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作者：Ehrlich Maximow1 5 M7 B7 q K8 z6 y
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2 z s- t4 |# {" d+ L 【关键词】 Stromal
- {+ T2 V n7 c. f& A; ~% r, X Correspondence regarding this Primer should be sent to Marshall A. Lichtman, M.D., 601 Elmwood Avenue, Box 610, Rochester, NY 14642 or mal@urmc.rochester.edu7 T0 w, U p: A0 {
Stromal cells elaborate./ d) `- F& s6 W9 z# F
Cytokines orchestrate.
9 ^) M8 `7 X& { ISignal transducers propagate.
" K. |! h4 ?/ c3 jGenes dictate.3 Q+ n3 k7 q- i4 b' `" }$ {
Transcription factors mediate. mRNAs translate.5 H% B S R4 \* v7 V" H
Proteins effectuate
; x6 O f( E* b: oStem cells differentiate.5 n1 f# `% o# \! s, ~/ \5 r7 O' U" f
(It appears that they can also transmutate!)
7 h5 j2 @6 I9 N$ l1 yProgenitor cells proliferate( V% p3 W: a! M0 G4 k
Erythroblasts hemoglobinate+ a+ r h' @% A
Myelocytes granulate.- y$ g# a+ k0 N5 ^. E- `
Megakaryocytes fragmentate.
3 k! N# |) s- b! F- o% cMature cells circulate." T' Q8 J1 E" q; r+ ]3 @
Blood cell counts fluctuate.
' w3 j$ W# w# x$ l0 v% O( }Red cells oxygenate.6 ]0 f! Y. a2 f \+ W; d0 X
Neutrophils emigrate.# p4 h) u: S9 { }$ E; Q- l
Basophils and eosinophils degranulate.8 E& ]& }! K; d% f8 G! ^
Monocytes transfigurate.+ f$ P. x/ ^3 s) i" w* B2 a
Dendritic cells cooperate.
! ^# l! E5 R. L4 KLymphocytes activate.8 i0 f) [( n) ^ x
End cells disintegrate.1 I3 B' U. S. N7 c: I$ U& w
Hematopoietic scientists cogitate,
* V8 q1 V2 N8 A0 j+ t9 n( eThen, they may elutriate.! \; T. f. S8 x( X
Hematologists medicate,( Q5 y* F* J3 [" x
And occasionally they irradiate.
2 ?& n* b- L, a( w9 |0 `' |Followed sometimes by a stem cell infusate.4 l0 y# o. |1 H0 v0 H
They also may prognosticate,) R4 `3 ], Z6 n' j F0 w8 A5 U7 C% r
But they often over- or under-estimate.
" Y% u6 N2 l |# i% l3 k' |Now we have embryonal stem cells on our plate.
P( A7 n) m( g, g0 k9 A, }- STheir use is undergoing ethical debate.
$ K8 o7 a3 k' H; ]; U- Q/ tThe point is that if one can direct their fate,
6 E9 B' Z$ c R: }Certain diseases we could abrogate.# F: j9 e! l# G5 K+ J% r6 i
FOOTNOTES
* R( V8 s0 O; S8 i2 r1 It was initially thought that the author is a distant relative of Paul Ehrlich, the German chemist, immunologist, and Nobel Prize laureate whose research with aniline dyes lead to the polychrome stains for blood and marrow cells and of Alexander A. Maximow, the eminent Russian embryologist and histologist, who provided the first evidence for an hematopoietic stem cell as the source of blood cells. The latter disclosure was made in a lecture delivered to the Hematologic Society of Berlin in 1909. Careful editorial inquiry uncovered that Ehrlich Maximow is the pseudonym of Marshall A. Lichtman, M.D., Professor of Medicine and Biochemistry and Biophysics at the University of Rochester Medical Center. |
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发表于 2009-3-5 00:21
发表于 2015-6-3 08:34
