SCIENCE心脏祖细胞文章

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Cardiogenesis and the Complex  A# V! B7 }& Y$ R
Biology of Regenerative
8 c- d' ?3 ?: MCardiovascular Medicine
* }. S4 N7 X4 B* A# S0 WKenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3
7 @8 B9 ^- C. H: F) _& {9 LThe heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle
. n1 y" O* H) [/ ucells. Understanding the pathways that drive the formation, migration, and assembly of these cells
* `* y: d+ }9 _5 O3 W: `into the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is7 ?, k1 b- S3 T2 D
a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo" h. R8 @; a8 {7 ^# T
cardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These6 c5 t* X, B7 ^8 O: n: I% Y
progenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and
# M+ G0 K( N8 \4 J: d" Iultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering+ J5 k, }& ]0 z: o, g( w7 x
technologies with patient-specific cardiac progenitor biology holds great promise for the
) E* ]7 q, g4 l( ]) zdevelopment of human cell models of human disease and may lay the foundation for* e1 }1 Q; ^! I
novel approaches in regenerative cardiovascular medicine.

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