SCIENCE心脏祖细胞文章

jianlindunev

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Cardiogenesis and the Complex* C  v/ m- {) b0 A/ W
Biology of Regenerative
* F) Y9 |- S* \4 O% @Cardiovascular Medicine' N7 p8 O. ]8 W! d" J
Kenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3
! N" E/ s$ V! \The heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle
, k9 i0 i! c# K4 W. P; M9 ]9 Icells. Understanding the pathways that drive the formation, migration, and assembly of these cells
' o9 N# V0 N: |2 t) @into the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is) V/ |2 N* `5 a& F, M7 T( E
a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo
( [) ?, Y- X, K6 d, M+ U& `cardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These7 J% I: b" C  \! V( |" }) ^6 w
progenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and% S8 v' w) q& i2 v3 ~/ P! Z( Y
ultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering, A( C) \: o* w0 ^
technologies with patient-specific cardiac progenitor biology holds great promise for the
+ Z3 ?$ f+ {. x. q# |6 mdevelopment of human cell models of human disease and may lay the foundation for  y4 k8 i6 k: I. v  J( J: R
novel approaches in regenerative cardiovascular medicine.

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