干细胞治疗肝病综述

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Stem Cell-Based Therapies for Liver Diseases:State of theArt andNewPerspectives
& a% Y0 o8 u# QMillions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT).
& W: s* Y! L9 i- W! ~! _8 lGiven the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has: s; `; F( ~1 f: j: M+ G
been attempted to cure metabolic liver disorders and end-stage liver diseases. The evaluation of its efficacy is complicated by the
$ h1 m, _* o; n% |shortage of human hepatocytes and their difficult expansion and cryopreservation. Recent advances in cell biology have led to the
# B9 |- f" |0 m% p6 d' uconcept of “regenerative medicine”, based on the therapeutic potential of stem cells (SCs). Different types of SCs are theoretically6 {, L( t$ f$ U$ O! O/ x
eligible for liver cell replacement. These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver. @, m! B# f& f* N" I3 l% q
SCs, and extrahepatic adult SCs. Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation4 Y4 K$ [: P6 |
and the results of the clinical trials that have been published until now.
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