比内皮祖细胞来源有哪些？

bjchen789

内皮细胞除了从外周血提取，脐带血，脐静脉等提取，想问一下，骨髓中有EPC吗？还有哪些来源？比如胚胎那个组织。

风再吹起

成体组织中，骨髓中EPC含量是最高的，约是外周血的15倍，胎肝中也有EPC

chinajinlei

成体组织中，骨髓中EPC含量是最高的，约是外周血的15倍，胎肝中也有EPC
) U9 H, M. N* S; @) j# j& \风再吹起 发表于 2010-5-5 22:30

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    是的，骨髓中含量丰富

chinajinlei

外周血EPC其实来源于骨髓，骨髓中含有大量的干细胞和祖细胞，相对于外周血和脐血来说，其中EPC的含量更为丰富，且增殖能力更强。而且骨髓细胞具有易于获取和体外扩增，属自体来源，用于移植治疗无免疫排斥等特点。

henryjia

脐带血，脐静脉提取作为无创伤性来源备受关注，特别是对于幼儿心血管先天疾病患者，尤其有意义。在国外，获得伦理道德（ETHICAL APPROVAL）审核是很难的，脐带血是必然首选。  }+ x0 ?6 B' W" S, Q, y8 {) n
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‘Recently, endothelial progenitor cells (EPCs) were isolated from peripheral blood CD34, Flk-1, or AC133 antigen-positive cells, which are considered to include a hematopoietic stem cell population, ’ 通过这一段描述不难发现其实和MSC一样，EPC也是某一个细胞群，而不是单一的细胞种类。相信今后会有很多来源发现。

henryjia

感谢海洋兄的鼓励，继续补充有用的信息。5 i- R8 X2 x7 L. K5 I

: y. s$ K! q* N! T9 R6 O信息来源《Endothelial progenitor cells for postnatal vasculogenesis》+ }9 N: \; Y, `5 ~7 |' D
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In the past decade, researchers have defined committed stem or progenitor cells from various tissues, including bone marrow, peripheral blood, brain, liver, and reproductive organs, in both adult animals and humans. Whereas most cells in adult organs are composed of differentiated cells, which express a variety of specific phenotypic genes adapted to each organ’s environment, quiescent stem or progenitor cells are maintained locally or in the systemic circulation and are activated by environmental stimuli for physiological and pathological tissue regeneration.
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  C+ d" l3 O  L$ ]- h! m. P可见脑，肝脏，生殖器官组织也可能是其潜在来源。& D. W; r4 e- F1 V5 y- h7 W+ A

( K6 W/ V+ ]# g, S7 U附原文在此：

chb611301

现在有实验室，用内皮祖细胞诱导神经系统分化，治疗脑卒中，我也想问问各位大虾们，这样做和MSC相比哪个更好，应用于临床更实际呢