|
  
- 积分
- 1933
- 威望
- 1933
- 包包
- 4926
|
嘻嘻，道高一尺魔高一丈，人间正道是沧桑4 \- @& f$ d9 v: S: M
U* Q' q" W8 Q
Natural Killer Cells in Human Cancer:FromBiological Functions to Clinical Applications6 _. ^) J y) C9 X5 G: W: s
, A! B, ^! G- ^( l' o) a
Natural killer (NK) cells are central components of the innate immunity. In murine models, it has been shown that NK cells can control both local tumor growth and metastasis due to their ability to exert direct cellular cytotoxicity without prior sensitization and to secrete immunostimulatory cytokines like IFN-γ. The latter participates in cancer elimination by inhibiting cellular proliferation and angiogenesis, promoting apoptosis, and stimulating the adaptive immune system, and it is instrumental for enhancing Ag processing and presentation. Nevertheless, NK cells display impaired functionality and capability to infiltrate tumors in cancer patients. Also, NK cells are feasible targets of stimulation to participate in immunotherapeutic approaches like antibody-based strategies and adoptive cell transfer. Thus, multiple attempts currently aimto manipulate NK for utilization in the immunotherapy of cancer. |
|
发表于 2011-5-4 17:13
发表于 2011-5-4 18:51
