i4 Z `3. Principles of experimental embryology0 [; ~# R9 d& H; G* V
4. The genetic core of development4 q8 c. k* O+ ?7 L1 j, v
5. The paradigm of differential gene expression
# g' W0 l! B3 R* h0 i3 I+ bHistone modifications
) I2 w- i* Z" l, ^MicroRNAs
! S+ ?4 `8 l$ @0 lPioneer transcription factors3 T; {: x" \0 f. e
Mammalian cloning and methylation patterns, w" b. X! P' @* Y3 v/ y; c
6. Cell–cell communication in development0 {" i. H, \" [4 ]5 l' a
Stem cell specification and stem cell niches8 [1 v4 u7 \9 B
Morphogenetic regulation by cadherins
! Z3 l% `' Z$ Q# h/ m& ANoncanonical Wnt pathways. \& u0 W Z; j. y7 A' u
Dependence receptors and apoptosis
" a) u# t6 v+ p6 A. tCommunity effect and autocrine factors
1 j7 c; c# j2 m
, `2 M" W# \; U# a% ]% z4 z; uII. Early Embryonic Development! I: Z* m+ d& ^: S: Q( _2 V- w
0 [1 B- t$ c8 Y$ @+ ~* ^6 k2 E- q
7. Fertilization: Beginning a new organism
, c% H/ S7 s2 f) D& }+ n7 uCortical granule components
, c7 Q: _! n$ J, }/ UNew mammalian sperm–egg binding model: ?# \( R% I& K+ |" f# t
Mammalian sperm chemotaxis and thermotaxis
+ n" a0 U6 Z( B' FMechanisms of sea urchin sperm chemotaxis
0 J3 T9 X5 I7 i* v4 H6 F1 d9 hSea urchin bindin receptor
% |4 x7 t. K, S5 qOocyte translation inhibitors and their removal) T' y$ j1 \9 E' {4 V
New hypotheses of sperm activation9 _4 u! G- t. e3 k: _5 U
Mammalian sperm–egg fusion
5 g5 `5 K) X* x4 _( o' \% Y& T8. Early development in selected invertebrates
& t9 \8 s/ [* X6 L1 ?( G0 LWnt and Nodal in sea urchin axis specification
! P$ B' M8 i- k! C g( mCoiling genetics of snail embryos6 B* n# h' |3 Z7 `8 {$ ^) S/ R* Y8 R
Functions of tunicate yellow crescent
$ q2 e3 {0 {' r9 O( j1 bRoles of FGFs in tunicate development! @ F3 q! k( W) U* {
Tunicate heart development
6 }1 Z8 u) r( H# C: p, ~9. The genetics of axis specification in Drosophila
& Y. F, z- G: o* }2 XFGF signals and Drosophila mesoderm formation
: [9 o# [1 C. K4 V3 m* QTransport of Nanos and Bicoid messages to opposite ends of the fly oocyte
: u2 ?; L9 \" D! L2 y% K1 O+ lNew model for gap protein stabilization u- G( p0 I. F9 Z; q- j
10. Early development and axis formation in amphibians
: H1 |' F, l! z+ U9 @New models for organizer formation in Xenopus2 a! E3 J4 W" K. g
New model for mesoderm specification in Xenopus( q1 @) m& E4 l# L0 ?, p5 J* ~
11. The early development of vertebrates: Fish, birds, and mammals
, h' y% |4 K4 ^; Q; ]Maternal effect mutations in zebrafish
m" }- s# q8 e7 j k* E: yNeurulation in zebrafish. t/ H% W7 A" e: A1 H4 ?
