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Cell, Vol 130, 581-585, 24 August 2007$ x5 U! A/ r: o) a
Essay6 k5 x, d6 o, B" ~" U8 w
4 S* P7 D* y* |4 u6 X* Q5 emicroRNAs: A Safeguard against Turmoil?
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Anthony K.L. Leung1 and Phillip A. Sharp1,
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5 c( N6 U* ^. e3 {2 h1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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: E- k; v9 i/ WCorresponding author
1 y& g( }/ u1 E% `$ \% B; C1 I* {Phillip A. Sharp* c& y0 b" L, w( V9 j/ M) d2 w# L
sharppa@mit.edu
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Summary
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) H5 k; n# V( w& V; R/ j3 GEmerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained by new interactions of miRNA/Argonaute complexes with RNA-binding proteins that relocate from different subcellular compartments during stress. |
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发表于 2010-1-11 10:00
