Concise Review: Stem Cells, Myocardial Regeneration, and Methodological Artifact - 《stemcells》干细胞学杂志干细胞之家



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发表于 2009-3-5 00:57 |只看该作者 |倒序浏览 |打印

作者：Piero Anversaa, Annarosa Leria, Marcello Rotaa, Toru Hosodaa, Claudia Bearzia, Konrad Urbaneka, Jan Kajsturaa, Roberto Bollib作者单位：aCardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York, USA;bInstitute of Molecular Cardiology, University of Louisville, Louisville, Kentucky, USA



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      【摘要】
   This review discusses the current controversy about the role that endogenous and exogenous progenitor cells have in cardiac homeostasis and myocardial regeneration following injury. Although great enthusiasm was created by the possibility of reconstituting the damaged heart, the opponents of this new concept of cardiac biology have interpreted most of the findings supporting this possibility as the product of technical artifacts. This article challenges this established, static view of cardiac growth and favors the notion that the mammalian heart has the inherent ability to replace its cardiomyocytes through the activation of a pool of resident primitive cells or the administration of hematopoietic stem cells. . ?2 n) M! C1 U% X/ `  F* o! Y
      【关键词】 Heart Confocal and light microscopy Mitosis Chimerism Bone marrow cell transdifferentiationEnhanced green fluorescent protein autofluorescence
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