造血干细胞会传染白血病吗？

FreeCell

正常细胞移植到宿主体内后，由于免疫反应而被排斥，多不易存活。但是肿瘤细胞具有可移植性，人的肿瘤细胞可移植到鼠类体内，形成移植瘤。那么，万一用上白血病人的造血干细胞会不会得白血病？

HMC

这个还有待考证

FreeCell

嘻嘻， 真的有哇！！！
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Haematologica. 2005 Jul;90(7):969-75.
3 S6 S! c9 L/ g. K2 O) VDevelopment of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT).
& v, b% i- k3 W4 zHertenstein B, Hambach L, Bacigalupo A, Schmitz N, McCann S, Slavin S, Gratwohl A, Ferrant A, Elmaagacli A, Schwertfeger R, Locasciulli A, Zander A, Bornhäuser M, Niederwieser D, Ruutu T; Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation.
" e/ @7 x1 p/ g) VSourceHannover Medical School, Department of Hematology and Oncology, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. Hertenstein.Bernd@mh-hannover.de
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Abstract6 h+ T2 T3 H" P" y0 Y/ O: k
Leukemia in donor cells (donor cell leukemia; DCL) has been reported as a rare but severe complication of allogeneic stem cell transplantation (SCT). However, the incidence, potential pathogenetic factors, therapeutic options and outcome of patients suffering from DCL and the leukemia risk of their donors are not well defined. A questionnaire survey was carried out within European Blood and Marrow Transplantation Group (EBMT) centers. Ninety-one EBMT centers participated in this survey, covering 10489 allogeneic SCT between 12/1982 and 09/2003. Fourteen cases of DCL, most with a myeloid phenotype (7 cases of acute myeloid leukemia, 3 each of acute lymphocytic leukemia and 1 case of chronic myeloid leukemia) were identified. Demonstration of donor cell origin included molecular analysis of chimerism in most cases. DCL type and cytogenetic alterations were independent from the original disease. The median time between transplantation and diagnosis of DCL was 17 months (4-164). No type of conditioning, donor, graft manipulation, graft-versus-host disease prophylaxis or subsequent complications were identified as risk factors for DCL. Chemotherapy induced remissions in DCL and 2 of 5 patients remain alive in remission after a second transplant. None of the stem cell donors developed hematologic malignancies (median follow-up period of 9 years; range 6-30 years). DCL is an extremely rare complication of allogeneic SCT in which treatment attempts with chemotherapy and a second SCT are justified. Donors are not at an increased risk of developing hematologic malignancies.
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