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本帖最后由 sunsong7 于 2010-12-12 11:12 编辑 ( V% [7 H5 g* O! ]5 A$ j# m
9 ^2 s: u, U& s( \5 `7 EAntigen Processing and Presentation Wallchart
6 O' o- I/ s9 e, b \Pamela Wearsch and Peter Cresswell
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% [: D! Q) f6 O& ^! F; d- h# FThe process by which antigen-presenting cells digest proteins from inside or outside the cell and display the resulting antigenic peptide fragments on cell surface MHC molecules for recognition by T cells is central to the body's ability to detect signs of infection or abnormal cell growth. As such, understanding the processes and mechanisms of antigen processing and presentation provides us with crucial insights necessary for the design of vaccines and therapeutic strategies to bolster T-cell responses.This poster provides an updated overview of the intracellular pathways and mechanisms by which antigens are captured, processed and loaded onto MHC class I, class II and CD1d molecules for presentation to T cells.
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Assays for Human Mammary Stem and Progenitor Cells8 L2 W% ], J. Y
8 M' P8 i* q: p9 _4 HThis new wallchart provides information on the hierarchy of mammary epithelial cell differentiation and some of the functional assays that can be used to study mammary stem and progenitor cells.) \0 k! p# A2 d9 q! S b3 A1 ?
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3 X, v; w! o$ w% H" f0 C9 o |! M0 ZCell Type Frequency Wallchart
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3 Y6 j1 C% M9 F* R0 d c% xThis wallchart provides frequencies of cell types in human peripheral blood and protocols for processing blood.
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Cord Blood Wallchart" `6 g* Q ?5 \5 b, _6 ?
# \3 T; S2 v- IThis wallchart is a colorful guide to hematopoietic colonies derived from human cord blood progenitors.
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: `+ W" |! {5 G7 A4 V: M7 K; rMouse Hematopoietic Progenitors Wallchart
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This new wallchart features photographs of a variety of representative colonies derived from mouse hematopoietic progenitors, comprehensive descriptions to assist in colony identification and plating concentration guidelines for quick reference.
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5 p% H. U( r5 H aNatural Killer Cells Wallchart& N$ J5 E4 _7 C& d
; |$ U3 R3 `/ @( }, t' aEric Vivier and Sophie Ugolini, F* X+ p( H0 O0 s- y1 r
Natural killer (NK) cells were identified in 1975 as lymphocytes of the innate immune system that can kill tumour cells. Since then, NK cells have been shown to kill an array of ‘stressed’ cells and secrete cytokines that participate in shaping adaptive immune responses. A key feature of NK cells resides in their capacity to distinguish stressed cells (such as tumour cells, infected cells and damaged cells) from normal cells. Q4 F6 g7 U( T+ M; T! I
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Neural Stem Cells Wallchart' T7 L6 b1 r/ {
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Virginia Mattis, Soshana Svendsen, Dhruv Sareen and Clive Svendsen
* V1 j5 V1 a3 o: e; P8 `6 TNeural stem cells are capable of self-renewal and can generate neurons, astrocytes and oligodendrocytes. During nervous system development, NSCs within the primitive neural ectoderm give rise to neural progenitors, which rapidly become regionally and temporally specified, first generating large projection neurons and later small interneurons and glia.# U/ K) F7 S. @; ]' k x
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Pluripotent Stem Cell Biology Wallchart6 t4 {- d6 @1 b+ x: d
+ ^; X, {, W3 kChristopher Lengner and Rudolf Jaenisch
. n. P$ N( q( |7 IPluripotent cells offer great promise to the future of regenerative medicine and tissue engineering. Nuclear transfer, direct reprogramming and cell fusion can be used to experimentally induce pluripotency in somatic cells. To date, no naturally occurring pluripotent cell has been identified in the mammalian soma, and cells with pluripotent potential in the early embryo or germ lineage are difficult to isolate from patients. This makes methods of experimentally induced pluripotency in readily available somatic cells (such as skin biopsies) invaluable for the generation of patient-specific stem cells.
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Regulatory T cells Wallchart % q3 ^6 t: E6 V
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Ethan Shevach and Todd Davidson
: y* b8 k2 G- Z$ `& m% B# IRegulatory T cells are vital for keeping the immune system in check, helping to avoid immune-mediated pathology and unrestricted expansion of effector T cell populations. Accordingly, regulatory T cells have been the focus of extensive research over the past few years, and this has revealed diverse roles for those cells in numerous diseases, including autoimmunity, allergy, microbial infection and cancer. We now have a good understanding of how they arise, how they are maintained, how they exert their suppressive effects and how they might be harnessed for therapeutic intervention. This poster provides an updated overview of the development, phenotype and functions of regulatory T cells, in particular those subsets that express the transcription factor forkhead box P3 (FOXP3). The poster is freely available thanks to support from STEMCELL Technologies.
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发表于 2010-12-12 11:02
发表于 2010-12-12 13:45
