Nature：tbx18心外膜祖细胞能发育为心肌细胞

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标题：A myocardial lineage derives from Tbx18 epicardial& A) E2 l& a' A+ y
cells. S% a8 Q9 d& x% O+ a
出处：NATURE| Vol 454 | 3 July 2008, m( r7 P% l: h* D
作者：Chen-Leng Cai，Jody C. Martin，Yunfu Sun 1
0 w. l" P2 P/ \  e( z文摘：Understanding the origins and roles of cardiac progenitor cells is$ {, B  i6 Z/ z
important  for  elucidating  the  pathogenesis  of  congenital  and
' m4 v9 o* R- I8 ]: O0 h9 nacquired  heart  diseases 1,2 .  Moreover,  manipulation  of  cardiac$ r6 b8 ]  D) o5 c
myocyte progenitors has potential for cell-based repair strategies8 S/ W) ^( z$ x; n2 t' B
for various myocardial disorders 3 . Here we report the identifica-
+ ^  T& `9 U: s, ?1 Rtion in mouse of a previously unknown cardiac myocyte lineage
8 G* {9 Z" X+ J; O# E$ hthat derives from the proepicardial organ. These progenitor cells,
' F- l6 y$ j: V6 D3 K- zwhich express the T-box transcription factor Tbx18, migrate onto& m0 ], ]! j( w9 q
the outer cardiac surface to form the epicardium, and then make a
9 z1 \) z/ f8 H$ q% `substantial contribution to myocytes in the ventricular septum
. ~! C5 m2 N. j+ ~$ ?2 Z2 ^/ gand the atrial and ventricular walls. Tbx18-expressing cardiac pro-
2 b1 I( g$ W/ l! ]% mgenitors also give rise to cardiac fibroblasts and coronary smooth
( y+ i* \2 y4 rmuscle cells. The pluripotency of Tbx18 proepicardial cells pro-  d# ]1 w$ _: G8 T7 a
vides a theoretical framework for applying these progenitors to& h+ K7 e$ n' N& R
effect cardiac repair and regeneration.