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可是这个版本(如果是,我就给你下):. I/ t: \ M) r2 ^$ k1 ^/ O
Table of Contents- }' \, \+ N) \; O1 J! T# }
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I. Principles of Developmental Biology
" Q( r$ c- ]8 q
5 W7 d# F; b( d( C+ J1. Developmental biology: The anatomical tradition
; v7 \2 G5 t% U, \8 W2 ^New techniques of mathematical modeling of development0 l* z; F. A; C7 N i
2. Life cycles and the evolution of developmental patterns
9 f* L. q) d4 R: l) X8 ?7 VRecent advances in planarian regeneration
$ s+ D$ ~3 o" n2 ~" z. z3. Principles of experimental embryology6 A; ~7 l% |3 W4 R
4. The genetic core of development
% ]5 t/ k& e# R2 O+ M5. The paradigm of differential gene expression* P+ @2 }: E$ O' ?9 p& \
Histone modifications
+ A0 `% r+ r7 L2 eMicroRNAs- \2 F! g& p, m
Pioneer transcription factors
; O$ B) @ M N7 M& J$ y* M4 vMammalian cloning and methylation patterns
& Z3 B( w5 s4 f6 q) p2 O' l" m5 ^, W6. Cell–cell communication in development
1 N3 a z0 T" _" f# G! EStem cell specification and stem cell niches
" n$ {( ?. x" W% F4 ^, {" s" }4 P% lMorphogenetic regulation by cadherins
3 r2 O* z0 _* {$ R. [/ Y* H* G+ ?Noncanonical Wnt pathways. i9 [( k. m- Y: X# J8 d& R
Dependence receptors and apoptosis
! l1 d5 i F1 T' l4 S" A3 OCommunity effect and autocrine factors
- g7 `6 S5 b# W I
& }% U& [2 N) M; m+ ^II. Early Embryonic Development a7 o$ Z/ y6 ?' m/ f4 m6 N: R S
+ z) g( ?3 z1 T! I7. Fertilization: Beginning a new organism$ D: Q+ {6 I+ @. x) v/ W
Cortical granule components
# {4 i. T' {7 T& @2 ~New mammalian sperm–egg binding model
3 j+ A' w5 a6 J6 x) l0 XMammalian sperm chemotaxis and thermotaxis
8 X, _# r c# r2 _6 G% {: NMechanisms of sea urchin sperm chemotaxis0 t* ]1 h+ e3 S& X( |7 p n q
Sea urchin bindin receptor
$ @, a3 c7 H5 U, p. ~Oocyte translation inhibitors and their removal/ B9 N0 L1 o! f
New hypotheses of sperm activation
- F5 Y C# N L( W! iMammalian sperm–egg fusion/ v* y8 b; c9 T4 F Y
8. Early development in selected invertebrates% V- D# \& K/ |* w
Wnt and Nodal in sea urchin axis specification
# V. @! z6 d3 {) k; q7 Q( ^8 nCoiling genetics of snail embryos
8 Q) |9 n* L0 Y, E: a8 I' D% \0 y* XFunctions of tunicate yellow crescent
5 W* g, H$ i' F |1 ?: Z; pRoles of FGFs in tunicate development
; f, X: G; u. CTunicate heart development
+ }# ^; h/ b! t5 Y9. The genetics of axis specification in Drosophila) ^2 b, n* c+ ~$ y. A
FGF signals and Drosophila mesoderm formation
. z2 [% }9 S( I" p: J/ N2 bTransport of Nanos and Bicoid messages to opposite ends of the fly oocyte5 I+ \* I A- J" w
New model for gap protein stabilization
3 }. G: ^0 U5 m# m10. Early development and axis formation in amphibians
5 |7 C# k% L6 X5 B7 G7 ZNew models for organizer formation in Xenopus
6 r1 [: Y; w* ?9 G* H1 y3 p" nNew model for mesoderm specification in Xenopus; Q) B! F/ `- \6 W
11. The early development of vertebrates: Fish, birds, and mammals9 U: C/ H" n# d6 u
Maternal effect mutations in zebrafish9 i" k ]3 c8 D; S7 G
Neurulation in zebrafish
( I4 f- h7 R6 o9 {# J @Retinoic acid in anterior–posterior axis specification in chordates
! J; |% i" V) V1 ^0 lCiliary movements and left–right axis specification in vertebrates2 I; W, Y% D% R% L# _' d9 R. R. ]
Role of Cerberus in chick head formation h6 z2 ]% F1 w
Mesoderm specification and migration in chick gastrulae; M8 D3 O+ w9 u; N' Y2 \0 x
FGF and cell fate in chick and mammalian epiblasts
