SCIENCE心脏祖细胞文章

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* T" a5 x& N  l+ y. u2 Y  S% i7 oCardiogenesis and the Complex" i1 C: Z  a* s  G; L
Biology of Regenerative9 n7 k3 O& C, j3 t
Cardiovascular Medicine
7 A0 g+ p4 R7 s2 h$ V: nKenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3
  y  O( b" f4 u- l' ?The heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle
! v9 f" _' K  a- K; J. [5 ccells. Understanding the pathways that drive the formation, migration, and assembly of these cells9 v8 o! a. Z0 C& U
into the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is: [, U' Z" ~- T4 E
a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo. z: a: m7 c5 i' H$ z
cardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These
9 @2 B# O' \2 ^+ Sprogenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and6 X' t* h0 u) R6 k
ultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering4 D" G( \9 s; R  I7 Q1 H' Y( |
technologies with patient-specific cardiac progenitor biology holds great promise for the1 h8 `% w* P2 d: E- }0 T9 |
development of human cell models of human disease and may lay the foundation for
' }) Z: A1 x0 R& ^4 s- _% rnovel approaches in regenerative cardiovascular medicine.

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