Nature出版集团Nature Biotechnology 15周年纪念文章

a2782953

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& e* t8 ^8 ?1 A1 R# R为了纪念 Nature Biotechnology 15周年，下面这篇文章介绍了过去5年里被引用最多的文章作者对他们自己工作的评论，并有他们对自己所关注的领域的某些意见。6 `. g' d4 S/ d1 f& p3 }

tpwang

回复 a2782953 的帖子% E9 N; V5 `/ i' l
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"Shinya Yamanaka says the Myc genes may hold the key to other aspects of reprogramming.") j( G$ k  q4 }
"Myc family genes can promote reprogramming independent of their ability to make tumors."3 e# V8 k" h7 M9 g* z. B( O; I
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"...Yamanaka warns, merely eliminating Myc or integrating factors does not guarantee the
! V: _0 T4 q) I6 F* j: ~$ ]$ ?. xsafety of iPS cells."6 A- }4 k5 P0 Z, ?3 `
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"Some iPS cell–derived tumors could be caused by reactivating the gene encoding Myc, others by residual undifferentiated cells that resist cues for differentiation, a property that correlates with the tissue from which the iPS cells were originally derived3. And, according to Yamanaka, there may be other causes..."3 u" ]5 D9 l6 L) C+ l( V
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总体来说，即便去掉外源性Myc，iPS的成瘤风险仍然无法排除。听起来还是比较不那么乐观。

ambassador

好！Kun Zhang says that  using padlock probes to detect methylation was really a bet.
, f3 k* N1 X: E7 E& o8 \$ E这个锁式探针是什么东东？请做表观遗传的牛人解释下、
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lifescience1

谢谢

farmer

标记。