荷兰研究：腹部脂肪干细胞对治疗心脏病有益

qingshui1985

中新网11月18日电 据台湾“中广新闻网”18日报道，荷兰研究发现，腰部脂肪干细胞对治疗心脏病有帮助。$ \& \2 ]$ c: c8 s5 e  M, g) Q& c
    荷兰埃拉斯莫斯大学的杜克斯博士说，他把病人腹部脂肪的干细胞注射进他们的心脏以后，减少了心脏的损伤、同时也增加了血流。
' R3 t; L( x1 v5 O5 E: Y    他说，干细胞注射进心脏以后经过6个月，病人心脏接受带氧血液的能力会提高，心脏左心室送出的血液也会增加。

qingshui1985

9 ]$ f. l4 F! x5 l4 T5 ?In a novel study researchers show that stem cells taken from the fat of waistline could be used to treat heart attacks. Researchers injected stem cells obtained from waistline fat tissue into the heart of coronary patients. These cells decreased levels of damage, improved the flow of blood and pumping ability of organs.
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3 O  k; t( e# ~8 dA cosmetic procedure known as liposuction commonly used to reduce waistline of the people. This method was used to confiscate more than two hundred centimeters of fat from the bellies of the patients. The researchers secluded and taken out twenty millions adults stem cells from each sample. These regenerative cells have potential to become more than one kind of tissue.9 k& p% p2 g# M& _6 p
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The whole process took ten minutes to infuse stem cells into the heart of patients. After six months participants treated with the procedure showed more than three percent improvement in heart perfusion, it is the ability of heart to receive oxygenated blood./ Q7 a/ K3 O+ M& r* R* @& ]5 ^
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They also experienced more than five percent increased amount of blood pumped out by left ventricle of the heart chamber in comparison to the participants who took placebo infusion. The amount of damaged heart muscle in treated patients was halved by fifteen percent from thirty-one percent. But it was remained same in non treated group., s& K9 i- M1 U

% r, D- i. w: ~+ N" EThe study also found that the stem cells did not interfere with blood flow and were not associated with any potentially dangerous changes in rhythm of the heart. The study recommends that these cells can be safely acquired and infused inside the hearts of patients following an acute heart attack, explained study author Dr Eric Duckers, from Erasmus University Medical Centre in Rotterdam, the Netherlands.

qingshui1985

Study Shows Fat Stem Cells May Improve Heart Function After Heart Attack
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: ~$ C/ \& z% R5 O4 zBy Charlene Laino
- m; x% \1 {  {* rWebMD Health News
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. L; M) Q9 b+ G; W5 iReviewed by Laura J. Martin, MD
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: t4 B1 J4 o" v0 _Nov. 16, 2010 (Chicago) -- Stem cells taken from belly fat may be able to boost cardiac function after a heart attack, preliminary research suggests.% l! ^, I$ x( S, o! j: L% ?0 C
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In a study of 14 people who had a heart attack, fat-derived stem cells reduced the amount of damaged heart tissue, increased blood flow in the heart, and improved the heart's pumping ability, compared with placebo.; K! e6 ~6 N+ K/ s* P1 ?
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Due to the study's small size, however, the difference between the two groups could have been due to chance.
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"But given the dramatic and consistent results, we think it is a real effect," says study head Eric Duckers, MD, PhD, of Erasmus University Medical Center in Rotterdam, Netherlands.
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# J/ m, m9 e. e6 \. D( ~; wU.S. stem cell researcher Douglas Losordo, MD, of the program in cardiovascular regenerative medicine at Northwestern Memorial Hospital in Chicago, tells WebMD, "The evidence strongly suggests fat stem cells can stimulate the repair process after a heart attack. But these are still early days. We have to await the results of larger randomized trials [pitting placebo against fat stem cells] to determine if the method improves quality of life and extends lives."
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It's not the first time heart attack patients have been treated with stem cells. But previous studies used bone marrow stem cells, Duckers says. "The advantage of fat-derived cells is the ease with which you can get them."4 ]1 K$ B& z6 E4 V
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"You don't get enough stem cells from bone marrow, so you have to culture them in the lab, a process that can take six to eight weeks," Duckers tells WebMD. He estimates that the 40 cubic centimeters of bone marrow typically removed yields about 25,000 stem cells.9 {: d! g- }. N
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In contrast, just 100 cubic centimeters of fat tissue -- about a half a coffee cup -- contains 2 million stem cells, he says. "With that many cells, you can isolate them and go straightway back to the patient."
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  L/ A+ d1 k/ u/ M/ @& iHow the Stem Cell Technique Works
6 }. Q3 h# P0 gIn the study, the first of its kind, people were treated within 24 hours of their heart attack after undergoing cardiac catheterization to assess blood flow and angioplasty to open up the blocked heart artery and restore blood flow.& _* U$ d/ m2 z5 n" U& w
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The findings were presented here at the American Heart Association's Scientific Sessions 2010.$ N7 q4 A4 z) k7 a0 v

