Stem cells found to home toward the injured liver

bobo

日期: 2003-07-16 今日/总浏览: 1/578
  t$ R/ v" {; E  L8 m" c! D2 s  Q; ?% w( J" D4 u! g
; O  Y9 h& V6 k- H$ C, r: ~! `

8 M( |" }9 R6 b4 u# U+ S, x0 k+ O* g
Thenowrecognizedplasticityofstemcellschallengesresearcherstofurtherdefinethemechanismsresponsiblefortheirrecruitmentanddifferentiation,sothattheymayultimatelybecomeclinicallyusefulintherepairofinjuredorgans.
4 h9 ^$ T; b" q1 c5 nIntheJuly15issueofTheJournalofClinicalInvestigation,acollaborativeresearchteamledbyTsveeLapidotandcolleaguesattheWeizmannInstituteofScienceinIsrael,andalsoincludingresearchersfromtheAlbertEinsteinCollegeofMedicineandMountSinaiMedicalCenterinNewYork,InstitutPasteurinParis,andtheChaimShebaMedicalCenter,Israel,havereportedastudythatgreatlycontributestoourunderstandingofhowhematopoieticstemcells(HSCs)hometoinjuredlivertissueandcontributetotissuerepair.TheauthorsrevealthatmigrationofHSCstotheliverisaselective,non-randomevent,requiringtheexpressionofthesignalingchemokineSDF-1andthereceptorCXCR4.ThepathwaysthatfacilitatecrosstalkbetweenHSCsandinjuredlivertissuemayserveastargetsforfuturetherapeuticprotocolsinthefieldofliverregenerationandtransplantation.8 T' q& S2 ?7 C9 g
( I! \3 q8 |  v' u5 I

3 [( h; a$ Q) z, [! `###' x/ [" l* I8 x6 S2 l
TITLE:HGF,SDF-1,andMMP-9areinvolvedinstress-inducedhumanCD34 stemcellrecruitmenttotheliver( }. ]- p: }- H& D4 m

1 ~! a- m( n, \- z$ _( J7 SAUTHORCONTACT:  M' _' H8 I" l8 g
TsveeLapidot/ }7 S5 y! D, r: t& b: Q
TheWeizmannInstituteofScience,Rehovot,Israel.' |- c! v  W/ \# U: L1 ~0 \
Phone:972-8-934-2481
; [/ E6 T) H2 y! qFax:972-8-934-4141  e7 g! [, ]* c9 C& G7 {( h
Email:Tsvee.Lapidot@weizmann.ac.il/ }) v+ M. o( i+ G" i: M  S1 ~
0 `7 x: c6 Y2 L* _! y) G
ViewthePDFofthisarticleat:https://www.the-jci.org/press/17902.pdf
! i8 \% W# h8 ^9 Z$ i. e+ G( _% {
, r6 H+ d# h* T  a" i2 F1 A0 c6 M$ k! K
$ c9 ?3 P7 s6 B! O4 e6 C9 k! P1 F

7 j/ U6 Y& g4 s
* G7 U4 R& O8 [作者:
/ I2 k4 T% w+ ]; C. u来源: Journal of Clinical Investigation1 ?3 v& |) O8 `2 |9 g6 c
发布者: 亦云