- 积分
- 0
- 威望
- 0
- 包包
- 483
|
Correspondence regarding this Primer should be sent to Marshall A. Lichtman, M.D., 601 Elmwood Avenue, Box 610, Rochester, NY 14642 or mal@urmc.rochester.edu; x+ _4 k3 Y. o# g
3 \% L. K3 t8 {' X/ b
Stromal cells elaborate.
8 |0 E0 X8 C* U# X, k
Y' D! ^' R" S- l3 aCytokines orchestrate.
0 F5 a* f6 ?% B3 F! f% D. [8 q, N6 R2 d4 s- w
Signal transducers propagate.
+ P$ W' m, k4 s( D6 M; ?; k9 J5 d9 K9 s! X$ c7 a( l
Genes dictate.
8 A7 I* C( o$ n) `) G; g8 k1 O* R3 w* \$ a4 i/ M( q
Transcription factors mediate. mRNAs translate.
& B' e1 ]4 E6 r+ b" F7 Q& Z7 k3 U5 r& g( v4 O" i
Proteins effectuate
1 f( ?' q( F$ |5 m" u
: m' k; Y% {! u- }! G0 v2 S! NStem cells differentiate." k E; @: t+ b" C* ]5 P
( b/ b- ~' t5 S! W. a# ^
(It appears that they can also transmutate!)$ |! @! h2 q2 V. m+ }
& f6 ?3 L R- ^Progenitor cells proliferate
2 b7 h' h; L! B; Q0 e7 F0 Y Q# `5 U8 z1 b+ D% U
Erythroblasts hemoglobinate9 r4 e2 R% z5 N& v9 |, L: w
, r$ a. ^1 d* R# G, G
Myelocytes granulate.% z3 m0 p' M o
( E3 N5 e. U; v7 ]Megakaryocytes fragmentate.. c: e% H' }- j
?0 b# E7 k: d' GMature cells circulate.
- @/ o) u0 M+ T y- v6 Z; H( e, x+ Y% G; U& X1 O
Blood cell counts fluctuate.
, s9 v7 k* J0 G3 g& D' |" G3 h2 r) j9 e9 h; B3 e P ~% g
Red cells oxygenate.
1 o. Y! X- ~" Z6 V
# @' A L( c& P7 h h5 _! I1 [Neutrophils emigrate.' u I' _' b- F; G
6 q2 M) I! s8 B& h. c# GBasophils and eosinophils degranulate.* x8 Z* S* e- D$ I0 q7 [
" R/ h9 ?5 b" q
Monocytes transfigurate.: {, a. \8 ~/ q6 d5 N
. E1 t7 F8 n# j) E+ e5 VDendritic cells cooperate.5 K. p7 T; [, \; C6 W
9 n* m* b- Q, S; G' r4 K% gLymphocytes activate.5 v4 }+ Z' S8 M' d. _7 z, ?
/ {# E: s1 a" s& q5 W! V- _. aEnd cells disintegrate., }! q2 D8 {$ p, J3 F8 A
$ q. l% l3 i- |$ CHematopoietic scientists cogitate,
' j+ e$ U. O `! T
9 |% E. q2 L* [& T8 l3 QThen, they may elutriate.& ]% Q7 a: R. L& \4 W
1 z" n- ^% F% l+ R6 H( j3 V4 iHematologists medicate,
$ d3 I1 x8 R5 q. E8 N W8 v5 S$ f, D' z* ^8 n3 o( x8 I: I1 b
And occasionally they irradiate.3 r* l% F) m8 i8 J8 \2 `! Y
# o5 n: y! W ]! A1 I2 J
Followed sometimes by a stem cell infusate.3 _* a" p* A3 B+ w* O
4 g# ^' ~* W6 Y( j
They also may prognosticate,
* q, h& g8 C) U" j: k4 e+ j. C# ?& j' K% C* Q" I, B# h9 I
But they often over- or under-estimate.5 O% I0 A+ y4 x/ ?0 O4 M
% P1 Y8 U% y) {/ |; W" d; }2 H
Now we have embryonal stem cells on our plate.
0 W6 r% z) v; ~& {0 ~1 o# u$ Y; r$ u$ A) y) s7 E3 y, y9 T( O) F
Their use is undergoing ethical debate.
6 C1 }& D6 j9 ~. L4 V3 k9 `5 ]5 |$ }" ~% _
The point is that if one can direct their fate,- F- I: f% I/ p/ y% E4 L: }8 }
. F" G8 q, `1 `+ ?0 `4 oCertain diseases we could abrogate.
0 H7 W& r/ M" I8 @2 X' k% c8 V" R7 c! i( j! T
FOOTNOTES8 J4 r* c7 H* ]
" }0 ^, U2 S: `. l( |4 e$ p% t' p
1 It was initially thought that the author is a distant relative of Paul Ehrlich, the German chemist, immunologist, and Nobel Prize laureate whose research with aniline dyes lead to the polychrome stains for blood and marrow cells and of Alexander A. Maximow, the eminent Russian embryologist and histologist, who provided the first evidence for an hematopoietic stem cell as the source of blood cells. The latter disclosure was made in a lecture delivered to the Hematologic Society of Berlin in 1909. Careful editorial inquiry uncovered that Ehrlich Maximow is the pseudonym of Marshall A. Lichtman, M.D., Professor of Medicine and Biochemistry and Biophysics at the University of Rochester Medical Center.(Ehrlich Maximow1) |
|