基因改变细胞可以消除化学治疗引起的毒性作用

aoppolle

Gene-modified cells could protect against chemotherapy's toxic effects
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' {4 N3 O7 W& Q; F8 l& }The usual doses of chemotherapy drugs can cause serious toxic effects in quickly dividing tissues such as the bone marrow.
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But now, researchers at Fred Hutchinson Cancer Research Centre suggest that one possible approach to reduce this toxic effect on bone marrow cells is to modify the cells with a gene that makes them resistant to chemotherapy.; ?; u$ o3 _2 n( i7 E/ F: `
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Hans-Peter Kiem and colleagues presented data from a clinical trial in which bone marrow stem cells from patients with brain tumors were removed and modified with a retrovirus vector to introduce the chemotherapy-resistant gene. The cells were then re-infused into the patients.
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* e; S* F9 ^/ |: q. j4 PIn the trial, which was designed to evaluate safety and feasibility, patients were safely administered gene-modified blood stem cells that persisted for more than one year and did not show any apparent harmful effects., p' S9 x8 T& G( Q! J9 g; }2 H2 v

7 F% u6 m. C; }- }0 T"Our initial results are encouraging because our first patient is still alive and without evidence of disease progression almost two years after diagnosis," Kiem said.% Q, E7 M4 y" t1 `; y% I. {* X

* g1 i* j3 ~2 j9 r0 P3 Q% @& ]The results of the trial suggest the administration of the modified cells represent a safe method for protecting marrow and blood cells from the harmful effects of chemotherapy in brain tumor patients. 4 i3 d+ w& i8 F) i/ c
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The research was reported at the annual meeting of the American Society of Gene and Cell Therapy in Seattle.
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wys7416

化学毒性对细胞是种伤害，其破坏的基因是什么不清楚，但转染的基因可以修复这种损害，说明两者存在密切的关系，对于实践应用具有很大的帮助