) l4 B0 \, ^; X. g9 C0 O8 H! sThe researchers liposuctioned fat from the abdomen of 10 patients, isolated 20 million stem cells, and infused them back into the patient through a catheter -- all in 10 minutes. The other four patients got placebo infusions.
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By six months later, SPECT imaging showed that blood flow to the heart had improved 3.5-fold in people getting fat stem cells, compared with those getting placebo. Heart pumping ability increased 5.7% in the stem cell group.# ]. C2 i/ F7 i# x* |

$ h$ f5 M) N2 \* K" A! pAs seen on MRI scans, the average area of heart muscle scarring was cut in half in the treatment group, from 31.6% after the heart attack to 15.4%.% d+ R2 O- p1 p2 v

! k7 g0 v4 ?& N, Q0 V"It was dramatic," Duckers says. "There was one patient in whom we couldn't even see a scar anymore."3 T/ Z: j# c; a

. D+ J/ Q* F: r1 g1 y( Q1 O8 ~8 P' aAmong people getting placebo infusions, there was no change in scarring.% h0 p3 i+ F+ ^0 C0 j: R, c

- o( ~; \# f9 ^+ ?! W; ?The infused stem cells did not interfere with blood flow in the heart or cause potentially fatal erratic heartbeats called ventricular arrhythmias, both of which had been a concern.9 P* J0 d% g3 @2 H

/ g4 f4 j# K, R# F( _' DTwo patients developed hematomas, an area of swelling filled with blood, after the liposuction procedure.
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& D& \8 |* Z4 U5 g8 l& uDuckers notes that all the patients were white Europeans. The results are not necessarily applicable to non-whites, he says.8 m$ }& {8 [" N; K, M

/ O3 f2 n; S. ^7 T1 [  W; QThe researchers have initiated a more robust phase II-III clinical trial called ADVANCE that will enroll up to 375 heart attack patients at 35 medical centers in the European Union. Patients will get one of two doses of fat-derived stem cells or placebo infusions.
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The study was funded by Cytori Therapeutics Inc.
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This study was presented at a medical conference. The findings should be considered preliminary as they have not yet undergone the "peer review" process, in which outside experts scrutinize the data prior to publication in a medical journal.
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SOURCES:American Heart Association's Scientific Sessions 2010, Chicago, Nov. 13-17, 2010.Eric Duckers, MD, PhD, head, molecular cardiology lab, Erasmus University Medical Center, Rotterdam, Netherlands.Douglas Losordo, MD, program in cardiovascular regenerative medicine, Northwestern Memorial Hospital, Chicago.
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8 {/ o  X6 i" J- q" G; P8 j6 R) k©2010 WebMD, LLC. All Rights Reserved.

qingshui1985

作者Eric Duckers首次报道了用腹部脂肪干细胞用于治疗心脏病。这新闻对于肥胖的心脏病患者，是条很振奋的消息。
  ~# j# F+ H+ e8 w7 X9 \但我查了很久，貌似只检索到新闻报道，! h2 x7 f7 x% k3 r6 i: |) n
没有查到发表的全文。

yonglongh

呵呵，这也了解到了了些新东西，多谢分享！

qingshui1985

回复 5# yonglongh
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呵呵，一起进步