Retinoic acid in anterior–posterior axis specification in chordates! Y, z w6 Q7 E J ~
Ciliary movements and left–right axis specification in vertebrates3 B# H8 w( R( Q
Role of Cerberus in chick head formation
3 ~. J. s) @) @" I8 d7 m9 WMesoderm specification and migration in chick gastrulae
" C# _5 R" ~$ I4 u& z, v9 |FGF and cell fate in chick and mammalian epiblasts
9 m- N: Z: Y) s4 b! s9 H! Q1 UInduction of pluripotency in mammalian inner cell mass blastomeres. E( `9 Y: T# j, w" ^
Homeotic transformation in mammals due to total Hox paralog knockouts A: p' \1 D0 r
Controversy over blastocyst polarity in mammals8 W' _& ?, m R4 s& Q
Folate receptors and teratogens affecting neurulation0 Q0 G7 b; A& N! `) U& I+ o
9 I8 q' g. M3 R: _2 W
III. Later Embryonic Development* W& z# |$ I1 }# d" z$ p: z# ?" T3 r+ C
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12. The emergence of the ectoderm: Central nervous system and epidermis
3 W& e4 g7 l2 g- G# p d. wGenes specifying neural fate
) k0 s$ [, } e6 y! Y% AHuman-specific genes specifying brain growth
( F; ?: t/ z' w8 f8 Z1 AProgressive myelination of the human brain; J: q X% X4 c' m0 ^! k$ p* x
Neural stem cells
+ B0 ^1 p; c" QEye development and blind cave salamanders
* ^! W# M& |8 @+ h# j9 @8 U0 tSkin, hair, and pigment stem cells
: i9 E, T/ n% ^6 f' a7 Z13. Neural crest cells and axonal specificity! l& |" |7 m+ S: {; G
Neural crest cell specification and migrations
; b9 s. N$ E4 a7 R3 G9 H3 eHead vs. trunk neural crest specification+ S' G3 L3 _9 v/ X& m+ a- T
Neural crest-endoderm interactions forming facial structures C( W6 F! u& m% _7 ?4 _$ M
Placode specification and separation
: N# Z* R. Y; }3 |7 U; R9 t$ VTooth development and evolution6 d" ^$ N; x4 u/ N
Semaphorins, Robo, and ephrins in neural patterning
( N# b# X6 l# j7 h, ~& A14. Paraxial and intermediate mesoderm
1 h# r. A8 ~+ ~& y. U! gSpecification of paraxial and intermediate mesoderm
) m) a, H% f' kEpithelialization of somites
( ~$ c9 y2 c r( }' e: TThe syndetome—where tendons arise
" M& t0 U' N2 zFGFs, Notch, and Wnt in somite specification and separation
0 E2 C9 \' u. D' c) V# i \The primaxial and abaxial musculature5 }: X$ [$ R6 k6 [ E
New sources of muscle precursor cells; Y w |" b( ^% Q6 H
Pathways of skeleton formation
3 j/ [3 T% T( f) x7 _Regulating ureteric bud branching
$ U( J# \- v; M/ o! R0 UWnt and FGF proteins regulating nephron formation: B* I( O6 T& y" M
15. Lateral plate mesoderm and endoderm9 q$ T! E8 p8 L$ j2 c4 b
Cloaca formation" S0 w' Q }6 K& u$ ~
Heart cell specification; v' `( |5 E: f1 l
Tbx genes, retinoic acid and heart chamber formation
5 L- K/ F: S! Y+ @Heart valve development
! B- I# @ u7 t1 N2 ~8 p6 yHematopoietic stem cells and their derivatives7 C& ~' `+ p6 @/ w6 k# m2 M
Lymphatic development
+ K- d. {; V YInduction of arteries by neurons$ w7 Q9 w2 A; d. S
Placenta as source of blood stem cells
u: m' v1 {) t9 j$ C5 c) q* oAdult blood stem cell niches
' f [9 j! G# J M7 x& X9 l6 qEndoderm specificity
# Y* n6 \7 O1 S+ u$ ?Pancreas vs. liver development6 v7 {! n3 M: Z; s$ @
Fate mapping pancreatic cells3 E* I% i: y R% y
16. Development of the tetrapod limb, J5 P8 c; D7 r% \
Hox code of limb development
7 k" z3 o1 \7 S- U( S; h$ iSpecification of the digits by hedgehog proteins and HoxD genes! R- U) |8 e# `& }% u" T
Controversy over digit identities in dinosaurs and birds
2 u+ O: { Q! a) m$ G- pGetting limbs from fins
0 g J5 x4 [1 e0 I8 e6 ^% F* U+ @17. Sex determination
3 D0 S7 w2 ], M4 l. p& _Timing and gene expression in mammalian sex determination
0 {; D8 g% ^+ b9 a6 z6 z2 gBrain sex determination pathways in vertebrates and flies
