Nature：发现形成造血干细胞小生境的细胞身份（附原文）

细胞海洋

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: J0 e# U7 |9 b* y# O% W% h5 @在骨髓中形成造血干细胞小生境的细胞身份一直不清楚。现在，Paul Frenette及其同事识别出，表达nestin的间叶干细胞为形成小生境的细胞。这些细胞与造血干细胞有密切物理关系，表达高水平的参与干细胞维护的基因，它们的删除会降低造血先祖细胞的骨髓寻的(homing)功能。
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这项工作显示，骨髓中的干细胞小生境是两种截然不同的体干细胞(somatic stem-cell)类型之间的一种伙伴关系5 A, c" W6 C, N/ _* _
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3楼原文 感谢lixiaodong 提供

细胞海洋

Nature doi:10.1038/nature09262 $ G, n. {( P+ U# a0 z) y
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Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
( w8 \, B1 z% L5 P/ r" nSimón Méndez-Ferrer,Tatyana V. Michurina,Francesca Ferraro,Amin R. Mazloom,Ben D. MacArthur,Sergio A. Lira,David T. Scadden,Avi Ma’ayan,Grigori N. Enikolopov& Paul S. Frenette
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The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells. Here we demonstrate that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component. Nestin+ MSCs contain all the bone-marrow colony-forming-unit fibroblastic activity and can be propagated as non-adherent ‘mesenspheres’ that can self-renew and expand in serial transplantations. Nestin+ MSCs are spatially associated with HSCs and adrenergic nerve fibres, and highly express HSC maintenance genes. These genes, and others triggering osteoblastic differentiation, are selectively downregulated during enforced HSC mobilization or β3 adrenoreceptor activation. Whereas parathormone administration doubles the number of bone marrow nestin+ cells and favours their osteoblastic differentiation, in vivo nestin+ cell depletion rapidly reduces HSC content in the bone marrow. Purified HSCs home near nestin+ MSCs in the bone marrow of lethally irradiated mice, whereas in vivo nestin+ cell depletion significantly reduces bone marrow homing of haematopoietic progenitors. These results uncover an unprecedented partnership between two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs.

lixiaodong

Thanks. Should read about it.

2005150122

很好的文章，谢谢分享！

冰罗布

谢谢分享，学习了

w2503

homing或许可以翻译成“归巢”

xiyanglangke

非常好的文章，谢谢分享！

exin11

xiexie

w2503

There is a new word 'mesenspheres' in this article, which refers to 'mesenchymal spheres'.

LiuRoc

谢谢！