) ?! X+ [4 k9 zInduction of pluripotency in mammalian inner cell mass blastomeres) `) m/ v, B$ r8 ` ~* O
Homeotic transformation in mammals due to total Hox paralog knockouts! ^2 L# g, a! P* }1 p1 ^4 e2 \
Controversy over blastocyst polarity in mammals8 o- H* G! _/ U4 w3 R5 {
Folate receptors and teratogens affecting neurulation2 c. e/ P7 ]# `" n% v
' l+ ^5 L3 F0 y7 c4 TIII. Later Embryonic Development
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12. The emergence of the ectoderm: Central nervous system and epidermis i: `/ T# f6 V' @7 u
Genes specifying neural fate
P% [; U3 e8 zHuman-specific genes specifying brain growth
( V0 e) |2 |8 [; iProgressive myelination of the human brain
9 ]# l8 Y& N( YNeural stem cells: O; j6 |1 V9 E" Q
Eye development and blind cave salamanders
0 d j( t! S: b! k5 H6 XSkin, hair, and pigment stem cells
# t' `* j4 Q9 V/ i13. Neural crest cells and axonal specificity
2 P* [" [6 ^* k: Z6 o" a5 q! ONeural crest cell specification and migrations$ V2 K. q7 h" @0 M" Q2 H. g! p
Head vs. trunk neural crest specification/ I2 G S% C7 y- `. u2 {
Neural crest-endoderm interactions forming facial structures
7 h$ m ]; N0 X, q8 iPlacode specification and separation
" h0 j/ F. o- V0 f, S6 h' kTooth development and evolution
. ?3 W( d6 d$ M: MSemaphorins, Robo, and ephrins in neural patterning3 N- k# w( ] x% V C& r
14. Paraxial and intermediate mesoderm
2 l- |$ G! O' ^3 ?; SSpecification of paraxial and intermediate mesoderm+ e d6 t7 r7 T* d9 a
Epithelialization of somites x3 G& P7 s7 y2 ~0 d
The syndetome—where tendons arise& ~/ P. i0 J6 i6 X# S: U/ c( i
FGFs, Notch, and Wnt in somite specification and separation5 l7 `) W$ T1 v
The primaxial and abaxial musculature
+ Y3 M8 |" W) E m% ~" tNew sources of muscle precursor cells2 n, E! D$ Q* S
Pathways of skeleton formation9 M8 g7 `/ f+ p+ R- D- Q. T P% Z) _
Regulating ureteric bud branching9 x" O: U) U8 C+ X/ Y
Wnt and FGF proteins regulating nephron formation& z, P2 B' N0 [
15. Lateral plate mesoderm and endoderm4 v. j3 O5 y" ~6 P# c. ^( X
Cloaca formation9 c# y* R4 i# B9 z9 P8 D0 g4 B
Heart cell specification& {; k3 c/ C& o. i* v. y2 x
Tbx genes, retinoic acid and heart chamber formation9 d" C% u7 |% s# [2 n
Heart valve development
0 I) r( r4 \9 B# }0 _) VHematopoietic stem cells and their derivatives1 P8 A9 `, K9 T8 a" m7 e9 C
Lymphatic development5 S5 s( \) C! Q6 l
Induction of arteries by neurons9 j, A4 j [' Y! v" Y
Placenta as source of blood stem cells; I3 C( L- U: _4 U8 b
Adult blood stem cell niches$ }$ L, H$ r0 [
Endoderm specificity/ a# M3 C! u7 T" M& x _1 u9 s
Pancreas vs. liver development
( Z X4 w, Y! W: L& MFate mapping pancreatic cells* E& `& K( Q( L* O1 h
16. Development of the tetrapod limb
. ]* T3 I) m9 L: I! W; r/ XHox code of limb development
4 N) z+ @' l8 b$ xSpecification of the digits by hedgehog proteins and HoxD genes7 Q5 V* a' @2 o. I9 f% R" I6 _9 y. A I
Controversy over digit identities in dinosaurs and birds
6 M! N" I x( BGetting limbs from fins
2 v: ~8 x( @/ C& R" z" ~17. Sex determination
) _( {8 }# _0 h( cTiming and gene expression in mammalian sex determination
4 s) j* {, ~6 O- d: D8 _Brain sex determination pathways in vertebrates and flies
2 l( X% s5 q1 g- l2 bHormone disruptors and sex determination problems
* E+ s" O6 b' r; IDosage compensation and sex determination
+ h; w. s) ?+ W- r5 d) }Temperature-dependent sex determination in turtles4 J/ @# G2 _" h3 k
18. Metamorphosis, regeneration, and aging