/ e5 H) Y o: V+ U- b& ^Hormone disruptors and sex determination problems
! i3 H; W: d3 f3 ADosage compensation and sex determination) T' h0 Z8 U/ T# M. c9 i
Temperature-dependent sex determination in turtles
+ L; h2 w9 _: S, H- b18. Metamorphosis, regeneration, and aging
$ s/ r0 E: P+ v4 G* OMolecular mechanisms of amphibian metamorphosis
, K$ f+ O; Y2 mEcdysone receptors and the response to molting hormone
) I& e+ V2 D% u; R4 U8 kCompartment formation in the wing imaginal disc
* y4 N* g) N! JWhy can’t we regenerate our limbs?* P8 h9 X5 Q: y
Neuron- and mesenchyme-dependent stages of limb regeneration
) q3 C0 j& w/ N# RSpecification of limb regions by transcription factors during regeneration8 w! Q+ \ e9 V& B) Q5 F) X
Mitochondrial control of aging% J0 v, N |+ q) s4 C; ]% S
Insulin pathway control of aging and possible relation to oxygen radicals
# T5 [- f2 ~+ C$ e9 ^% I“Ageless” animals and environmental control of aging/ ?* _+ p) [- U8 M# g/ c
19. The saga of the germ line: g! L" g- N$ {# p3 t" Z9 A
Genetic specification of germ-line cells in Drosophila and vertebrates' D! ]$ y" k; q* W! s1 _) J
Components of the Drosophila germ plasm8 j, G1 b9 X* I0 g2 G8 {
Egg and sperm stem cell niches in Drosophila
1 b% U# \6 U* o1 g" N# @Migration of primordial germ cells in mammals, chicks, and flies
) H8 J, D3 [) {Determination of meiosis and mitosis in C. elegans
0 ^' ~5 ~' V4 i) U! O# r5 J1 r- d9 aRetaining mammalian spermatic stem cells, ~/ _' t* @4 U0 o
IV. Ramifications of Developmental Biology8 b$ H+ d/ ]! C0 x
20. An overview of plant development
; Z/ ?* N! o$ y4 p \1 P4 Q5 @, Y% YGamete formation and pollen tube guidance" r4 O- }6 {1 y$ y/ t- Q* o
Maternal effects and embryo development6 U2 h( b! p. _0 R1 k' R
Radial and axial patterning# t- c! Y ^/ Z" r. i/ O' k( E
New model for auxin specification of polarity
' Z4 k7 n# K& C, `& l) w7 ~Roles of microRNAs in plant development
$ P( C" f, @& j- ?9 t2 [Dorsal–ventral leaf patterning
# ^6 S. K6 v1 dLong-distance RNA transport and flowering
8 X! ]/ K% T1 eFloral meristem specification
! Q7 X7 N; M( n! F21. Medical implications of developmental biology4 N( t* u1 o" m& l. v! N& v
Mechanisms of alcohol teratogenesis
) H/ \8 z% h, n2 N5 i5 `Effects of endocrine disruptors on human development3 o/ W8 X+ W. F {5 B) c- z
Nutritional effects of gene methylation and disease susceptibility
; F. _1 Y1 ~. ~& m, C$ oCancer as a disease of development6 K% ~0 [+ H9 k+ S" `8 m2 L
Cancer stem cell hypothesis# F) N; W' I) ]7 ]% L
Developmental approaches to cancer therapy3 g, m s! b. }9 x0 d3 o' X
Stem cell therapeutics$ [$ g+ L3 |0 R! I
Regenerating human limbs and neurons+ i9 s* T4 w4 @
22. Environmental regulation of animal development* d8 g6 ~' P( [, H4 F, E7 J
Molecular bases for environmental regulation of gene expression+ N+ Q6 C! \( [
• Importance of symbionts in mammalian gut and immune system
, ?6 ~& l8 q5 G2 w- Mdevelopment
! l: p- }* h# g$ O, \9 TSignaling from fetal mammalian lung to initiate labor" a7 r2 s: ?2 h" ?' O5 Q
The role of nutrition in the development of the dung beetle% b1 r# M8 `& H9 p8 ?
Predator-induced polyphenism and toxicity testing
4 Q) a$ p, h- y. l. NGenetic assimilation of environmentally induced traits+ M$ s! h% i' k7 j. P* G$ |2 @
23. Developmental mechanisms of evolutionary change
; m" P, X3 l! D4 c$ fDevelopmental modularity and evolution (stickleback studies)" V7 u9 Q0 Z b, X4 Z
Evolution by heterochrony, heterotopy, heterometry, heterotypy
9 u2 W6 ?) p# w- lBMPs and Darwin’s finches' Y' y7 w( H9 h2 B G
Origin of neural crest cells and the origin of jaws
( Q% M. J" d: {6 ^9 h5 \The search for the Urbilaterian ancestor |
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