SCIENCE心脏祖细胞文章

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Cardiogenesis and the Complex/ f. |. M2 r) G/ F: Q: w
Biology of Regenerative
) ?3 [+ \. A& A0 K2 R8 ^$ HCardiovascular Medicine  X2 i5 X2 ~! K' Q$ H4 {5 |6 D
Kenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3
/ C/ Z/ [- F- O4 z1 p7 G! VThe heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle
/ r& {, u5 q& Xcells. Understanding the pathways that drive the formation, migration, and assembly of these cells: g# U* E9 O/ a1 ?% N
into the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is! l5 e4 ~* P8 Z; |
a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo
& U+ |) C5 Z/ ^6 _  S# Ecardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These
8 [5 C& O2 o5 A: i; Pprogenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and: Q- x6 `3 ]4 i7 v
ultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering
0 {7 U! X" n6 Ptechnologies with patient-specific cardiac progenitor biology holds great promise for the
0 H5 V6 F  T& {. V, W; P% [' {development of human cell models of human disease and may lay the foundation for
; D0 Y# M3 T; R1 C# ]3 Nnovel approaches in regenerative cardiovascular medicine.

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