Circ. Res：Wt1和维甲酸信号通路参与心脏心包及窦状角的的发育

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心脏心包及窦状角的的发育有赖于来自间充质的心外膜的扩增，而Wt1和维甲酸信号通路参与了这个过程, Z& B& e7 g4 |6 @* x& f8 I
Wt1 and Retinoic Acid Signaling in the Subcoelomic Mesenchyme Control the Development of the Pleuropericardial Membranes and the Sinus Horns
! G" ~, [& J5 h, {0 ]' q4 o          Pericardium and sinus horn formation are coupled and depend on the expansion and correct temporal
, q1 |; l) V) A0 d# |  U8 D' grelease of pleuropericardial membranes from the underlying subcoelomic mesenchyme. Wt1 and downstream
) ^/ x, w6 J' h6 u% w/ F5 C2 c% pRaldh2/retinoic acid signaling are crucial regulators of this process. Thus, our results provide novel insight into
" i" N5 E' v% lthe genetic and cellular pathways regulating the posterior extension of the mammalian heart and the formation
3 f1 N; O2 N' p9 q$ V, H! c5 a1 s" _" ~of its coelomic lining

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