SCIENCE心脏祖细胞文章

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Cardiogenesis and the Complex9 V+ h$ W8 w2 F. Q% R
Biology of Regenerative& c+ `2 R9 q/ S' j2 l: J0 t
Cardiovascular Medicine7 t* |5 D: G( W7 l
Kenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3+ @1 J/ u6 G  v. c# o. R' b
The heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle/ c+ ]. g9 c' @
cells. Understanding the pathways that drive the formation, migration, and assembly of these cells$ l  j. [0 D  Y) [) t
into the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is3 F8 v# u8 |! A8 p
a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo# a  b* K: l: P0 O) I& w7 I2 s
cardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These- {' P& ^% x# I) H
progenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and; g" z8 R  S' o6 z, V5 h. R
ultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering# k) k7 y% C& ]4 h0 @2 H
technologies with patient-specific cardiac progenitor biology holds great promise for the" r" l5 _7 G, o3 ^0 ]2 U
development of human cell models of human disease and may lay the foundation for
0 v5 g+ @& e/ C* ~9 L/ Bnovel approaches in regenerative cardiovascular medicine.

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