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澳大利亚国立大学Lineweaver教授设计了一个癌战模型,认为“最好是将癌症理解为一片10亿年原始细胞构成的荒原,当时人类只不过是由一些部分分化特征的细胞编制出的松散群落。”
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“癌并不是随意演变,新的患者体内的癌沿着其他患者体内相似的轨迹简单地在重演”$ B6 Y9 \6 Y+ @1 O. _! ?
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' n( k. H# D6 O) v; E/ h' ^7 BAstrobiologists design cancer-fighting model
, Z8 x4 s! `/ A9 o$ D% ^Tuesday, 8 February 2011Cosmos Online http://www.cosmosmagazine.com/ne ... ight-against-cancer
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" f3 y5 j# s* m2 FA new model designed by astrobiologists should give oncologists new hope in the fight against cancers.$ z" k3 C" g) q4 F( s0 f
Credit: Australian National University$ }& a0 l$ g( u. B3 i5 A) p/ x/ D8 |5 Z
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CANBERRA: In an interplanetary meeting of the minds, astrobiologists and oncologists have worked together to provide new insights into the origins of the deadly cancer disease.
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$ V# I. H% q7 I# A# }Working with the United States’ National Institutes of Health (NIH), a team of specialists from the two fields have come up with some important new understandings of what cancer is.
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The new model depicts cancer as an atavism – an evolutionary throwback, according to Charles Lineweaver from the Research School of Astronomy and Astrophysics and the Research School of Earth Sciences at Australian National University in Canberra, who worked with Paul Davies at Arizona State University.
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' e# \( n& u' I8 MCancer yet to evolve into new forms* ^* y/ s8 \2 U d8 P' C
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“Unlike bacteria and viruses, cancer has not developed the capacity to evolve into new forms,” said Lineweaver./ W7 c2 o8 s% ~( ~+ ]0 J4 _
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“In fact, cancer is better understood as the reversion of cells to the way they behaved a little over one billion years ago, when humans were nothing more than loose-knit colonies of only partially differentiated cells.”
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1 T% T3 B! a+ E" W“We think that the tumours that develop in cancer patients today take the same form as these simple cellular structures did more than a billion years ago,” he said of the research published in the journal Physical Biology.4 V9 ]' r& V% c1 h4 m" C( V; g5 `
( c8 T; k5 y" W; |9 ]. qCancer going nowhere evolutionarily
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Looking at life from the big picture point of view, outside the oncologists’ laboratories, reminds scientists that cancer does not invade the human body, but is in fact already built into our DNA.( _2 ]% o- e- R) Z$ h
: ]1 G" e C1 b$ j, ]6 {1 U5 b“Our new model should give oncologists new hope,” said Lineweaver. “It suggests that cancer is a limited and ultimately predictable adversary.
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6 [; C2 o+ Y9 _; X“Cancer is not going anywhere evolutionarily; it simply starts up in a new patient similar to the way it started in the previous one.”
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