$ N5 q% C3 W# H2 \- P1 Q5 LMolecular mechanisms of amphibian metamorphosis( E2 _" D, U0 ] }7 ? l: K* S2 {
Ecdysone receptors and the response to molting hormone
% p. Q0 F& p( X" p# g) iCompartment formation in the wing imaginal disc
. m9 ^' X& K; q" \Why can’t we regenerate our limbs?, j8 I8 f5 l% F' O& _% \2 t4 M Y
Neuron- and mesenchyme-dependent stages of limb regeneration7 L% L; P4 _4 E8 Q% N6 @, O( c
Specification of limb regions by transcription factors during regeneration
5 L- f& D& D! V( n1 _Mitochondrial control of aging( ~7 A' I- p. x: r2 c
Insulin pathway control of aging and possible relation to oxygen radicals
! `5 E, h' n8 w4 `3 ~4 V“Ageless” animals and environmental control of aging
0 c, U9 `9 N' q# G19. The saga of the germ line+ j# x; Z$ p0 ]- V$ r- X; h6 L
Genetic specification of germ-line cells in Drosophila and vertebrates l: X D9 A9 P2 N
Components of the Drosophila germ plasm# k6 H/ z; C, ~" T
Egg and sperm stem cell niches in Drosophila; E5 G' S% \: H1 P* N4 _" r+ c
Migration of primordial germ cells in mammals, chicks, and flies# O% Z V s: L+ a$ W9 P
Determination of meiosis and mitosis in C. elegans
, Q! ]4 e. R' S) @Retaining mammalian spermatic stem cells. g6 h) X% |( z, s' [1 [
IV. Ramifications of Developmental Biology* ~# G- Q5 s, i( d' b
20. An overview of plant development
% V: ^5 R/ l" r' C/ [3 GGamete formation and pollen tube guidance) ^: G2 u- l& r7 n
Maternal effects and embryo development. r& K+ B1 W. {0 L! x3 v
Radial and axial patterning
s( q( l8 g/ i' ~New model for auxin specification of polarity+ u6 m" ~: \: U q) g) `
Roles of microRNAs in plant development: ~0 V( W" \: J5 Y' U
Dorsal–ventral leaf patterning6 S3 s6 S: e1 f
Long-distance RNA transport and flowering$ i5 G1 ~7 Z" Y+ r
Floral meristem specification
- O+ b" b) R3 J/ P21. Medical implications of developmental biology/ \; f1 ?+ i9 M+ f
Mechanisms of alcohol teratogenesis
) O, d: T) ~" t0 B8 k5 T9 Z5 mEffects of endocrine disruptors on human development5 R! h& o; C% p% d2 ]
Nutritional effects of gene methylation and disease susceptibility. ~9 S' g+ _$ N u' B2 Q( `* w4 _. d
Cancer as a disease of development/ V, T2 T6 |. W6 T' c, w+ P
Cancer stem cell hypothesis6 [( ?* u" _# |( s
Developmental approaches to cancer therapy
( ?% D' A+ M) Q8 f. }- vStem cell therapeutics# E$ I9 }4 O. ]0 K0 ?9 {! Q! Q
Regenerating human limbs and neurons; N0 \3 G) n5 y: ~3 j
22. Environmental regulation of animal development
' N2 ?3 ^4 p* Y% W, W- i# \, DMolecular bases for environmental regulation of gene expression
; G4 w3 \9 F. X: Q• Importance of symbionts in mammalian gut and immune system
- }8 n& l e+ p$ a. D. ]0 _; a1 @" D5 ldevelopment2 O( N y* p4 o! B, y
Signaling from fetal mammalian lung to initiate labor J7 l$ x6 R2 [6 l
The role of nutrition in the development of the dung beetle. R0 u, e# V2 v: |/ l
Predator-induced polyphenism and toxicity testing
# e- |7 g4 a3 I# \# n# p5 D& qGenetic assimilation of environmentally induced traits8 @! S a) s" ?
23. Developmental mechanisms of evolutionary change! I! t* ?: K2 d
Developmental modularity and evolution (stickleback studies)
6 s6 p! G6 v: J6 y E: REvolution by heterochrony, heterotopy, heterometry, heterotypy
% L8 [: a, g# F" y5 l- D1 p% gBMPs and Darwin’s finches
8 ?7 V* x$ G6 Z( FOrigin of neural crest cells and the origin of jaws
5 k- r9 Q8 h9 m% W5 oThe search for the Urbilaterian ancestor |
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