How is pluripotency determined and maintained?

argonaute

虽然是07年的review，但是我觉得还是很不错的文章。( d$ g/ `3 Y3 l, r
Mouse embryonic stem (ES) cells are pluripotent, as they have* _0 \0 I- W1 Q
the ability to differentiate into the various cell types of a
# F% H* T8 z9 _vertebrate embryo. Pluripotency is a property of the inner cell% o$ z! i, o! Q/ M4 d% J* t) \
mass (ICM), from which mouse ES cells are derived, and of the
0 e) F" ~9 o7 o( _epiblast of the blastocyst. Recent extensive molecular studies of# B' z! [/ ?7 i5 {
mouse ES cells have revealed the unique molecular mechanisms4 E; L) q, B& B2 S: D1 i, v- ~: m
that govern pluripotency. These studies show that ES cells
* p- k" @% x4 {& m" fcontinue to self-renew because of a self-organizing network of
' c( [7 o5 N1 Q$ S/ a( htranscription factors that prevents their differentiation and# ]  g+ E1 w5 G- u1 T. U
promotes their proliferation, and because of epigenetic
9 p! g8 \+ w. z! Yprocesses that might be under the control of the pluripotent! P( b: L3 K* }! D7 O
transcription factor network.

carolshen

多谢楼主哈
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