Nature子刊： 干细胞疗法可帮助治疗猴子心衰

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2018-7-2《自然-生物技术》Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates
7 l5 a: z7 V7 G6 @1 }将人体心肌细胞移植到患有心衰的猴子身上可以极大地修复其破损心脏的供血能力
; [4 m0 ]1 x) a5 o在猴子身上的这一发现将推动人体胚胎干细胞疗法在人类患者身上进行临床试验- C* [2 P# H; F! P4 k* k6 b4 A
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Pluripotent stem cell–derived cardiomyocyte grafts can remuscularize substantial amounts of infarcted myocardium and beat in synchrony with the heart, but in some settings cause ventricular arrhythmias.3 R/ A% `( k; M
It is unknown whether human cardiomyocytes can restore cardiac function in a physiologically relevant large animal model. 4 G1 s$ o* ?6 U$ P/ D- k' \, t) V
Here we show that transplantation of ∼750 million cryopreserved human embryonic stem cell–derived cardiomyocytes (hESC-CMs) enhances cardiac function in macaque monkeys with large myocardial infarctions.
. C" N+ F4 x& t* q5 y9 n1 IOne month after hESC-CM transplantation, global left ventricular ejection fraction improved 10.6 ± 0.9% vs. 2.5 ± 0.8% in controls, and by 3 months there was an additional 12.4% improvement in treated vs. a 3.5% decline in controls.
; W" P) `" i$ VGrafts averaged 11.6% of infarct size, formed electromechanical junctions with the host heart, and by 3 months contained ∼99% ventricular myocytes.
  u" T) @! O. |4 J A subset of animals experienced graft-associated ventricular arrhythmias, shown by electrical mapping to originate from a point-source acting as an ectopic pacemaker. . ^( B7 i* l" ?2 q& _4 U* k
Our data demonstrate that remuscularization of the infarcted macaque heart with human myocardium provides durable improvement in left ventricular function.( Y9 Y( [4 U& @9 Z6 q

1 r. s; n* j7 K% u# X1 [$ d0 [网址 https://www.nature.com/articles/nbt.4162( @4 N8 e; ?  v, r/ d

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